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MAP2K2 [cytosol]
Stable Identifier
R-HSA-59504
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MEK2, Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2), Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Signaling by BRAF and RAF fusions (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
Anthrax lef cleaves target cell MAP2K2 (MEK2) (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
MAP2K2 dimer [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36507 MAP2K2
Gene Names
MAP2K2, MEK2, MKK2, PRKMK2
Chain
chain:1-400
Reference Genes
BioGPS Gene:5605 MAP2K2
COSMIC (genes):MAP2K2 MAP2K2
CTD Gene:5605 MAP2K2
dbSNP Gene:5605 MAP2K2
ENSEMBL:ENSG00000126934 MAP2K2
HGNC:6842 MAP2K2
KEGG Gene (Homo sapiens):5605 MAP2K2
Monarch:5605 MAP2K2
NCBI Gene:5605 MAP2K2
OMIM:601263 MAP2K2
UCSC:P36507 MAP2K2
Reference Transcript
RefSeq:NM_030662.3 MAP2K2
Other Identifiers
0003710047
1131_at
11716318_x_at
202424_at
213490_s_at
3023305
3023308
3023309
3023310
3846639
3846640
3846643
3846645
3846646
3846650
3846652
3846653
3846654
3846659
3846660
3846663
3846664
3846665
3846666
5605
8032761
A_23_P208835
GE57609
GO:0000165
GO:0000166
GO:0000187
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005777
GO:0005778
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005911
GO:0005925
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007165
GO:0008150
GO:0009058
GO:0009898
GO:0010629
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0030165
GO:0030234
GO:0030674
GO:0031410
GO:0032872
GO:0034641
GO:0036289
GO:0043167
GO:0043226
GO:0043539
GO:0045893
GO:0046872
GO:0048471
GO:0070371
GO:0071902
GO:0090170
GO:0097110
GO:1903800
GO:2000641
Hs.72241.1.S1_3p_a_at
ILMN_1657968
ILMN_1752423
L11285_at
PH_hs_0029886
TC19001058.hg
g13489053_3p_at
g13489053_3p_x_at
Participant Of
input
Anthrax lef cleaves target cell MAP2K2 (MEK2)
hasComponent
MAP2K1:MAPK2K2 heterodimer [cytosol]
MAP2K2 dimer [cytosol]
Other forms of this molecule
MAP2K2(1-10) [cytosol]
MAP2K2(11-400) [cytosol]
MAP2K2 C125S [cytosol]
MAP2K2 P128Q [cytosol]
MAP2K2 V35M [cytosol]
p-S,T-MAP2K2 [cytosol]
p-S222,S226-MAP2K2 [cytosol]
MAP2K2 N126D [cytosol]
MAP2K2 L46F [cytosol]
MAP2K2 F57C [cytosol]
MAP2K2 Y134C [cytosol]
Inferred To
mek-2 [cytosol] (Caenorhabditis elegans)
MAP2K2 [cytosol] (Bos taurus)
MAP2K2 [cytosol] (Canis familiaris)
MAP2K2 [cytosol] (Sus scrofa)
Dsor1 [cytosol] (Drosophila melanogaster)
Map2k2 [cytosol] (Mus musculus)
Map2k2 [cytosol] (Rattus norvegicus)
map2k2a [cytosol] (Danio rerio)
Cross References
RefSeq
NP_109587.1
ZINC - World Drugs
MP2K2_HUMAN
OpenTargets
ENSG00000126934
ZINC - FDA approved
MP2K2_HUMAN
ZINC - Substances
MP2K2_HUMAN
ZINC - Biogenic
MP2K2_HUMAN
ZINC target
P36507
PRO
P36507
PDB
1S9I
,
4H3Q
ZINC - Investigational
MP2K2_HUMAN
Target Pathogen
5b354852be737e166372ed6c
HPA
ENSG00000126934-MAP2K2
GeneCards
P36507
Ensembl
ENSP00000262948
,
ENSG00000126934
,
ENST00000262948
ZINC - Predictions - Purchasable
MP2K2_HUMAN
Orphanet
16378
HMDB Protein
HMDBP09528
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.839
7
UniProt:P15056 BRAF
68
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF [cytosol]
(R-HSA-167224)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
