Reactome | SSRP1 [nucleoplasm]

SSRP1 [nucleoplasm]

Stable Identifier

R-HSA-65105

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

FACT 80 kDa subunit, Structure-specific recognition protein 1 (SSRP1) (Recombination signal sequence recognition protein) (T160) (Chromatin-specific transcription elongation factor 80 KDA subunit, Structure-specific recognition protein 1, Recombination signal sequence recognition protein, T160, Chromatin-specific transcription elongation factor 80 kDa subunit

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08945 SSRP1

Gene Names

SSRP1, FACT80

Chain

initiator methionine:, chain:2-709

Reference Genes

BioGPS Gene:6749 SSRP1

COSMIC (genes):SSRP1 SSRP1

CTD Gene:6749 SSRP1

dbSNP Gene:6749 SSRP1

ENSEMBL:ENSG00000149136 SSRP1

HGNC:11327 SSRP1

KEGG:hsa:6749 SSRP1

Monarch:6749 SSRP1

NCBI Gene:6749 SSRP1

OMIM:604328 SSRP1

UCSC:Q08945 SSRP1

Reference Transcript

RefSeq:NM_003146.2 SSRP1

Other Identifiers

11715748_at

11715749_s_at

11715750_at

16738429

200956_PM_s_at

200956_s_at

200957_PM_s_at

200957_s_at

3373723

3373727

3373728

3373729

3373730

3373731

3373732

3373733

3373734

3373735

3373736

3373738

3373739

3373740

3373741

3373742

3373743

3373744

3373745

3373746

3373747

3373748

3373749

3373750

3373751

3373752

3373753

3373754

3373755

3373756

3373757

3373758

3373759

3373760

3373761

3373762

3373763

3373764

3373765

3373766

3373767

3373768

3373769

37739_at

6749

7948192

7948211

A_23_P36076

GE58118

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006260

GO:0006281

GO:0006325

GO:0006334

GO:0006337

GO:0031491

GO:0035101

GO:0042393

GO:0043226

GO:0065003

GO:1902275

HMNXSV003041638

Hs.79162.0.S1_3p_a_at

ILMN_2233099

M86737_at

PH_hs_0004576

TC11001788.hg

TC11001789.hg

g4507240_3p_a_at

Participates

as an input of

Formation of FACT complex (Homo sapiens)

as a component of

FACT complex [nucleoplasm] (Homo sapiens)

Inferred To

hmg-4 [nucleoplasm] (Caenorhabditis elegans)

Ssrp [nucleoplasm] (Drosophila melanogaster)

Ssrp1 [nucleoplasm] (Mus musculus)

Ssrp1 [nucleoplasm] (Rattus norvegicus)

POB3 [nucleoplasm] (Saccharomyces cerevisiae)

SSRP1 [nucleoplasm] (Bos taurus)

SSRP1 [nucleoplasm] (Canis familiaris)

SSRP1 [nucleoplasm] (Gallus gallus)

SSRP1 [nucleoplasm] (Plasmodium falciparum)

SSRP1 [nucleoplasm] (Sus scrofa)

ssrp1 [nucleoplasm] (Dictyostelium discoideum)

ssrp1 [nucleoplasm] (Xenopus tropicalis)

pob3 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of SSRP1 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_003137.1

