Reactome | MAP2K2 [cytosol]

MAP2K2 [cytosol]

Stable Identifier

R-HSA-59504

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MEK2, Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2), Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2

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External Reference Information

External Reference

UniProt:P36507 MAP2K2

Gene Names

MAP2K2, MEK2, MKK2, PRKMK2

Chain

chain:1-400

Reference Genes

BioGPS Gene:5605 MAP2K2

COSMIC (genes):MAP2K2 MAP2K2

CTD Gene:5605 MAP2K2

dbSNP Gene:5605 MAP2K2

ENSEMBL:ENSG00000126934 MAP2K2

HGNC:6842 MAP2K2

KEGG Gene (Homo sapiens):5605 MAP2K2

Monarch:5605 MAP2K2

NCBI Gene:5605 MAP2K2

OMIM:601263 MAP2K2

UCSC:P36507 MAP2K2

Reference Transcript

RefSeq:NM_030662.3 MAP2K2

Other Identifiers

0003710047

1131_at

11716318_x_at

1S9I

202424_at

213490_s_at

3023305

3023308

3023309

3023310

3835

3846639

3846640

3846643

3846645

3846646

3846650

3846652

3846653

3846654

3846659

3846660

3846663

3846664

3846665

3846666

4H3Q

51993

5605

8032761

A_23_P208835

AAH00471

AAH18645

BC000471

BC018645

CAB003835

CCDS12120

ENSG00000126934

ENSP00000262948

ENST00000262948

ENST00000262948.9

EntrezGene:5605

EntrezGene:MAP2K2

g13489053_3p_at

g13489053_3p_x_at

G5E9C7

GE57609

GO:0000165

GO:0000166

GO:0000187

GO:0003674

GO:0004672

GO:0004674

GO:0004708

GO:0004712

GO:0004713

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005777

GO:0005778

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005911

GO:0005925

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007165

GO:0008150

GO:0009058

GO:0009898

GO:0010629

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0023014

GO:0030165

GO:0030234

GO:0031410

GO:0032147

GO:0032872

GO:0034641

GO:0036289

GO:0043167

GO:0043226

GO:0043497

GO:0043539

GO:0045893

GO:0046872

GO:0048471

GO:0070371

GO:0071902

GO:0090170

GO:0097110

GO:1903800

GO:2000641

HGNC:6842

HPA051993

Hs.72241.1.S1_3p_a_at

ILMN_1657968

ILMN_1752423

IPR000719

IPR008271

IPR011009

IPR017441

L11285

L11285_at

LRG_750

LRG_750t1

MAP2K2

MAP2K2-201

MIM:601263

MIM:615280

NM_030662

NP_109587

PF00069

PH_hs_0029886

SM00220

TC19001058.hg

UPI000012F489

XM_006722799

XM_017026989

XP_006722862

XP_016882478

Participant Of

input

Anthrax LF cleaves target cell MAP2K2 (MEK2)

hasComponent

Other forms of this molecule

p-S,T-MAP2K2 [cytosol]

p-S222,S226-MAP2K2 [cytosol]

MAP2K2(11-400) [cytosol]

MAP2K2(1-10) [cytosol]

Inferred To

MAP2K2 [cytosol] (Bos taurus)

MAP2K2 [cytosol] (Caenorhabditis elegans)

MAP2K2 [cytosol] (Canis familiaris)

MAP2K2 [cytosol] (Danio rerio)

MAP2K2 [cytosol] (Dictyostelium discoideum)

MAP2K2 [cytosol] (Drosophila melanogaster)

MAP2K2 [cytosol] (Mus musculus)

MAP2K2 [cytosol] (Rattus norvegicus)

MAP2K2 [cytosol] (Saccharomyces cerevisiae)

MAP2K2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_109587.1

ZINC - World Drugs

MP2K2_HUMAN

OpenTargets

ENSG00000126934

ZINC - FDA approved

MP2K2_HUMAN

ZINC - Substances

MP2K2_HUMAN

ZINC - Biogenic

MP2K2_HUMAN

ZINC target

P36507

PRO

P36507

PDB

4H3Q, 1S9I

ZINC - Investigational

MP2K2_HUMAN

IntEnz

2.7.12.2

GeneCards

P36507

Orphanet

16378

ZINC - Predictions - Purchasable

MP2K2_HUMAN

HMDB Protein

HMDBP09528

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.791	6
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) BRAF [cytosol] (R-HSA-167224) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.744	7
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [plasma membrane] (R-HSA-206222) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.667	3
UniProt:O95273 CCDB1			0.556	3
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.553	2
UniProt:Q8IVT5 KSR1	5	KSR1 [cytosol] (R-HSA-5672587) p-S311,S406 KSR1 [cytosol] (R-HSA-5672654) p-S311 KSR1 [cytosol] (R-HSA-5672652) p-S311,Y552 KSR1 [plasma membrane] (R-HSA-5672659) p-S311,Y552 KSR1 [cytosol] (R-HSA-5672656)	0.547	6
UniProt:Q12959 DLG1	4	DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [plasma membrane] (R-HSA-375977)	0.543	10
UniProt:Q61097	5	KSR1 [cytosol] (R-MMU-5672587) phospho-p-S311,S406 KSR1 [cytosol] (R-MMU-5672654) phospho-p-S311 KSR1 [cytosol] (R-MMU-5672652) phospho-p-S311,Y552 KSR1 [plasma membrane] (R-MMU-5672659) phospho-p-S311,Y552 KSR1 [cytosol] (R-MMU-5672656)	0.508	2
UniProt:P61978-2 HNRNPK			0.488	2
UniProt:Q96II5 Q96II5			0.488	2
UniProt:P00540 MOS			0.488	2