SOS1 [cytosol]

Stable Identifier
R-HSA-64847
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Son of sevenless protein homolog 1, SOS-1
Icon
SOS1 [cytosol] icon
SOS1 [cytosol] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q07889 SOS1
Gene Names
SOS1
Chain
chain:1-1333
Reference Genes
BioGPS Gene:6654 SOS1
COSMIC (genes):SOS1 SOS1
CTD Gene:6654 SOS1
dbSNP Gene:6654 SOS1
ENSEMBL:ENSG00000115904 SOS1
HGNC:11187 SOS1
KEGG:hsa:6654 SOS1
Monarch:6654 SOS1
NCBI Gene:6654 SOS1
OMIM:182530 SOS1
UCSC:Q07889 SOS1
Reference Transcript
Other Identifiers
11720892_at
11720893_s_at
11720894_a_at
11720895_at
1557354_PM_at
1557354_at
16896710
16896744
212777_PM_at
212777_at
212780_PM_at
212780_at
227426_PM_at
227426_at
229261_PM_at
229261_at
230337_PM_at
230337_at
242682_PM_at
242682_at
2548965
2548968
2549093
2549094
2549095
2549096
2549097
2549098
2549099
2549100
2549101
2549102
2549103
2549104
2549105
2549106
2549107
2549108
2549109
2549110
2549111
2549112
2549113
2549114
2549115
2549116
2549117
2549118
2549119
2549120
2549121
2549122
2549123
2549124
2549125
2549126
2549128
2549129
2549130
2549131
2549132
2549133
2549134
2549147
2549148
2549149
2549150
2549156
2549157
2549158
2549159
2549160
2549161
2549163
2549165
2549191
2549215
303_at
33260_at
46678_at
50604_at
58423_at
58618_at
60439_at
6654
69184_at
79958_at
8051670
85839_at
ADDON000664.hg
ADDON001298.hg
A_21_P0014472
A_23_P343808
A_33_P3356406
GE57636
GE662247
GO:0000786
GO:0001782
GO:0001942
GO:0002260
GO:0002376
GO:0002931
GO:0003007
GO:0003209
GO:0003344
GO:0003677
GO:0005085
GO:0005096
GO:0005154
GO:0005198
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006357
GO:0007165
GO:0007173
GO:0007264
GO:0007265
GO:0007296
GO:0007411
GO:0008286
GO:0008543
GO:0014044
GO:0014069
GO:0017124
GO:0019221
GO:0019901
GO:0030527
GO:0033081
GO:0035264
GO:0038095
GO:0042110
GO:0042127
GO:0042129
GO:0042552
GO:0043025
GO:0043226
GO:0045742
GO:0046982
GO:0048009
GO:0048011
GO:0048514
GO:0048856
GO:0048870
GO:0050853
GO:0050900
GO:0051057
GO:0060021
GO:0060090
GO:0061029
GO:0061384
GO:0098772
GO:0098978
GO:0140693
GO:1904693
GO:1905360
GO:2000973
HMNXSV003037440
HMNXSV003049615
HMNXSV003051569
Hs.285655.0.A1_3p_at
Hs.285655.1.A1_3p_at
Hs.293345.0.S1_3p_at
Hs.326392.1.A1_3p_at
Hs.326392.1.A2_3p_at
Hs.7312.0.A1_3p_at
Hs2.175444.1.A1_3p_at
ILMN_1767135
PH_hs_0016186
PH_hs_0032906
PH_hs_0037192
TC02001761.hg
TC02001762.hg
p9093
p9094
Participates
as a component of
as an input of
as a member of
as a candidate of
Other forms of this molecule
SOS1 [plasma membrane]
p-4S-SOS1 [cytosol]
Inferred To
SOS1 [cytosol] (Bos taurus)
SOS1 [cytosol] (Canis familiaris)
SOS1 [cytosol] (Gallus gallus)
SOS1 [cytosol] (Sus scrofa)
gefW [cytosol] (Dictyostelium discoideum)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Xenopus tropicalis)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Rattus norvegicus)
sos-1 [cytosol] (Caenorhabditis elegans)
gefP [cytosol] (Dictyostelium discoideum)
Sos [cytosol] (Drosophila melanogaster)
Homologues of SOS1 [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - Substances
ZINC target
PRO
GlyGen
PDB
HPA
Pharos - Targets
Orphanet
HMDB Protein
Interactors (19)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.972 29
 UniProt:P01112 HRAS  20 0.938 11
 UniProt:P46108 CRK  1 0.792 6
 UniProt:Q15811 ITSN1  1 0.722 8
 UniProt:P08631 HCK  2 0.692 4
 UniProt:P16333 NCK1  2 0.688 6
 UniProt:P00533 EGFR  20 0.669 3
 UniProt:P19174 PLCG1  6 0.667 3
 UniProt:P20929 NEB  1 0.618 3
 UniProt:Q5TCZ1-2      0.611 5
 UniProt:Q9UNS2 COPS3  2 0.581 3
 UniProt:P29353 SHC1  5 0.564 2
 UniProt:P57075-2 UBASH3A      0.556 3
 UniProt:O60239 3BP5      0.553 2
 UniProt:Q8IZP0 ABI1  2 0.544 2
 UniProt:P27986 PIK3R1  16 0.536 3
 UniProt:Q9UKS6 PACSIN3  1 0.524 2
 UniProt:Q9Y5X1 SNX9  3 0.524 2
 UniProt:P46109 CRKL  2 0.483 3
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