ENSEMBL

ENST00000278412, ENSP00000278412

OpenTargets

ENSG00000149136

HPA

ENSG00000149136-SSRP1

PRO

Q08945

Pharos - Targets

Q08945

GlyGen

Q08945

PDB

4IFS, 5UMR, 6UPL, 6L1E, 6L1R, 6UPK, 6L34, 5UMS, 5VWE

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.905	11
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.816	8
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.802	6
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.759	4
UniProt:Q96HA7 TONSL			0.725	4
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.669	3
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.669	4
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.643	5
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.643	3
UniProt:Q6ZRQ5 MMS22			0.643	3
UniProt:Q9P0M6 H2AW			0.643	3
UniProt:Q86UY6 NAA40			0.643	3
UniProt:Q01831 XPC	5	monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub-XPC [nucleoplasm] (R-HSA-6782944) XPC [nucleoplasm] (R-HSA-67441)	0.643	4
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.615	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.564	4
UniProt:Q16778 H2BC21	9	HIST2H2BE [nucleoplasm] (R-HSA-181908) Ub-121-HIST2H2BE [nucleoplasm] (R-HSA-3364018) AcK16-HIST2H2BE [nucleoplasm] (R-HSA-4568660) AcK6-HIST2H2BE [nucleoplasm] (R-HSA-4568679) AcK21-HIST2H2BE [nucleoplasm] (R-HSA-4568716) AcK13-HIST2H2BE [nucleoplasm] (R-HSA-4568651) HIST2H2BE [extracellular region] (R-HSA-977571) Ack-HIST2H2BE [nucleoplasm] (R-HSA-4549257) Ub-HIST2H2BE [nucleoplasm] (R-HSA-6782539)	0.564	3
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.527	2
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	2
UniProt:Q7KZ85 SUPT6H	1	SUPT6H [nucleoplasm] (R-HSA-8932908)	0.527	2
UniProt:P06746 POLB	2	POLB [nucleoplasm] (R-HSA-53845) PolyUb-POLB [nucleoplasm] (R-HSA-6783152)	0.527	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.527	3
UniProt:Q9UNS1 TIMELESS	1	TIMELESS [nucleoplasm] (R-HSA-5684982)	0.527	2
UniProt:Q16777 H2AC20	13	HIST2H2AC [nucleoplasm] (R-HSA-181892) AcK-HIST2H2AC [nucleoplasm] (R-HSA-4551338) HIST2H2AC [extracellular region] (R-HSA-977563) MeR12-HIST2H2AC [nucleoplasm] (R-HSA-5229227) Me2aR12-HIST2H2AC [nucleoplasm] (R-HSA-5229306) Me2sR4-HIST2H2AC [nucleoplasm] (R-HSA-5218305) MeR4-HIST2H2AC [nucleoplasm] (R-HSA-5244625) Me2aR4-HIST2H2AC [nucleoplasm] (R-HSA-5244589) MeR30-HIST2H2AC [nucleoplasm] (R-HSA-5244542) Me2aR30-HIST2H2AC [nucleoplasm] (R-HSA-5244562) AcK6-HIST2H2AC [nucleoplasm] (R-HSA-4568572) Ub-HIST2H2AC [nucleoplasm] (R-HSA-6782532) K63polyUb-HIST2H2AC [nucleoplasm] (R-HSA-6783299)	0.527	2
UniProt:P0C0S5 H2AZ1	1	H2AFZ [extracellular region] (R-HSA-977575)	0.527	2
UniProt:P0C0S8 H2AC11	11	Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311) HIST1H2AG [nucleoplasm] (R-HSA-212084) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237)	0.527	3
UniProt:P12956 XRCC6	5	XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300)	0.527	2
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.527	3
UniProt:Q8IW19 APLF			0.527	2
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.527	2
UniProt:Q8N257 H2BC26	9	Ub-HIST3H2BB [nucleoplasm] (R-HSA-6782555) AcK-HIST3H2BB [nucleoplasm] (R-HSA-4549249) HIST3H2BB [extracellular region] (R-HSA-977572) AcK21-HIST3H2BB [nucleoplasm] (R-HSA-4568683) AcK13-HIST3H2BB [nucleoplasm] (R-HSA-4568654) AcK16-HIST3H2BB [nucleoplasm] (R-HSA-4568685) AcK6-HIST3H2BB [nucleoplasm] (R-HSA-4568677) Ub-121-HIST3H2BB [nucleoplasm] (R-HSA-3364030) HIST3H2BB [nucleoplasm] (R-HSA-181923)	0.527	3
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	4
UniProt:Q9BQ69 MACD1			0.527	2
UniProt:P24928 POLR2A	7	POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543)	0.527	2
UniProt:Q8IUE6 H2AC21	11	K63polyUb-HIST2H2AB [nucleoplasm] (R-HSA-6783295) Ub-HIST2H2AB [nucleoplasm] (R-HSA-6782490) AcK6-HIST2H2AB [nucleoplasm] (R-HSA-4568609) Me2aR30-HIST2H2AB [nucleoplasm] (R-HSA-5244567) MeR30-HIST2H2AB [nucleoplasm] (R-HSA-5244540) Me2aR4-HIST2H2AB [nucleoplasm] (R-HSA-5244588) MeR4-HIST2H2AB [nucleoplasm] (R-HSA-5244632) Me2aR12-HIST2H2AB [nucleoplasm] (R-HSA-5229314) MeR12-HIST2H2AB [nucleoplasm] (R-HSA-5229207) HIST2H2AB [nucleoplasm] (R-HSA-4549212) AcK-HIST2H2AB [nucleoplasm] (R-HSA-4551335)	0.527	2
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.512	4
UniProt:Q9UGP5 POLL	1	POLL [nucleoplasm] (R-HSA-5687352)	0.508	2
UniProt:Q96T37 RBM15			0.483	2

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