RIP2 binds NEMO

Stable Identifier
R-HSA-622415
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

An intermediate region located between the CARD and kinase domains mediates the interaction of RIP2 with the IKK complex regulatory subunit NEMO. This interaction is presumed to link NOD1:RIP2 to the IKK complex, ultimately leading to the phosphorylation of IkappaB-alpha and the activation of NF-kappaB (Inohara et al. 2000). Although every NOD molecule in the oligomeric complex is represented as binding RIP2, binding to every member of the complex may not be required for subsequent signaling events.

Literature References
PubMed ID Title Journal Year
18079694 A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

Hasegawa, M, Fujimoto, Y, Lucas, PC, Nakano, H, Fukase, K, Nunez, G, Inohara, N

EMBO J 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created