ZRANB1 binds APC

Stable Identifier
R-HSA-6781905
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ZRANB1 (Trabid) binds and cleaves K63-linked ubiquitin chains. It is required for efficient TCF-mediated transcription in cells with high Wnt pathway activity, including colorectal cancer cell lines. ZRANB1 can deubiquitinate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription (Tran et al. 2008).

Literature References
PubMed ID Title Journal Year
18281465 Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

Tran, H, Hamada, F, Schwarz-Romond, T, Bienz, M

Genes Dev. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed