Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PPP1CB [nucleoplasm]
Stable Identifier
R-HSA-62003
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Serine/threonine protein phosphatase PP1-beta catalytic subunit , PP-1B
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)
Phosphorylated Myosin Phosphatase [nucleoplasm] (Homo sapiens)
PPP1CB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62140 PPP1CB
Gene Names
PPP1CB
Chain
initiator methionine:1, chain:2-327
Reference Genes
BioGPS Gene:5500 PPP1CB
COSMIC (genes):PPP1CB PPP1CB
CTD Gene:5500 PPP1CB
dbSNP Gene:5500 PPP1CB
ENSEMBL:ENSG00000213639 PPP1CB
HGNC:9282 PPP1CB
KEGG Gene (Homo sapiens):5500 PPP1CB
Monarch:5500 PPP1CB
NCBI Gene:5500 PPP1CB
OMIM:600590 PPP1CB
Reference Transcript
RefSeq:NM_206876.1 PPP1CB
RefSeq:NM_002709.2 PPP1CB
Other Identifiers
0000380026
04658+3.1.3.16
04660+3.1.3.16
11725614_s_at
11725615_a_at
11725616_at
11746720_a_at
11757308_s_at
16878522
201407_s_at
201408_at
201409_s_at
22558
2475210
2475211
2475212
2475213
2475214
2475226
2475228
2475232
2475233
2475237
2475241
2475242
2475244
2475245
2475246
2475247
2475248
2475249
2475250
2475251
5500
65425
69426
78737_at
8041122
A_24_P396720
A_24_P405298
AAA85093
AAF01137
AAH02697
AAH12045
AAV38549
AAY24124
AC097724
ACF94492
AF092905
AK312329
BAG35251
BC002697
BC012045
BT019744
BX647970
C9J9S3
C9JP48
CAA56870
CAB022558
CAB069426
CAG47059
CAG47080
CCDS33169
CH471053
CR542263
CR542285
E7ETD8
EAX00527
EAX00528
EAX00529
EAX00530
ENSG00000213639
ENSP00000296122
ENSP00000351298
ENSP00000378769
ENST00000296122
ENST00000296122.10
ENST00000358506
ENST00000358506.6
ENST00000395366
ENST00000395366.2
EntrezGene:5500
EntrezGene:PPP1CB
EU668339
F8WE71
g4506004_3p_a_at
GE60066
GO:0000086
GO:0000164
GO:0000228
GO:0000278
GO:0000784
GO:0003674
GO:0004721
GO:0004722
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0005925
GO:0005975
GO:0005977
GO:0005979
GO:0005981
GO:0006091
GO:0006464
GO:0006470
GO:0007049
GO:0007155
GO:0008150
GO:0009056
GO:0009058
GO:0016787
GO:0016791
GO:0017018
GO:0019899
GO:0019901
GO:0030155
GO:0032922
GO:0032991
GO:0042587
GO:0042752
GO:0043153
GO:0043167
GO:0043226
GO:0044281
GO:0046872
GO:0048511
GO:0050115
GO:0051301
GO:0070062
GO:0072357
H0Y3Y6
HEL-S-80p
HGNC:9282
HPA065425
Hs.21537.0.S2_3p_a_at
Hs.21537.0.S4_3p_s_at
ILMN_1736942
ILMN_2405018
ILMN_2405023
IPR004843
IPR006186
IPR029052
IPR031675
MIM:600590
MIM:617506
NM_002709
NM_206876
NP_002700
NP_996759
PF00149
PF16891
PH_hs_0001870
PPP1CB
PPP1CB-201
PPP1CB-202
PPP1CB-203
PR00114
SM00156
TC02004955.hg
U10998
U10999
U11000
U11001
U11002
U11003
U11004
U11005
UPI000000007B
V9HW04
X80910
X80910_at
Participant Of
hasComponent
Phosphorylated Myosin Phosphatase [nucleoplasm]
Other forms of this molecule
PPP1CB [cytosol]
Inferred To
PPP1CB [nucleoplasm] (Caenorhabditis elegans)
PPP1CB [nucleoplasm] (Danio rerio)
PPP1CB [nucleoplasm] (Drosophila melanogaster)
PPP1CB [nucleoplasm] (Mus musculus)
PPP1CB [nucleoplasm] (Rattus norvegicus)
PPP1CB [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_002700.1
,
NP_996759.1
OpenTargets
ENSG00000213639
IntEnz
3.1.3.53
,
3.1.3.16
GeneCards
P62140
PRO
P62140
Orphanet
24822
HMDB Protein
HMDBP01775
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WUF5 PPP1R13L
1
PPP1R13L [nucleoplasm]
(R-HSA-6799738)
0.83
6
UniProt:Q9UQK1 PPP1R3C
2
PPP1R3C [cytosol]
(R-HSA-3777102)
K48polyUb-PPP1R3C [cytosol]
(R-HSA-3781005)
0.766
6
UniProt:Q5UIP0 RIF1
1
RIF1 [nucleoplasm]
(R-HSA-480742)
0.69
4
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.638
3
UniProt:Q9BZF9 UACA
1
UACA [cytosol]
(R-HSA-6804636)
0.597
3
UniProt:P38398 BRCA1
5
SUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
SUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-5683800)
BRCA1 [nucleoplasm]
(R-HSA-50949)
p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-75234)
0.581
3
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.508
2
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.508
2
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.508
2
UniProt:Q8NI77 KIF18A
1
KIF18A [cytosol]
(R-HSA-376239)
0.508
2
UniProt:Q9NX63 CHCHD3
3
CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874907)
CHCHD3 (MIC19) [mitochondrial inner membrane]
(R-HSA-8949583)
4xHC-CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874910)
0.488
2
UniProt:P19338 NCL
1
NCL [nucleoplasm]
(R-HSA-6791213)
0.463
2
UniProt:Q14974 KPNB1
5
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
0.462
2
© 2019
Reactome