ERCC8 (CSA) binds stalled RNA Pol II

Stable Identifier
R-HSA-6781833
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cockayne syndrome protein A (ERCC8, also known as CSA) is recruited to a stalled RNA polymerase II complex (RNA Pol II) at a site of DNA damage in an ERCC6 (CSB) dependent manner (Fousteri et al. 2006). ERCC8 is part of an ubiquitin ligase complex that, in addition to ERCC8, also contains DDB1, CUL4 (CUL4A or CUL4B) and RBX1 (Groisman et al. 2003). The COP9 signalosome complex prevents the ubiquitin ligase activity of the ERCC8:DDB1:CUL4:RBX1 at the early steps after DNA damage induction (Groisman et al. 2003, Fischer et al. 2011).

Literature References
PubMed ID Title Journal Year
16916636 Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

Fousteri, M, Vermeulen, W, van Zeeland, AA, Mullenders, LH

Mol. Cell 2006
22118460 The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

Fischer, ES, Scrima, A, Böhm, K, Matsumoto, S, Lingaraju, GM, Faty, M, Yasuda, T, Cavadini, S, Wakasugi, M, Hanaoka, F, Iwai, S, Gut, H, Sugasawa, K, Thomä, NH

Cell 2011
12732143 The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

Groisman, R, Polanowska, J, Kuraoka, I, Sawada, J, Saijo, M, Drapkin, R, Kisselev, AF, Tanaka, K, Nakatani, Y

Cell 2003
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