Reactome | PPP1CB [nucleoplasm]

PPP1CB [nucleoplasm]

Stable Identifier

R-HSA-62003

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Serine/threonine protein phosphatase PP1-beta catalytic subunit , PP-1B

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62140 PPP1CB

Gene Names

PPP1CB

Chain

initiator methionine:1, chain:2-327

Reference Genes

BioGPS Gene:5500 PPP1CB

COSMIC (genes):PPP1CB PPP1CB

CTD Gene:5500 PPP1CB

dbSNP Gene:5500 PPP1CB

ENSEMBL:ENSG00000213639 PPP1CB

HGNC:9282 PPP1CB

KEGG Gene (Homo sapiens):5500 PPP1CB

Monarch:5500 PPP1CB

NCBI Gene:5500 PPP1CB

OMIM:600590 PPP1CB

Reference Transcript

Other Identifiers

0000380026

11725614_s_at

11725615_a_at

11725616_at

11746720_a_at

11757308_s_at

16878522

201407_s_at

201408_at

201409_s_at

2475210

2475211

2475212

2475213

2475214

2475226

2475228

2475232

2475233

2475237

2475241

2475242

2475244

2475245

2475246

2475247

2475248

2475249

2475250

2475251

5500

78737_at

8041122

A_24_P396720

A_24_P405298

GE60066

GO:0000086

GO:0000164

GO:0000228

GO:0000278

GO:0000784

GO:0003674

GO:0004721

GO:0004722

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0005925

GO:0005975

GO:0005977

GO:0005979

GO:0005981

GO:0006091

GO:0006464

GO:0006470

GO:0007049

GO:0007155

GO:0008150

GO:0009056

GO:0009058

GO:0016787

GO:0016791

GO:0017018

GO:0019899

GO:0019901

GO:0030155

GO:0032922

GO:0032991

GO:0042587

GO:0042752

GO:0043153

GO:0043167

GO:0043226

GO:0044281

GO:0046872

GO:0048511

GO:0050115

GO:0051301

GO:0070062

GO:0072357

Hs.21537.0.S2_3p_a_at

Hs.21537.0.S4_3p_s_at

ILMN_1736942

ILMN_2405018

ILMN_2405023

PH_hs_0001870

TC02004955.hg

X80910_at

g4506004_3p_a_at

Participant Of

hasComponent

Phosphorylated Myosin Phosphatase [nucleoplasm]

Other forms of this molecule

PPP1CB A56P [cytosol]

PPP1CB P49R [cytosol]

PPP1CB [cytosol]

Inferred To

ppp1cbl [nucleoplasm] (Danio rerio)

Ppp1cb [nucleoplasm] (Mus musculus)

Ppp1cb [nucleoplasm] (Rattus norvegicus)

Homologues of PPP1CB [nucleoplasm] (Danio rerio)

flw [nucleoplasm] (Drosophila melanogaster)

gsp-1 [nucleoplasm] (Caenorhabditis elegans)

ppp1cb [nucleoplasm] (Danio rerio)

ppp1cb [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002700.1, NP_996759.1

OpenTargets

ENSG00000213639

IntEnz

3.1.3.53

GeneCards

P62140

HPA

ENSG00000213639-PPP1CB

Ensembl

ENSP00000351298, ENST00000395366, ENSP00000378769, ENSG00000213639, ENST00000296122, ENST00000358506, ENSP00000296122

PRO

P62140

Orphanet

24822

HMDB Protein

HMDBP01775

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.83	6
UniProt:Q9UQK1 PPP1R3C	2	PPP1R3C [cytosol] (R-HSA-3777102) K48polyUb-PPP1R3C [cytosol] (R-HSA-3781005)	0.782	9
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.69	4
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.638	3
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.597	3
UniProt:P38398 BRCA1	5	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) BRCA1 [nucleoplasm] (R-HSA-50949) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.581	3
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910)	0.556	3
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.508	2
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.508	2
UniProt:O08785 Clock	2	p-S-Clock [nucleoplasm] (R-MMU-508670) Clock [cytosol] (R-MMU-508720)	0.508	2
UniProt:Q8NI77 KIF18A	1	KIF18A [cytosol] (R-HSA-376239)	0.508	2
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.463	2
UniProt:Q14974 KPNB1	5	KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.462	2