RNA Polymerase II Pre-transcription Events

Stable Identifier
R-HSA-674695
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

For initiation, Pol II assembles with the general transcription factors TFIIB, TFIID, TFIIE, TFIIF and TFIIH, which are collectively known as the general transcription factors, at promoter DNA to form the pre-initiation complex (PIC). Until the nascent transcript is about 15 nucleotides long, the early transcribing complex is functionally unstable. In the beginning, short RNAs are frequently released and Pol II has to restart transcription (abortive cycling). There is a decline in the level of abortive transcription when the RNA reaches a length of about four nucleotides, and this transition is termed escape commitment

Literature References
PubMed ID Title Journal Year
14969722 Structure and function of RNA polymerase II

Cramer, P

Adv. Protein Chem. 2004
Participants
Participant Of
Orthologous Events