ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II

Stable Identifier
R-HSA-6781867
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The ubiquitin ligase complex ERCC8:DDB1:CUL4:RBX1 may ubiquitinate ERCC6 (CSB) (Groisman et al. 2006) at the later steps of TC-NER and may also be required in the ubiquitination of the RNA Pol II subunit POLR2A in response to damage (Bregman et al. 1996, Lee et al. 2002). Ubiquitination mediated by ERCC8 (CSA) containing ubiquitin ligase complex plays an important role in progression and termination of transcription-coupled nucleotide excision repair (TC-NER), although the mechanistic details are largely unknown.

Literature References
PubMed ID Title Journal Year
11904382 Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro

Lee, KB, Wang, D, Lippard, SJ, Sharp, PA

Proc. Natl. Acad. Sci. U.S.A. 2002
16751180 CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome

Groisman, R, Kuraoka, I, Chevallier, O, Gaye, N, Magnaldo, T, Tanaka, K, Kisselev, AF, Harel-Bellan, A, Nakatani, Y

Genes Dev. 2006
8876179 UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells

Bregman, DB, Halaban, R, van Gool, AJ, Henning, KA, Friedberg, EC, Warren, SL

Proc. Natl. Acad. Sci. U.S.A. 1996
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Catalyst Activity
Title
ubiquitin protein ligase activity of Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
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Activity
Orthologous Events
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