RIP2 binds NEMO

Stable Identifier
R-HSA-622415
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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RIP2 binds NEMO
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An intermediate region located between the CARD and kinase domains mediates the interaction of RIP2 with the IKK complex regulatory subunit NEMO. This interaction is presumed to link NOD1:RIP2 to the IKK complex, ultimately leading to the phosphorylation of IkappaB-alpha and the activation of NF-kappaB (Inohara et al. 2000). Although every NOD molecule in the oligomeric complex is represented as binding RIP2, binding to every member of the complex may not be required for subsequent signaling events.
Literature References
PubMed ID Title Journal Year
18079694 A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

Hasegawa, M, Nakano, H, Lucas, PC, Nunez, G, Fujimoto, Y, Inohara, N, Fukase, K

EMBO J 2008
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Orthologous Events
RIP2 binds NEMO (Bos taurus)
RIP2 binds NEMO (Canis familiaris)
RIP2 binds NEMO (Danio rerio)
RIP2 binds NEMO (Mus musculus)
RIP2 binds NEMO (Rattus norvegicus)
RIP2 binds NEMO (Xenopus tropicalis)
Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-04-23)
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