Reactome | XPC [nucleoplasm]

XPC [nucleoplasm]

Stable Identifier

R-HSA-67441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

XPC protein, DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C complementing protein) (P125), xeroderma pigmentosum, complementation group C, DNA-repair protein complementing XP-C cells, Xeroderma pigmentosum group C complementing protein, p125

Locations in the PathwayBrowser for interactor UniProt:P32780 GTF2H1

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SUMOylation of XPC with SUMO1 (Homo sapiens)
        
        XPC [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01831 XPC

Gene Names

XPC, XPCC

Chain

initiator methionine:, chain:2-940

Reference Genes

BioGPS Gene:7508 XPC

COSMIC (genes):XPC XPC

CTD Gene:7508 XPC

dbSNP Gene:7508 XPC

ENSEMBL:ENSG00000154767 XPC

ENSEMBL_homo_sapiens_GENE:ENSG00000154767.15 XPC

HGNC:12816 XPC

KEGG Gene (Homo sapiens):7508 XPC

Monarch:7508 XPC

NCBI Gene:7508 XPC

OMIM:613208 XPC

UCSC:Q01831 XPC

Reference Transcript

RefSeq:NM_004628.4 XPC

Other Identifiers

11728207_a_at

11740553_a_at

16951007

1873_at

209375_PM_at

209375_at

2663807

2663809

2663811

2663812

2663813

2663814

2663815

2663817

2663820

2663823

2663824

2663828

2663834

2663835

2663836

2663837

2663839

2663840

2663841

2663842

2663843

2663844

2663847

2663848

2663849

2663850

2663851

2663852

2663853

2663855

2663856

35647_at

7508

8085486

D21089_at

GE57108

GO:0000109

GO:0000111

GO:0000278

GO:0000404

GO:0000405

GO:0000720

GO:0000785

GO:0003677

GO:0003684

GO:0003697

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006281

GO:0006289

GO:0006298

GO:0006351

GO:0006355

GO:0006974

GO:0009410

GO:0010224

GO:0010996

GO:0023052

GO:0031573

GO:0043226

GO:0043231

GO:0044877

GO:0045893

GO:0061629

GO:0070914

GO:0071942

GO:0090734

GO:0140110

GO:0140299

GO:0140612

GO:1901990

HMNXSV003012819

HMNXSV003019064

ILMN_1790807

PH_hs_0000038

PH_hs_0030850

TC03001194.hg

TC03002817.hg

g475156_3p_at

Participates

as an input of

as a component of

XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-XPC [nucleoplasm]

Ub,SUMO-XPC [nucleoplasm]

Ub,SUMO,K63polyUb-XPC [nucleoplasm]

monoSUMO1-K655-XPC [nucleoplasm]

Inferred To

XPC [nucleoplasm] (Bos taurus)

XPC [nucleoplasm] (Canis familiaris)

XPC [nucleoplasm] (Gallus gallus)

XPC [nucleoplasm] (Plasmodium falciparum)

XPC [nucleoplasm] (Sus scrofa)

rad4 [nucleoplasm] (Dictyostelium discoideum)

xpc-1 [nucleoplasm] (Caenorhabditis elegans)

RAD34 [nucleoplasm] (Saccharomyces cerevisiae)

Xpc [nucleoplasm] (Drosophila melanogaster)

Xpc [nucleoplasm] (Mus musculus)

Xpc [nucleoplasm] (Rattus norvegicus)

rhp42 [nucleoplasm] (Schizosaccharomyces pombe)

