Reactome | PDPK1 [plasma membrane]

PDPK1 [plasma membrane]

Stable Identifier

R-HSA-61459

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PDK1, 3-phosphoinositide dependent protein kinase-1

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Locations in the PathwayBrowser for interactor UniProt:O95704 APBB3

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 binds PIP3 (Homo sapiens)
        
        PDPK1 [plasma membrane] (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 binds PIP3 (Homo sapiens)
        
        PDPK1 [plasma membrane] (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated cell proliferation (Homo sapiens)
        
        PDK1 phosphorylates PKC (Homo sapiens)
        
        PDPK1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15530 PDPK1

Gene Names

PDPK1, PDK1

Chain

chain:1-556

Reference Genes

BioGPS Gene:5170 PDPK1

COSMIC (genes):PDK1 PDPK1

COSMIC (genes):PDPK1 PDPK1

CTD Gene:5170 PDPK1

dbSNP Gene:5170 PDPK1

ENSEMBL:ENSG00000140992 PDPK1

HGNC:8816 PDPK1

KEGG:hsa:5170 PDPK1

Monarch:5170 PDPK1

NCBI Gene:5170 PDPK1

OMIM:605213 PDPK1

UCSC:O15530 PDPK1

Reference Transcript

Participates

as a member of

AKT1/PDK1 [plasma membrane] (Homo sapiens)

as a component of

as an input of

Other forms of this molecule

PDPK1 [cytosol]

p-S241-PDPK1 [cytosol]

Inferred To

PDPK1 [plasma membrane] (Bos taurus)

PDPK1 [plasma membrane] (Caenorhabditis elegans)

PDPK1 [plasma membrane] (Canis familiaris)

PDPK1 [plasma membrane] (Danio rerio)

PDPK1 [plasma membrane] (Dictyostelium discoideum)

PDPK1 [plasma membrane] (Drosophila melanogaster)

PDPK1 [plasma membrane] (Gallus gallus)

PDPK1 [plasma membrane] (Mus musculus)

PDPK1 [plasma membrane] (Plasmodium falciparum)

PDPK1 [plasma membrane] (Rattus norvegicus)

PDPK1 [plasma membrane] (Saccharomyces cerevisiae)

PDPK1 [plasma membrane] (Schizosaccharomyces pombe)

PDPK1 [plasma membrane] (Sus scrofa)

PDPK1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_112558.2, NP_001248745.1, NP_002604.1

Guide to Pharmacology - Targets

1519

OpenTargets

ENSG00000140992

ENSEMBL

ENSP00000344220, ENST00000268673, ENST00000342085, ENST00000441549, ENSP00000268673, ENSP00000395357, ENSG00000140992

ZINC - FDA approved

PDPK1_HUMAN

ZINC - Substances

PDPK1_HUMAN

ZINC - Biogenic

PDPK1_HUMAN

ZINC target

O15530

PRO

O15530

PDB

3RWQ, 5ACK, 4RRV, 6WJQ, 3HRC, 1UU8, 3QCQ, 2VKI, 3QCX, 3H9O, 1Z5M, 3ORZ, 4A07, 4A06, 1W1H, 4RQV, 1W1D, 2PE1, 3QCS, 2XCH, 1W1G, 4CT1, 8DQT, 3ION, 3NUU, 3SC1, 5LVM, 4RQK, 1OKY, 1UVR, 5LVO, 4CT2, 4XX9, 5HO8, 4AW1, 3RWP, 3QD0, 3NAX, 3PWY, 3HRF, 3QD3, 1UU7, 3QCY, 3NAY, 5MRD, 1UU3, 5HKM, 3NUN, 3NUS, 2PE0, 2PE2, 3ORX, 3OTU, 3QD4, 3NUY, 3IOP, 2XCK, 3QC4, 2R7B, 1UU9, 5LVN, 1OKZ, 5LVL, 5LVP, 3RCJ, 5HNG, 1H1W, 2BIY, 5HO7, 4AW0

