Reactome | DERL1 [endoplasmic reticulum membrane]

DERL1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-6781898

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Derlin-1, DERL1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BUN8 DERL1

Gene Names

DERL1, DER1, UNQ243/PRO276

Chain

initiator methionine:1, chain:2-251

Reference Genes

BioGPS Gene:79139 DERL1

COSMIC (genes):DERL1 DERL1

CTD Gene:79139 DERL1

dbSNP Gene:79139 DERL1

ENSEMBL:ENSG00000136986.10 DERL1

HGNC:28454 DERL1

KEGG Gene (Homo sapiens):79139 DERL1

Monarch:79139 DERL1

NCBI Gene:79139 DERL1

OMIM:608813 DERL1

UCSC:Q9BUN8 DERL1

Reference Transcript

Other Identifiers

0005550170

11721635_a_at

11721636_a_at

11721637_s_at

17080693

218172_PM_s_at

218172_s_at

219402_PM_s_at

219402_s_at

222543_PM_at

222543_at

3151402

3151403

3151404

3151405

3151406

3151407

3151408

3151410

3151411

3151412

3151413

3151414

3151419

3151422

3151423

3151426

3151427

45326_at

79139

8152628

91552_at

A_23_P216043

A_24_P175347

GE79678

GE82428

GO:0000839

GO:0002020

GO:0003674

GO:0005047

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005769

GO:0005770

GO:0005783

GO:0005789

GO:0006886

GO:0006986

GO:0008150

GO:0010498

GO:0015031

GO:0016020

GO:0016021

GO:0019899

GO:0023052

GO:0030163

GO:0030176

GO:0030433

GO:0030968

GO:0030970

GO:0031398

GO:0031410

GO:0031625

GO:0031648

GO:0032092

GO:0032991

GO:0033554

GO:0034620

GO:0036211

GO:0036502

GO:0036503

GO:0036513

GO:0038023

GO:0042288

GO:0042802

GO:0043161

GO:0043226

GO:0044322

GO:0044877

GO:0045184

GO:0051117

GO:0051787

GO:0071712

GO:1990381

HMNXSV003001099

Hs.241576.0.S2_3p_at

Hs.323114.1.S1_3p_a_at

ILMN_1695726

ILMN_2209748

PH_hs_0012961

TC08001575.hg

g8924181_3p_a_at

Participates

as a component of

as a member of

DERLs [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Derl1 [endoplasmic reticulum membrane] (Mus musculus)

derl1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

cup-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

DERL1 [endoplasmic reticulum membrane] (Bos taurus)

DERL1 [endoplasmic reticulum membrane] (Canis familiaris)

DERL1 [endoplasmic reticulum membrane] (Danio rerio)

DERL1 [endoplasmic reticulum membrane] (Gallus gallus)

DERL1 [endoplasmic reticulum membrane] (Rattus norvegicus)

DERL1 [endoplasmic reticulum membrane] (Sus scrofa)

Der-1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001128143.1, NP_077271.1

OpenTargets

ENSG00000136986

HPA

ENSG00000136986-DERL1

GeneCards

Q9BUN8

Ensembl

ENST00000259512, ENSG00000136986, ENSP00000259512, ENSP00000384289, ENST00000405944

PRO

Q9BUN8

Pharos - Targets

Q9BUN8

PDB

5GLF, 7CZB

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q8IWU4 SLC30A8	1	SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582) PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509)	0.556	3
UniProt:Q8TB40 ABHD4	1	ABHD4 [endoplasmic reticulum membrane] (R-HSA-5694582)	0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.527	2
UniProt:Q8TCT9 HM13	1	HM13 [endoplasmic reticulum membrane] (R-HSA-9708544)	0.524	6
UniProt:P51572 BCAP31	6	BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333)	0.499	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.499	2