Reactome | PPP3CC [cytosol]

PPP3CC [cytosol]

Stable Identifier

R-HSA-61113

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Calcineurin B gamma, catalytic, Serine/threonine protein phosphatase 2B catalytic subunit, gamma isoform , Calmodulin-dependent calcineurin A subunit, gamma isoform, Calcineurin, testis-specific catalytic subunit, CAM-PRP catalytic subunit

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of BAD and translocation to mitochondria (Homo sapiens)
        
        Activation of BAD by calcineurin (Homo sapiens)
        
        Calcineurin B complex [cytosol] (Homo sapiens)
        
        PPP3CC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48454 PPP3CC

Gene Names

PPP3CC, CALNA3, CNA3

Chain

chain:1-512

Reference Genes

BioGPS Gene:5533 PPP3CC

COSMIC (genes):PPP3CC PPP3CC

CTD Gene:5533 PPP3CC

dbSNP Gene:5533 PPP3CC

ENSEMBL:ENSG00000120910 PPP3CC

HGNC:9316 PPP3CC

KEGG:hsa:5533 PPP3CC

Monarch:5533 PPP3CC

NCBI Gene:5533 PPP3CC

OMIM:114107 PPP3CC

UCSC:P48454 PPP3CC

Reference Transcript

Other Identifiers

11722420_a_at

17066627

207000_PM_s_at

207000_s_at

3089402

3089403

3089404

3089408

3089409

3089410

3089411

3089427

3089428

3089429

3089430

3089431

3089433

3089434

3089436

3089437

3089438

3089439

3089440

3089441

3089443

3089444

3089445

3089448

3089449

3089450

3089458

3089461

3089462

3089463

32541_PM_at

32541_at

5533

8145136

A_14_P119710

A_23_P157495

GE58778

GO:0003824

GO:0004721

GO:0004722

GO:0004723

GO:0005515

GO:0005516

GO:0005737

GO:0005739

GO:0005829

GO:0005955

GO:0006470

GO:0008287

GO:0016787

GO:0017018

GO:0033173

GO:0033192

GO:0043226

GO:0046872

GO:0070886

GO:0097720

GO:0098793

GO:0098978

GO:0140096

GO:1900242

GO:1900244

GO:1905665

GO:1905949

HMNXSV003014039

HMNXSV003045682

ILMN_1690546

PH_hs_0004287

S46622_at

TC08000172.hg

g5031988_3p_s_at

Participates

as a member of

PPP3CA,B,C [cytosol] (Homo sapiens)

as a component of

Calcineurin B complex [cytosol] (Homo sapiens)

Inferred To

ppp3cb [cytosol] (Xenopus tropicalis)

PPP3CC [cytosol] (Bos taurus)

PPP3CC [cytosol] (Canis familiaris)

PPP3CC [cytosol] (Mus musculus)

PPP3CC [cytosol] (Sus scrofa)

Ppp3cc [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001230903.1, NP_001230904.1, NP_005596.2

ENSEMBL

ENSP00000240139, ENSP00000289963, ENST00000240139, ENST00000289963, ENSP00000380878, ENST00000397775

OpenTargets

ENSG00000120910

HPA

ENSG00000120910-PPP3CC

PRO

P48454

Pharos - Targets

P48454

HMDB Protein

HMDBP07950

PDB

7U0T

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9UKA8 RCAN3	1	RCAN3 [cytosol] (R-HSA-9728800)	0.527	3
UniProt:P59665 DEFA1	9	DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.527	3
UniProt:P05814 CSN2	1	CSN2 [extracellular region] (R-HSA-1254293)	0.527	2
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.527	3

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