ZRANB1 binds APC

Stable Identifier
R-HSA-6781905
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ZRANB1 (Trabid) binds and cleaves K63-linked ubiquitin chains. It is required for efficient TCF-mediated transcription in cells with high Wnt pathway activity, including colorectal cancer cell lines. ZRANB1 can deubiquitinate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription (Tran et al. 2008).

Participants
Participant Of
Orthologous Events