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TRADD [cytosol]
Stable Identifier
R-HSA-66376
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TNFR1-associated DEATH domain protein, Tumor necrosis factor receptor type 1 associated DEATH domain protein, TNFRSF1A-associated via death domain
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK1 variant is not cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1 variant:FADD [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
Dimerization of procaspase-8 (Homo sapiens)
TNF-mediated dimerization of procaspase-8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
MAPKAPK2 phosphorylates RIPK1 at S320 (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
ULK1 phosphorylates RIPK1 at S357 (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 binds FADD (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15628 TRADD
Gene Names
TRADD
Chain
chain:1-312
Reference Genes
COSMIC (genes):TRADD TRADD
ENSEMBL:ENSG00000102871 TRADD
HGNC:12030 TRADD
UCSC:Q15628 TRADD
Other Identifiers
11725373_a_at
11760282_at
16827248
1729_PM_at
1729_at
205641_PM_s_at
205641_s_at
3695434
3695435
3695436
3695437
3695438
3695439
3695440
3695441
3695442
3695443
3695445
8001938
8717
A_23_P54649
GE57769
GO:0002947
GO:0005068
GO:0005164
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006355
GO:0006915
GO:0007165
GO:0007169
GO:0007249
GO:0008625
GO:0009898
GO:0012501
GO:0019900
GO:0030335
GO:0030674
GO:0031264
GO:0032991
GO:0033209
GO:0035591
GO:0036462
GO:0042802
GO:0043065
GO:0043123
GO:0043226
GO:0043235
GO:0044877
GO:0050729
GO:0051092
GO:0051798
GO:0060090
GO:0070513
GO:0071356
GO:0097191
HMNXSV003005841
ILMN_1765851
ILMN_1793831
ILMN_1806800
L41690_at
PH_hs_0005024
TC16001180.hg
g13378136_3p_s_at
Participates
as a component of
TRADD:TRAF2:RIPK1 variant:FADD [cytosol] (Homo sapiens)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TRAF2:TRADD:p-S320-RIPK1 [cytosol] (Homo sapiens)
TRAF2:TRADD:p-S357-RIPK1 [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
as an input of
TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
Inferred To
tradd [cytosol]
(Danio rerio)
tradd [cytosol]
(Xenopus tropicalis)
Tradd [cytosol]
(Rattus norvegicus)
TRADD [cytosol]
(Bos taurus)
TRADD [cytosol]
(Canis familiaris)
TRADD [cytosol]
(Gallus gallus)
TRADD [cytosol]
(Mus musculus)
TRADD [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000345057
,
ENSP00000341268
,
ENSP00000462591
,
ENST00000486556
OpenTargets
ENSG00000102871
HPA
ENSG00000102871-TRADD
PRO
Q15628
Pharos - Targets
Q15628
GlyGen
Q15628
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19438 TNFRSF1A
2
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
TNFRSF1A(30-45) [plasma membrane]
(R-HSA-5675738)
0.957
16
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.942
14
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.806
7
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.796
6
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.725
7
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.725
6
UniProt:B7UI21 NLEB1
0.681
7
UniProt:P03230 LMP1
0.641
4
UniProt:P05783 KRT18
1
KRT18 [cytosol]
(R-HSA-201582)
0.602
11
UniProt:Q13546 RIPK1
20
RIPK1 [cytosol]
(R-HSA-168651)
RIPK1 [endosome membrane]
(R-HSA-450326)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
RIPK1 [plasma membrane]
(R-HSA-937073)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
0.564
3
UniProt:Q8N163 CCAR2
2
DBC1 [nucleoplasm]
(R-HSA-3371479)
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
0.564
2
UniProt:P25118
1
TNFRSF1A(30-45) [plasma membrane]
(R-MMU-5675738)
0.547
2
UniProt:Q13114 TRAF3
4
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
TRAF3 [cytosol]
(R-HSA-914241)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 R118W [cytosol]
(R-HSA-5602321)
0.547
2
UniProt:O95861 BPNT1
1
BPNT1 [cytosol]
(R-HSA-176573)
0.527
2
UniProt:Q61160
1
Fadd [cytosol]
(R-MMU-54639)
0.508
2
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