BRAF G469R [cytosol]
(R-HSA-9648621)
BRAF L597R [cytosol]
(R-HSA-9648617)
BRAF G469E [cytosol]
(R-HSA-9648618)
BRAF L597Q [cytosol]
(R-HSA-9648619)
BRAF G466A [cytosol]
(R-HSA-9648613)
BRAF G466V [cytosol]
(R-HSA-9648838)
BRAF N581S [cytosol]
(R-HSA-9648850)
BRAF G464V [cytosol]
(R-HSA-9648611)
p-BRAF L597V [plasma membrane]
(R-HSA-8936647)
p-BRAF L505H [plasma membrane]
(R-HSA-9648862)
p-BRAF G464E [plasma membrane]
(R-HSA-8936645)
p-BRAF F595L [plasma membrane]
(R-HSA-8936641)
p-BRAF A246P [plasma membrane]
(R-HSA-9651188)
p-BRAF E586K [plasma membrane]
(R-HSA-8936639)
p-BRAF N581D [plasma membrane]
(R-HSA-9651191)
p-BRAF V600K [plasma membrane]
(R-HSA-8936651)
p-BRAF G464V [plasma membrane]
(R-HSA-9648633)
p-BRAF T244P [plasma membrane]
(R-HSA-9651194)
p-BRAF G469E [plasma membrane]
(R-HSA-9648634)
p-BRAF G466V [plasma membrane]
(R-HSA-9648859)
p-BRAF G469V [plasma membrane]
(R-HSA-9648628)
p-BRAF G466A [plasma membrane]
(R-HSA-9648629)
p-BRAF L597Q [plasma membrane]
(R-HSA-9648630)
p-BRAF L597R [plasma membrane]
(R-HSA-9648631)
p-BRAF N581S [plasma membrane]
(R-HSA-9648866)
p-BRAF G469R [plasma membrane]
(R-HSA-9648627)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
BRAF G534R [cytosol]
(R-HSA-9651134)
BRAF S467A [cytosol]
(R-HSA-9651161)
BRAF K601N [cytosol]
(R-HSA-9648857)
BRAF G469A [cytosol]
(R-HSA-6802381)
BRAF L485F [cytosol]
(R-HSA-9651147)
BRAF Q257R [cytosol]
(R-HSA-9651157)
BRAF K499E [cytosol]
(R-HSA-9651142)
BRAF V600E [cytosol]
(R-HSA-6802498)
BRAF K601E [cytosol]
(R-HSA-9648833)
BRAF V600E V169_M438del [cytosol]
(R-HSA-6802489)
BRAF V600E V47_D380del [cytosol]
(R-HSA-6802491)
BRAF V600E V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.802
9
UniProt:P04049 RAF1
54
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.745
5
UniProt:Q8IVT5 KSR1
5
p-S311,Y552 KSR1 [plasma membrane]
(R-HSA-5672659)
p-S311,Y552 KSR1 [cytosol]
(R-HSA-5672656)
p-S311 KSR1 [cytosol]
(R-HSA-5672652)
KSR1 [cytosol]
(R-HSA-5672587)
p-S311,S406 KSR1 [cytosol]
(R-HSA-5672654)
0.659
8
UniProt:Q96II5 Q96II5
0.601
4
UniProt:P61978-2 HNRNPK
0.556
3
UniProt:O95273 CCDB1
0.556
3
UniProt:P00540 MOS
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q92905 COPS5
2
COPS5 [cytosol]
(R-HSA-416963)
COPS5 [nucleoplasm]
(R-HSA-5697019)
0.553
2
UniProt:Q12959 DLG1
4
DLG1 [endoplasmic reticulum membrane]
(R-HSA-9610593)
DLG1 [cytosol]
(R-HSA-416332)
DLG1 [transport vesicle membrane]
(R-HSA-9610631)
DLG1 [plasma membrane]
(R-HSA-375977)
0.543
10
UniProt:P68366 TUBA4A
9
TUBA4A [axonemal microtubule]
(R-HSA-5610443)
TUBA4A [cytosol]
(R-HSA-191694)
TUBA4A [extracellular region]
(R-HSA-350734)
Polyglutamyl-TUBA4A [cytosol]
(R-HSA-8867386)
L-isoglutamyl polyglycyl-TUBA4A [cytosol]
(R-HSA-8867378)
TUBA4A unfolded [cytosol]
(R-HSA-392771)
TUBA4A folding intermediate [cytosol]
(R-HSA-392800)
Ac K40 TUBA4A [axonemal microtubule]
(R-HSA-5624859)
AcK-TUBA4A [cytosol]
(R-HSA-5618318)
0.527
3
UniProt:P11142 HSPA8
10
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
3
UniProt:Q61097
5
Ksr1 [cytosol]
(R-MMU-5672587)
phospho-Ksr1 [cytosol]
(R-MMU-5672654)
phospho-Ksr1 [cytosol]
(R-MMU-5672652)
phospho-Ksr1 [plasma membrane]
(R-MMU-5672659)
phospho-Ksr1 [cytosol]
(R-MMU-5672656)
0.508
2
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