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GTF2B [nucleoplasm]
Stable Identifier
R-HSA-65888
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TFIIB, Transcription initiation factor IIB (General transcription factor TFIIB) (S300-II), Transcription initiation factor IIB, General transcription factor TFIIB, S300-II
Locations in the PathwayBrowser for interactor UniProt:P05067
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Transcription of the HIV genome (Homo sapiens)
HIV Transcription Initiation (Homo sapiens)
Abortive HIV-1 initiation after formation of the first phosphodiester bond (Homo sapiens)
GTF2B [nucleoplasm] (Homo sapiens)
RNA Polymerase II HIV Promoter Escape (Homo sapiens)
Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)
GTF2B [nucleoplasm] (Homo sapiens)
Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)
GTF2B [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Abortive Initiation Before Second Transition (Homo sapiens)
GTF2B [nucleoplasm] (Homo sapiens)
Abortive initiation after formation of the first phosphodiester bond (Homo sapiens)
GTF2B [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Homo sapiens)
RNA Polymerase II Promoter Escape (Homo sapiens)
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)
GTF2B [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (Homo sapiens)
Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Homo sapiens)
GTF2B [nucleoplasm] (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
GTF2B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00403 GTF2B
Gene Names
GTF2B, TF2B, TFIIB
Chain
chain:1-316
Reference Genes
BioGPS Gene:2959 GTF2B
COSMIC (genes):GTF2B GTF2B
CTD Gene:2959 GTF2B
dbSNP Gene:2959 GTF2B
ENSEMBL:ENSG00000137947 GTF2B
ENSEMBL_homo_sapiens_GENE:ENSG00000137947.12 GTF2B
HGNC:4648 GTF2B
KEGG Gene (Homo sapiens):2959 GTF2B
Monarch:2959 GTF2B
NCBI Gene:2959 GTF2B
OMIM:189963 GTF2B
UCSC:Q00403 GTF2B
Reference Transcript
RefSeq:NM_001514.5 GTF2B
Other Identifiers
1070_at
11716986_a_at
16689275
208066_PM_s_at
208066_s_at
2421754
2421755
2421756
2421759
2421760
2421761
2421763
2421764
2421773
2421776
2959
37380_at
37381_g_at
7917472
A_23_P34628
GE59841
GO:0000776
GO:0000793
GO:0000979
GO:0000993
GO:0001174
GO:0003677
GO:0003824
GO:0004402
GO:0005515
GO:0005634
GO:0005654
GO:0005669
GO:0005694
GO:0006325
GO:0006338
GO:0006351
GO:0006352
GO:0006366
GO:0006367
GO:0006473
GO:0007010
GO:0007059
GO:0008270
GO:0010467
GO:0016251
GO:0016407
GO:0016604
GO:0016740
GO:0016746
GO:0017025
GO:0019083
GO:0022414
GO:0032153
GO:0032993
GO:0036211
GO:0042585
GO:0043226
GO:0046872
GO:0046966
GO:0051123
GO:0051177
GO:0051225
GO:0051276
GO:0061733
GO:0065003
GO:0070897
GO:0090575
GO:0097550
GO:0140013
GO:0140096
GO:0140223
GO:0140297
GO:1904798
GO:1990114
GO:1990841
HMNXSV003035850
ILMN_1737857
M76766_at
PH_hs_0013567
PH_hs_0032359
TC01002843.hg
g13435384_3p_s_at
Participates
as an input of
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Homo sapiens)
as a component of
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
Pol II Promoter Escape Complex [nucleoplasm] (Homo sapiens)
HIV-1 Promoter Escape Complex [nucleoplasm] (Homo sapiens)
HIV-1 promoter:TFIID:TFIIA:TFIIB complex [nucleoplasm] (Homo sapiens)
HIV-1 open pre-initiation complex [nucleoplasm] (Homo sapiens)
HIV-1 initiation complex [nucleoplasm] (Homo sapiens)
HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Homo sapiens)
HIV-1 transcription complex [nucleoplasm] (Homo sapiens)
HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm] (Homo sapiens)
pol II promoter:TFIID:TFIIA:TFIIB complex [nucleoplasm] (Homo sapiens)
pol II open pre-initiation complex [nucleoplasm] (Homo sapiens)
Pol II initiation complex [nucleoplasm] (Homo sapiens)
Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Homo sapiens)
pol II transcription complex [nucleoplasm] (Homo sapiens)
pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Homo sapiens)
as an output of
Abortive initiation after formation of the first phosphodiester bond (Homo sapiens)
Abortive HIV-1 initiation after formation of the first phosphodiester bond (Homo sapiens)
Abortive Initiation Before Second Transition (Homo sapiens)
Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)
Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)
Inferred To
gtf2b [nucleoplasm]
(Xenopus tropicalis)
GTF2B [nucleoplasm]
(Bos taurus)
GTF2B [nucleoplasm]
(Caenorhabditis elegans)
GTF2B [nucleoplasm]
(Canis familiaris)
GTF2B [nucleoplasm]
(Dictyostelium discoideum)
GTF2B [nucleoplasm]
(Drosophila melanogaster)
GTF2B [nucleoplasm]
(Gallus gallus)
GTF2B [nucleoplasm]
(Mus musculus)
GTF2B [nucleoplasm]
(Rattus norvegicus)
GTF2B [nucleoplasm]
(Saccharomyces cerevisiae)
GTF2B [nucleoplasm]
(Schizosaccharomyces pombe)
GTF2B [nucleoplasm]
(Sus scrofa)
wu:fc44c11 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_001505.1
OpenTargets
ENSG00000137947
GeneCards
Q00403
HPA
ENSG00000137947-GTF2B
Ensembl
ENST00000370500
,
ENSG00000137947
,
ENSP00000359531
PRO
Q00403
Pharos - Targets
Q00403
PDB
7NVZ
,
7ENA
,
7ZX8
,
5IY8
,
8BYQ
,
8BZ1
,
7NVY
,
7NW0
,
7EG8
,
7ZX7
,
6O9L
,
1DL6
,
7EG7
,
7EDX
,
5IY7
,
7NVU
,
7NVT
,
5IY6
,
7LBM
,
7NVS
,
1TFB
,
7NVR
,
1C9B
,
1RLY
,
7ZWD
,
5IYD
,
7ZWC
,
7EGC
,
1RO4
,
7EGB
,
1VOL
,
5IYC
,
2PHG
,
8BVW
,
5IYB
,
7EGA
,
8GXQ
,
5WH1
,
7ZXE
,
7ENC
,
5IYA
,
8GXS
,
5IY9
,
7EG9
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.781
7
UniProt:Q14919 DRAP1
1
DRAP1 [nucleoplasm]
(R-HSA-1226029)
0.718
6
UniProt:P03122 VE2
0.683
3
UniProt:P03120 VE2
0.667
3
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.655
5
UniProt:P20226 TBP
1
TBP [nucleoplasm]
(R-HSA-83718)
0.589
2
UniProt:P62701 RPS4X
2
RPS4X [nucleoplasm]
(R-HSA-6798713)
RPS4X [cytosol]
(R-HSA-72375)
0.556
3
UniProt:Q96MN9-2 Q96MN92
0.556
3
UniProt:Q5T6S3 PHF19
1
PHF19 [nucleoplasm]
(R-HSA-5084115)
0.556
3
UniProt:O15381-5 O153815
0.556
3
UniProt:O43615 TIMM44
1
TIMM44(?-452) [mitochondrial inner membrane]
(R-HSA-1252038)
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.556
3
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:Q96D59 RN183
0.556
3
UniProt:Q8NBB4-2 ZSCAN1
0.556
3
UniProt:P13928 ANXA8
0.556
3
UniProt:Q9H972-2 C14ORF93
0.556
3
UniProt:Q15049 MLC1
0.556
3
UniProt:Q8TCT7-2 SPPL2B
0.556
3
UniProt:Q92613 JADE3
1
PHF16 [nucleoplasm]
(R-HSA-3321851)
0.556
3
UniProt:Q17RN3 FA98C
0.556
3
UniProt:Q7Z2T5 TRM1L
0.556
3
UniProt:Q8NHS9 SPT22
0.556
3
UniProt:Q14693 LPIN1
3
p-S106-LPIN1 [nucleoplasm]
(R-HSA-4419936)
LPIN1 [nuclear envelope]
(R-HSA-4419927)
LPIN1 [endoplasmic reticulum membrane]
(R-HSA-549157)
0.556
3
UniProt:Q5TAQ9-2 Q5TAQ92
0.556
3
UniProt:P58304 VSX2
0.556
3
UniProt:Q9BYU1 PBX4
0.556
3
UniProt:Q9HCC6 HES4
0.556
3
UniProt:Q8TBE0 BAHD1
0.556
3
IntAct:EBI-25835277 CCSB
0.556
3
UniProt:Q9BVN2 RUSC1
0.556
3
IntAct:EBI-25831191 CCSB
0.556
3
UniProt:Q9BUL9 RPP25
1
RPP25 [nucleoplasm]
(R-HSA-5696782)
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:Q6XD76 ASCL4
0.556
3
UniProt:P10073 ZSC22
0.556
3
UniProt:P60896 SEM1
2
SEM1 [nucleoplasm]
(R-HSA-8866665)
SEM1 [cytosol]
(R-HSA-8866674)
0.556
3
UniProt:Q3KNS6-3 Q3KNS63
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O75446 SAP30
1
SAP30 [nucleoplasm]
(R-HSA-351693)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:O75604-3 USP2
0.556
3
UniProt:Q13123 IK
1
IK [nucleoplasm]
(R-HSA-9770239)
0.556
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.556
3
UniProt:Q14781-2 CBX2
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
UniProt:P10589 NR2F1
1
NR2F1 [nucleoplasm]
(R-HSA-376280)
0.544
3
UniProt:P87662 P87662
0.544
3
UniProt:P03070 LT
0.544
3
UniProt:P17473 ICP4
0.544
4
UniProt:P48281
2
polySUMO2-VDR [nucleoplasm]
(R-MMU-4546376)
VDR [nucleoplasm]
(R-MMU-375512)
0.508
2
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