xpc [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004619.3

OpenTargets

ENSG00000154767

GeneCards

Q01831

HPA

ENSG00000154767-XPC

Ensembl

ENST00000476581, ENSP00000424548, ENSP00000285021, ENST00000285021, ENSG00000154767

PRO

Q01831

Pharos - Targets

Q01831

Orphanet

15736

HMDB Protein

HMDBP12797

PDB

8EBW, 8EBS, 2OBH, 2GGM, 8EBY, 8EBU, 2RVB, 8EBT, 8EBV, 2A4J, 8EBX

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.901	14
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.869	14
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.725	5
UniProt:O15182 CETN3			0.725	8
UniProt:P13288 KR2			0.645	9
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.643	4
UniProt:Q9NRW3 APOBEC3C	1	APOBEC3C [nucleoplasm] (R-HSA-8874997)	0.643	3
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.643	4
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.643	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.643	6
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.59	3
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.59	3
UniProt:Q9R1K9	3	polySUMO2,3-CETN2 [nucleoplasm] (R-MMU-4570486) CETN2 [nucleoplasm] (R-MMU-4570490) CETN2 [cytosol] (R-MMU-380298)	0.564	2
UniProt:P67870 CSNK2B	5	CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [cytosol] (R-HSA-201693)	0.527	2
UniProt:Q9BQ69 MACD1			0.527	2
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	3
UniProt:Q13156 RPA4	1	RPA4 [nucleoplasm] (R-HSA-68566)	0.527	3
UniProt:Q86UY6 NAA40			0.527	2
UniProt:Q9BPZ2 SPI2B			0.527	2
UniProt:P58876 H2BC5	9	Ub-HIST1H2BD [nucleoplasm] (R-HSA-6782546) AcK-HIST1H2BD [nucleoplasm] (R-HSA-4549255) HIST1H2BD [extracellular region] (R-HSA-977561) AcK16-HIST1H2BD [nucleoplasm] (R-HSA-4568633) AcK6-HIST1H2BD [nucleoplasm] (R-HSA-4568642) AcK21-HIST1H2BD [nucleoplasm] (R-HSA-4568627) AcK13-HIST1H2BD [nucleoplasm] (R-HSA-4568645) Ub-121-HIST1H2BD [nucleoplasm] (R-HSA-3364025) HIST1H2BD [nucleoplasm] (R-HSA-181912)	0.527	3
UniProt:Q8IW19 APLF			0.527	2
UniProt:P0C0S8 H2AC11	11	K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) HIST1H2AG [nucleoplasm] (R-HSA-212084) Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311)	0.527	4
UniProt:Q9P0M6 H2AW			0.527	3
UniProt:O75367 H2AY			0.527	4
UniProt:P0C0S5 H2AZ1	1	H2AFZ [extracellular region] (R-HSA-977575)	0.527	4
UniProt:Q12798 CETN1	7	PolyUb-Misfolded CETN1 [late endosome lumen] (R-HSA-9659982) CETN1 [cilium] (R-HSA-9639700) Misfolded CETN1 [cilium] (R-HSA-9639714) Misfolded CETN1 [cytosol] (R-HSA-9640113) Ub-Misfolded CETN1 [cytosol] (R-HSA-9641110) PolyUb-Misfolded CETN1 [cytosol] (R-HSA-9641126) PolyUb-Misfolded CETN1 [lysosomal lumen] (R-HSA-9659990)	0.527	5
UniProt:P23527 H2BC17	9	Ub-HIST1H2BO [nucleoplasm] (R-HSA-6782549) AcK-HIST1H2BO [nucleoplasm] (R-HSA-4549268) HIST1H2BO [extracellular region] (R-HSA-977557) AcK13-HIST1H2BO [nucleoplasm] (R-HSA-4568712) AcK21-HIST1H2BO [nucleoplasm] (R-HSA-4568713) AcK16-HIST1H2BO [nucleoplasm] (R-HSA-4568681) AcK6-HIST1H2BO [nucleoplasm] (R-HSA-4568708) Ub-121-HIST1H2BO [nucleoplasm] (R-HSA-3364033) HIST1H2BO [nucleoplasm] (R-HSA-181910)	0.527	3
UniProt:P06746 POLB	2	PolyUb-POLB [nucleoplasm] (R-HSA-6783152) POLB [nucleoplasm] (R-HSA-53845)	0.527	2
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.527	3
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	3
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) SDC2 [Golgi lumen] (R-HSA-2054101) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643)	0.527	2
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.483	2

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