Reactome | TRPC1 [plasma membrane]

TRPC1 [plasma membrane]

Stable Identifier

R-HSA-612168

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Short transient receptor potential channel 1, TRPC1_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Netrin-1 signaling (Homo sapiens)
      - Role of second messengers in netrin-1 signaling (Homo sapiens)
        
        Activation of TRPC channels by Netrin-1 (Homo sapiens)
        
        Activated TRP channels [plasma membrane] (Homo sapiens)
        
        TRPC1+4/5 [plasma membrane] (Homo sapiens)
        
        TRPC1 [plasma membrane] (Homo sapiens)
        
        TRPC channels [plasma membrane] (Homo sapiens)
        
        TRPC1+4/5 [plasma membrane] (Homo sapiens)
        
        TRPC1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48995 TRPC1

Gene Names

TRPC1, TRP1

Chain

chain:1-793

Reference Genes

BioGPS Gene:7220 TRPC1

COSMIC (genes):TRPC1 TRPC1

CTD Gene:7220 TRPC1

dbSNP Gene:7220 TRPC1

ENSEMBL:ENSG00000144935 TRPC1

HGNC:12333 TRPC1

KEGG Gene (Homo sapiens):7220 TRPC1

Monarch:7220 TRPC1

NCBI Gene:7220 TRPC1

OMIM:602343 TRPC1

UCSC:P48995 TRPC1

Reference Transcript

Other Identifiers

0000050341

11722543_at

16946513

205802_at

205803_s_at

211602_s_at

2645952

2645953

2645954

2645961

2645964

2645966

2645967

2645975

2645976

2645979

2645981

2645982

2645983

2645985

2645986

2645989

2645990

2645991

2645993

2645994

39123_s_at

39124_r_at

7220

8083166

A_14_P117870

A_24_P28977

GE60118

GO:0003013

GO:0003674

GO:0005102

GO:0005216

GO:0005261

GO:0005262

GO:0005515

GO:0005575

GO:0005886

GO:0005887

GO:0006810

GO:0006811

GO:0006816

GO:0006828

GO:0008150

GO:0009058

GO:0015279

GO:0016020

GO:0016021

GO:0019748

GO:0019899

GO:0022857

GO:0032991

GO:0034703

GO:0042438

GO:0042592

GO:0043167

GO:0043235

GO:0044325

GO:0051117

GO:0051281

GO:0051480

GO:0051592

GO:0055085

GO:0070588

GO:0070679

GO:1903779

HMNXSV003014745

HMNXSV003021345

ILMN_1674380

PH_hs_0013274

TC03000770.hg

X89066_at

g1072042_3p_s_at

g4507684_3p_at

Participates

as a member of

TRPs [plasma membrane] (Homo sapiens)

as a component of

TRPC1+4/5 [plasma membrane] (Homo sapiens)

Other forms of this molecule

TRPC1 [plasma membrane]

Inferred To

Homologues of TRPC1 [plasma membrane] (Drosophila melanogaster)

trpl [plasma membrane] (Drosophila melanogaster)

trp [plasma membrane] (Drosophila melanogaster)

trp-2 [plasma membrane] (Caenorhabditis elegans)

trpc1 [plasma membrane] (Danio rerio)

Trpc1 [plasma membrane] (Mus musculus)

Trpc1 [plasma membrane] (Rattus norvegicus)

TRPC1 [plasma membrane] (Canis familiaris)

TRPC1 [plasma membrane] (Gallus gallus)

TRPC1 [plasma membrane] (Sus scrofa)

Trpgamma [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_003295.1, NP_001238774.1

OpenTargets

ENSG00000144935

HPA

ENSG00000144935-TRPC1

GeneCards

P48995

Ensembl

ENST00000612385, ENST00000273482, ENSP00000481537, ENSG00000144935, ENSP00000419313, ENST00000476941, ENSP00000273482

PRO

P48995

HMDB Protein

HMDBP08075

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13563 PKD2	3	PKD2 [Golgi-associated vesicle membrane] (R-HSA-5623411) PKD2 [ciliary membrane] (R-HSA-5623409) PKD2 [Golgi membrane] (R-HSA-5623393)	0.69	12
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.641	6
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.633	7