ZINC - Investigational

PDPK1_HUMAN

ZINC - Metabolites

PDPK1_HUMAN

HPA

ENSG00000140992-PDPK1

GeneCards

PDPK1

Pharos - Targets

O15530

ZINC - Predictions - Purchasable

PDPK1_HUMAN

HMDB Protein

HMDBP01430

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.767	4
UniProt:Q9Y4P3 TBL2			0.623	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.564	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.544	3
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) SDC1 [Golgi lumen] (R-HSA-2054105) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349) Heparan-SDC1 [Golgi lumen] (R-HSA-2076561)	0.527	3
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.527	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) SDC2 [Golgi lumen] (R-HSA-2054101) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536)	0.527	2
UniProt:P35052 GPC1	20	HS(4)-GPC1 [plasma membrane] (R-HSA-2076668) HS(6)-GPC1 [plasma membrane] (R-HSA-2076629) HS(2)-GPC1 [plasma membrane] (R-HSA-2076632) HS(1)-GPC1 [plasma membrane] (R-HSA-2076645) HS(3)-GPC1 [plasma membrane] (R-HSA-2076636) HS(5)-GPC1 [plasma membrane] (R-HSA-2076648) GPC1 [plasma membrane] (R-HSA-425952) GPC1 [Golgi lumen] (R-HSA-2054106) XylS-GPC1 [Golgi lumen] (R-HSA-2064041) Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064076) Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064144) GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064189) HS(2)-GPC1 [Golgi lumen] (R-HSA-2076296) HS(3)-GPC1 [Golgi lumen] (R-HSA-2076340) HS(1)-GPC1 [Golgi lumen] (R-HSA-2076424) Heparan(4)-GPC1 [Golgi lumen] (R-HSA-2076605) Heparan(3)-GPC1 [Golgi lumen] (R-HSA-2076503) Heparan(2)-GPC1 [Golgi lumen] (R-HSA-2076501) Heparan(1)-GPC1 [Golgi lumen] (R-HSA-2076476) Heparan-GPC1 [Golgi lumen] (R-HSA-2076567)	0.527	2
UniProt:Q9BZF1 OSBPL8	1	OSBPL8 [cytosol] (R-HSA-8867870)	0.527	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	3
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.527	2
UniProt:O75487 GPC4	20	HS(4)-GPC4 [plasma membrane] (R-HSA-2076638) HS(6)-GPC4 [plasma membrane] (R-HSA-2076677) HS(2)-GPC4 [plasma membrane] (R-HSA-2076662) HS(1)-GPC4 [plasma membrane] (R-HSA-2076673) HS(3)-GPC4 [plasma membrane] (R-HSA-2076697) HS(5)-GPC4 [plasma membrane] (R-HSA-2076658) GPC4 [Golgi lumen] (R-HSA-2054108) XylS-GPC4 [Golgi lumen] (R-HSA-2064173) Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064060) Gal-Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064030) GlcA-Gal-Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064215) HS(2)-GPC4 [Golgi lumen] (R-HSA-2076336) HS(3)-GPC4 [Golgi lumen] (R-HSA-2076439) HS(1)-GPC4 [Golgi lumen] (R-HSA-2076401) Heparan(4)-GPC4 [Golgi lumen] (R-HSA-2076440) Heparan(3)-GPC4 [Golgi lumen] (R-HSA-2076612) Heparan(2)-GPC4 [Golgi lumen] (R-HSA-2076555) Heparan(1)-GPC4 [Golgi lumen] (R-HSA-2076560) Heparan-GPC4 [Golgi lumen] (R-HSA-2076475) HS(4)-GPC4 [Golgi lumen] (R-HSA-2076368)	0.527	2
UniProt:Q6A1A2 PDPK2			0.527	3
UniProt:O00468 AGRN	20	HS(4)-AGRN [plasma membrane] (R-HSA-2076654) HS(6)-AGRN [plasma membrane] (R-HSA-2076678) HS(2)-AGRN [plasma membrane] (R-HSA-2076686) HS(1)-AGRN [plasma membrane] (R-HSA-2076634) HS(3)-AGRN [plasma membrane] (R-HSA-2076663) HS(5)-AGRN [plasma membrane] (R-HSA-2076642) AGRN(30-2045) [extracellular region] (R-HSA-375056) AGRN(30-2045) [Golgi lumen] (R-HSA-2054104) XylS-AGRN(30-2045) [Golgi lumen] (R-HSA-2064220) Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064130) Gal-Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064040) GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064200) HS(2)-AGRN [Golgi lumen] (R-HSA-2076521) HS(3)-AGRN [Golgi lumen] (R-HSA-2076493) HS(1)-AGRN [Golgi lumen] (R-HSA-2076350) Heparan(4)-AGRN [Golgi lumen] (R-HSA-2076300) Heparan(3)-AGRN [Golgi lumen] (R-HSA-2076569) Heparan(2)-AGRN [Golgi lumen] (R-HSA-2076301) Heparan(1)-AGRN [Golgi lumen] (R-HSA-2076317) Heparan-AGRN [Golgi lumen] (R-HSA-2076530)	0.527	2
UniProt:O75116 ROCK2	2	ROCK2 [cytosol] (R-HSA-419058) Activated ROCK2 [cytosol] (R-HSA-4687775)	0.527	2
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	4
UniProt:P31431 SDC4	20	HS(4)-SDC4 [plasma membrane] (R-HSA-2076670) HS(6)-SDC4 [plasma membrane] (R-HSA-2076633) HS(2)-SDC4 [plasma membrane] (R-HSA-2076694) HS(1)-SDC4 [plasma membrane] (R-HSA-2076653) HS(3)-SDC4 [plasma membrane] (R-HSA-2076674) HS(5)-SDC4 [plasma membrane] (R-HSA-2076635) SDC4 [Golgi lumen] (R-HSA-2054111) XylS-SDC4 [Golgi lumen] (R-HSA-2064195) Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064249) Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064100) GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064067) HS(2)-SDC4 [Golgi lumen] (R-HSA-2076411) HS(3)-SDC4 [Golgi lumen] (R-HSA-2076418) HS(1)-SDC4 [Golgi lumen] (R-HSA-2076434) Heparan(4)-SDC4 [Golgi lumen] (R-HSA-2076613) Heparan(3)-SDC4 [Golgi lumen] (R-HSA-2076460) Heparan(2)-SDC4 [Golgi lumen] (R-HSA-2076446) Heparan(1)-SDC4 [Golgi lumen] (R-HSA-2076394) Heparan-SDC4 [Golgi lumen] (R-HSA-2076374) HS(4)-SDC4 [Golgi lumen] (R-HSA-2076407)	0.527	3
UniProt:P09038 FGF2	1	FGF2(10-155) [extracellular region] (R-HSA-189898)	0.527	2
UniProt:Q92896 GLG1	1	GLG1 [plasma membrane] (R-HSA-2870220)	0.527	3
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.527	3
UniProt:Q00005 2ABB			0.524	8
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.488	2
UniProt:O95704 APBB3			0.488	2

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