Reactome | NDUFA13 [mitochondrial inner membrane]

NDUFA13 [mitochondrial inner membrane]

Stable Identifier

R-HSA-59936

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase B16.6 subunit , Complex I-B16.6, CI-B16.6, Gene associated with retinoic-interferon-induced mortality 19 protein, GRIM-19, Cell death-regulatory protein GRIM-19, CGI-39, CDA016

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA13 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P0J0 NDUFA13

Gene Names

NDUFA13, GRIM19, CDA016, CGI-39

Chain

initiator methionine:1, chain:2-144

Reference Genes

BioGPS Gene:51079 NDUFA13

COSMIC (genes):NDUFA13 NDUFA13

CTD Gene:51079 NDUFA13

dbSNP Gene:51079 NDUFA13

ENSEMBL:ENSG00000186010 NDUFA13

HGNC:17194 NDUFA13

KEGG Gene (Homo sapiens):51079 NDUFA13

Monarch:51079 NDUFA13

NCBI Gene:51079 NDUFA13

OMIM:609435 NDUFA13

UCSC:Q9P0J0 NDUFA13

Reference Transcript

RefSeq:NM_015965.6 NDUFA13

Other Identifiers

11720342_s_at

11757719_x_at

16860047

220864_s_at

3825826

3825830

3825831

3825833

3825835

3825836

3825837

45339_at

51079

8027205

A_23_P119627

GE82057

GO:0003674

GO:0003954

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005746

GO:0005747

GO:0006091

GO:0006120

GO:0006605

GO:0006810

GO:0006915

GO:0007005

GO:0007165

GO:0008137

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0010952

GO:0015031

GO:0016020

GO:0016021

GO:0016032

GO:0016491

GO:0022607

GO:0030308

GO:0031966

GO:0032981

GO:0032991

GO:0034641

GO:0035458

GO:0040007

GO:0043167

GO:0043226

GO:0043280

GO:0044403

GO:0045039

GO:0045732

GO:0045892

GO:0055114

GO:0061024

GO:0065003

GO:0070469

GO:0071300

GO:0072593

GO:0097190

GO:0097191

GO:2001243

PH_hs_0032456

g7705733_3p_a_at

Participant Of

hasComponent

HP subcomplex [mitochondrial inner membrane]

Inferred To

NDUFA13 [mitochondrial inner membrane] (Bos taurus)

NDUFA13 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFA13 [mitochondrial inner membrane] (Canis familiaris)

NDUFA13 [mitochondrial inner membrane] (Gallus gallus)

NDUFA13 [mitochondrial inner membrane] (Sus scrofa)

Ghost homologue of NDUFA13 [mitochondrial inner membrane] (Danio rerio)

ndufa13 [mitochondrial inner membrane] (Xenopus tropicalis)

Ndufa13 [mitochondrial inner membrane] (Mus musculus)

Ndufa13 [mitochondrial inner membrane] (Rattus norvegicus)

ND-B16.6 [mitochondrial inner membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_057049.5

Target Pathogen

5b354852be737e166372eb2d

OpenTargets

ENSG00000186010

HPA

ENSG00000186010-NDUFA13

GeneCards

Q9P0J0

Ensembl

ENSG00000186010, ENSP00000423673, ENST00000507754

PRO

Q9P0J0

Orphanet

22591

HMDB Protein

HMDBP00190

PDB

5XTH, 5XTC, 5XTI, 5XTD, 5XTB

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:Q9P032 NDUFAF4	1	NDUFAF4 [mitochondrial inner membrane] (R-HSA-5689124)	0.643	4
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.543	6
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.527	3
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2
UniProt:O75489 NDUFS3	1	NDUFS3 [mitochondrial matrix] (R-HSA-163927)	0.527	6
UniProt:O43181 NDUFS4	1	NDUFS4 [mitochondrial inner membrane] (R-HSA-163946)	0.527	2

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