Activation of highly calcium permeable nicotinic acetylcholine receptors

Stable Identifier
R-HSA-622326
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Nicotinic acetylcholine receptors are activated upon ligand binding which opens the acetylcholine channels and permits Ca2+ and Na+ ion influx depending on the subunit composition and stoichiometry of the subunits. The ratio of Ca2+ to Na+ ion influx varies making the receptors either highly Na+ permeable or Ca2+ permeable.

Literature References
PubMed ID Title Journal Year
12810063 Fractional Ca(2+) current through human neuronal alpha7 nicotinic acetylcholine receptors

Fucile, S, Renzi, M, Lax, P, Eusebi, F

Cell Calcium 2003
10945867 Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine

Grottick, AJ, Trube, G, Corrigall, WA, Huwyler, J, Malherbe, P, Wyler, R, Higgins, GA

J Pharmacol Exp Ther 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ligand-gated ion channel activity of 0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created