USP13 binds SIAH2

Stable Identifier
R-HSA-6781899
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP13 mediates stabilization of the E3-ligase SIAH2 independently of deubiquitinase activity by binding and impairing SIAH2 autoubiquitination (Scortegagna et al. 2011).

Literature References
PubMed ID Title Journal Year
21659512 USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains

Scortegagna, M, Subtil, T, Qi, J, Kim, H, Zhao, W, Gu, W, Kluger, H, Ronai, ZA

J. Biol. Chem. 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed