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ITGB3BP [nucleoplasm]
Stable Identifier
R-HSA-606325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Centromere protein R, CENPR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Nucleosome assembly (Homo sapiens)
Deposition of new CENPA-containing nucleosomes at the centromere (Homo sapiens)
HJURP:CENPA complex localizes to the centromere (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
Mis18 complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
RSF complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)
Ubiquitinated NRIF:Sequestosome [nucleoplasm] (Homo sapiens)
ITGB3BP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13352 ITGB3BP
Gene Names
ITGB3BP, CENPR, NRIF3
Chain
chain:1-177
Reference Genes
BioGPS Gene:23421 ITGB3BP
COSMIC (genes):ITGB3BP ITGB3BP
CTD Gene:23421 ITGB3BP
dbSNP Gene:23421 ITGB3BP
ENSEMBL:ENSG00000142856 ITGB3BP
HGNC:6157 ITGB3BP
KEGG Gene (Homo sapiens):23421 ITGB3BP
Monarch:23421 ITGB3BP
NCBI Gene:23421 ITGB3BP
OMIM:605494 ITGB3BP
UCSC:Q13352 ITGB3BP
Reference Transcript
RefSeq:NM_014288.4 ITGB3BP
RefSeq:NM_001347148.1 ITGB3BP
RefSeq:NM_001206739.1 ITGB3BP
Other Identifiers
0001980044
11738703_a_at
11744511_x_at
11745297_x_at
205176_s_at
23421
2416219
2416220
2416223
2416225
2416234
2416235
2416236
2416242
2416245
2416246
2416249
2416250
2416252
38501_s_at
40676_at
7916727
A_23_P23765
GE59112
GO:0000775
GO:0000776
GO:0000777
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006915
GO:0007049
GO:0007155
GO:0007165
GO:0008022
GO:0008150
GO:0008219
GO:0009058
GO:0016020
GO:0022607
GO:0034080
GO:0034641
GO:0043065
GO:0043226
GO:0051276
GO:0051301
GO:0065003
ILMN_1692790
PH_hs_0019190
PH_hs_0035905
U37139_at
g7657205_3p_a_at
Participant Of
hasComponent
CCAN [nucleoplasm]
Ubiquitinated NRIF:Sequestosome [nucleoplasm]
Other forms of this molecule
ITGB3BP [cytosol]
Inferred To
ITGB3BP [nucleoplasm] (Bos taurus)
ITGB3BP [nucleoplasm] (Gallus gallus)
Itgb3bp [nucleoplasm] (Mus musculus)
Itgb3bp [nucleoplasm] (Rattus norvegicus)
si:dkey-148h10.5 [nucleoplasm] (Danio rerio)
Ghost homologue of ITGB3BP [nucleoplasm] (Canis familiaris)
Ghost homologue of ITGB3BP [nucleoplasm] (Sus scrofa)
Cross References
RefSeq
NP_001193668.1
,
NP_001334077.1
,
NP_055103.3
OpenTargets
ENSG00000142856
HPA
ENSG00000142856-ITGB3BP
GeneCards
Q13352
Ensembl
ENST00000271002
,
ENSP00000360133
,
ENSG00000142856
,
ENSP00000432904
,
ENST00000489099
,
ENSP00000271002
,
ENST00000371092
PRO
Q13352
HMDB Protein
HMDBP01805
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5P4 CERT1
0.666
4
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.666
4
UniProt:Q8WWB5 PIHD2
0.666
7
UniProt:O75031 HSF2B
0.556
3
UniProt:P22607 FGFR3
40
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 795fs*139 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
p-6Y-FGFR3 S371C [plasma membrane]
(R-HSA-2011886)
p-6Y-FGFR3 G370C [plasma membrane]
(R-HSA-2011883)
p-6Y-FGFR3 Y373C [plasma membrane]
(R-HSA-2011889)
p-6Y-FGFR3 795fs*139 [plasma membrane]
(R-HSA-2038360)
p-6Y-FGFR3 R248C [plasma membrane]
(R-HSA-2011884)
pY-FGFR3 [plasma membrane]
(R-HSA-2038368)
p-6Y-FGFR3 K650Q [plasma membrane]
(R-HSA-2032962)
p-6Y-FGFR3 K650N [plasma membrane]
(R-HSA-2032961)
p-6Y-FGFR3 K650E [plasma membrane]
(R-HSA-2032952)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853147)
p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853155)
p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853145)
p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853129)
p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853151)
p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853128)
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
0.556
3
UniProt:Q9NWQ9 CN119
0.556
3
UniProt:Q9H7Z3 NRDE2
0.556
3
UniProt:P14927 UQCRB
1
UQCRB [mitochondrial inner membrane]
(R-HSA-164287)
0.556
3
UniProt:Q8N7C3 TRIMM
0.556
3
UniProt:O14770-4 MEIS2
0.556
3
UniProt:P51687 SUOX
1
SUOX [mitochondrial matrix]
(R-HSA-1614570)
0.556
3
UniProt:P45984 MAPK9
3
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.556
3
UniProt:A6NI15 MSGN1
0.556
3
UniProt:Q9BVL2 NUP58
0.556
6
UniProt:Q92569 PIK3R3
2
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
PIK3R3 [cytosol]
(R-HSA-205223)
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:O75971-2 SNAPC5
0.556
3
UniProt:Q9BVG8 KIFC3
0.556
3
UniProt:Q5JVL4 EFHC1
0.556
3
UniProt:P62491 RAB11A
4
GGC-RAB11A [cytosol]
(R-HSA-8873781)
RAB11A [recycling endosome membrane]
(R-HSA-2029023)
RAB11A [cytosol]
(R-HSA-5623395)
GGC-RAB11A [cytoplasmic vesicle membrane]
(R-HSA-1458519)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:P01112 HRAS
23
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
proHRAS [cytosol]
(R-HSA-9647765)
S-Farn-proHRAS [endoplasmic reticulum membrane]
(R-HSA-9647918)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-HSA-9647912)
0.556
3
UniProt:Q96AL5 Q96AL5
0.556
3
UniProt:Q13449 LSAMP
2
GPI-LSAMP [plasma membrane]
(R-HSA-8940809)
cleaved GPI-LSAMP [extracellular region]
(R-HSA-8941032)
0.556
3
UniProt:P50440 GATM
1
GATM [mitochondrial intermembrane space]
(R-HSA-71267)
0.556
3
UniProt:Q969Y2 GTPBP3
1
GTPBP3 [mitochondrial matrix]
(R-HSA-6787414)
0.556
3
UniProt:Q00613 HSF1
11
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
HSF1 [cytosol]
(R-HSA-3371452)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
0.556
3
UniProt:P01100 FOS
2
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
FOS [nucleoplasm]
(R-HSA-450216)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.556
3
UniProt:A0A024R8A9 A0A024R8A9
0.556
3
UniProt:O14901 KLF11
0.556
6
UniProt:O14645 IDLC
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:X5D778 X5D778
0.556
3
UniProt:Q6ICG6-3 KIAA0930
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
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