Reactome | IFNG [extracellular region]

IFNG [extracellular region]

Stable Identifier

R-HSA-629621

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interferon gamma, IFNG_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:P15260 IFNGR1

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of IFNG gene (Homo sapiens)
        
        IFNG [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01579 IFNG

Gene Names

IFNG

Chain

signal peptide:1-23, chain:24-161, propeptide:162-166

Reference Genes

BioGPS Gene:3458 IFNG

COSMIC (genes):IFNG IFNG

CTD Gene:3458 IFNG

dbSNP Gene:3458 IFNG

ENSEMBL:ENSG00000111537 IFNG

HGNC:5438 IFNG

KEGG:hsa:3458 IFNG

Monarch:3458 IFNG

NCBI Gene:3458 IFNG

OMIM:147570 IFNG

UCSC:P01579 IFNG

Reference Transcript

RefSeq:NM_000619.3 IFNG

Other Identifiers

1021_at

11730947_at

1611_s_at

16767247

210354_PM_at

210354_at

3458

3461106

3461107

3461108

3461109

3461110

3461111

40702_at

7964787

A_23_P151294

GE80359

GO:0000122

GO:0001774

GO:0001819

GO:0002250

GO:0002281

GO:0002376

GO:0002726

GO:0005125

GO:0005133

GO:0005515

GO:0005576

GO:0005615

GO:0006355

GO:0006915

GO:0006954

GO:0006955

GO:0006959

GO:0007166

GO:0007259

GO:0008284

GO:0009615

GO:0010508

GO:0010628

GO:0010629

GO:0010634

GO:0030154

GO:0030225

GO:0030857

GO:0031334

GO:0032700

GO:0032722

GO:0032731

GO:0032735

GO:0032747

GO:0032755

GO:0032760

GO:0032834

GO:0033141

GO:0034393

GO:0038096

GO:0038110

GO:0038196

GO:0042307

GO:0042531

GO:0045348

GO:0045429

GO:0045672

GO:0045785

GO:0045821

GO:0045892

GO:0045944

GO:0048018

GO:0048143

GO:0048662

GO:0050729

GO:0050766

GO:0050769

GO:0050796

GO:0051044

GO:0051050

GO:0051607

GO:0060333

GO:0060552

GO:0060557

GO:0071902

GO:0090312

GO:0097191

GO:0097696

GO:0098542

GO:0098586

GO:0098772

GO:0150076

GO:1900222

GO:1900451

GO:1901857

GO:1902004

GO:1903078

GO:1903543

GO:1904440

GO:1904798

GO:2000309

HMNXSV003002949

ILMN_2207291

J00219_s_at

PH_hs_0000104

TC12001696.hg

TC12002948.hg

V00536_rna1_at

g186514_3p_at

Participates

as an output of

as a component of

IFNG dimer [extracellular region] (Homo sapiens)

Inferred To

ifng1 [extracellular region] (Danio rerio)

IFNG [extracellular region] (Bos taurus)

IFNG [extracellular region] (Canis familiaris)

IFNG [extracellular region] (Gallus gallus)

IFNG [extracellular region] (Sus scrofa)

Ifng [extracellular region] (Mus musculus)

Ifng [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_000610.2

ENSEMBL

ENST00000229135, ENSP00000229135, ENSG00000111537

OpenTargets

ENSG00000111537

ZINC - Substances

IFNG_HUMAN

ZINC target

P01579

PRO

P01579

GlyGen

P01579

PDB

1HIG, 6E3L, 1EKU, 6E3K, 3BES, 1FG9, 1FYH

GeneCards

IFNG

HPA

ENSG00000111537-IFNG

Pharos - Targets

P01579

Orphanet

IFNG

HMDB Protein

HMDBP02071

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15260 IFNGR1	2	IFNGR1 [plasma membrane] (R-HSA-629623) p-Y457-IFNGR1 [plasma membrane] (R-HSA-873798)	0.875	8
UniProt:Q66793 Q66793			0.558	2