Reactome | USP19 binds HIF1A,BIRC2,BIRC3

USP19 binds HIF1A,BIRC2,BIRC3

Stable Identifier

R-HSA-6781797

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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USP19 promotes the stability of BIRC2 (c-IAP1) and BIRC3 (c-IAP2) by preventing them from self-ubiquitinating (Mei et al. 2011). Similarly, USP19 promotes the stability of the hypoxia-inducible factor 1-alpha (HIF-1a), with a mechanism that is independent of its catalytic activity (Altun et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
21849505	The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2 Hahn, AA, Mei, Y, Yang, X, Hu, S	J. Biol. Chem.	2011
22128162	Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia Paschke, J, Altun, M, Hassink, G, Liu, H, Pereira, T, Velasco, K, Zhao, B, Lindsten, K	J. Biol. Chem.	2012