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XAB2 [nucleoplasm]
Stable Identifier
R-HSA-67411
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
XPA-binding protein 2, HCNP protein, PP3898
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
XAB2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HCS7 XAB2
Gene Names
XAB2, HCNP, KIAA1177, SYF1, PP3898
Chain
chain:1-855
Reference Genes
BioGPS Gene:56949 XAB2
COSMIC (genes):XAB2 XAB2
CTD Gene:56949 XAB2
dbSNP Gene:56949 XAB2
ENSEMBL:ENSG00000076924 XAB2
ENSEMBL_homo_sapiens_GENE:ENSG00000076924.12 XAB2
HGNC:14089 XAB2
KEGG Gene (Homo sapiens):56949 XAB2
Monarch:56949 XAB2
NCBI Gene:56949 XAB2
OMIM:610850 XAB2
UCSC:Q9HCS7 XAB2
Reference Transcript
RefSeq:NM_020196.2 XAB2
Other Identifiers
11757909_a_at
16867948
218110_PM_at
218110_at
3848443
3848444
3848446
3848447
3848448
3848450
3848451
3848453
3848455
3848456
3848458
3848461
3848464
3848465
3848466
3848469
3848471
3848473
3848476
3848477
3848478
3848479
47620_at
56949
8033392
A_23_P142013
A_24_P2093
GE53813
GO:0000349
GO:0000398
GO:0000974
GO:0001824
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0006281
GO:0006283
GO:0006351
GO:0006396
GO:0006397
GO:0006974
GO:0008380
GO:0016020
GO:0016071
GO:0043226
GO:0043231
GO:0048856
GO:0065003
GO:0071007
GO:0071013
GO:0071014
HMNXSV003053797
ILMN_1771057
PH_hs_0001015
TC19001114.hg
g9910259_3p_at
Participates
as a component of
XAB2 complex [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
PRP19-CDC5L related complex [nucleoplasm] (Homo sapiens)
Inferred To
fand [nucleoplasm]
(Drosophila melanogaster)
syf-1 [nucleoplasm]
(Caenorhabditis elegans)
SYF1 [nucleoplasm]
(Saccharomyces cerevisiae)
Xab2 [nucleoplasm]
(Mus musculus)
Xab2 [nucleoplasm]
(Rattus norvegicus)
xab2 [nucleoplasm]
(Dictyostelium discoideum)
xab2 [nucleoplasm]
(Xenopus tropicalis)
LOC555321 [nucleoplasm]
(Danio rerio)
Ghost homologue of XAB2 [nucleoplasm]
(Gallus gallus)
XAB2 [nucleoplasm]
(Bos taurus)
XAB2 [nucleoplasm]
(Canis familiaris)
XAB2 [nucleoplasm]
(Plasmodium falciparum)
XAB2 [nucleoplasm]
(Sus scrofa)
cwf3 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_064581.2
OpenTargets
ENSG00000076924
HPA
ENSG00000076924-XAB2
GeneCards
Q9HCS7
Ensembl
ENSP00000351137
,
ENSG00000076924
,
ENST00000358368
PRO
Q9HCS7
Pharos - Targets
Q9HCS7
PDB
7W5B
,
6QDV
,
7A5P
,
5MQF
,
6FF7
,
7W59
,
5Z57
,
5XJC
,
7ABI
,
5YZG
,
5Z56
,
6ID1
,
7W5A
,
8CH6
,
8C6J
,
6ICZ
,
6ID0
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09661 SNRPA1
1
SNRPA1 [nucleoplasm]
(R-HSA-71958)
0.59
2
UniProt:Q9CSN1 Snw1
1
Snw1 [nucleoplasm]
(R-MMU-2065315)
0.564
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.508
2
UniProt:O60231 DHX16
1
DHX16 [nucleoplasm]
(R-HSA-8850837)
0.508
2
UniProt:Q13123 IK
1
IK [nucleoplasm]
(R-HSA-9770239)
0.508
2
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.508
2
UniProt:Q03468 ERCC6
2
Ub-ERCC6 [nucleoplasm]
(R-HSA-6781853)
ERCC6 [nucleoplasm]
(R-HSA-54429)
0.499
2
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