Reactome | PPIE [nucleoplasm]

PPIE [nucleoplasm]

Stable Identifier

R-HSA-6781959

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peptidyl-prolyl cis-trans isomerase E, Cyclophilin-33, CYP33, Rotamase E

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Dual incision in TC-NER (Homo sapiens)
      - 3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
      - ERCC5 and RPA bind TC-NER site (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
      - RNA Pol II backtracking in TC-NER (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
    - Formation of TC-NER Pre-Incision Complex (Homo sapiens)
      - Assembly of the pre-incision complex in TC-NER (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
      - UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
    - Recovery of RNA synthesis after TC-NER (Homo sapiens)
      - TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)
      - XAB2 complex [nucleoplasm] (Homo sapiens)
        
        PPIE [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UNP9 PPIE

Gene Names

PPIE, CYP33

Chain

chain:1-301

Reference Genes

BioGPS Gene:10450 PPIE

COSMIC (genes):PPIE PPIE

CTD Gene:10450 PPIE

dbSNP Gene:10450 PPIE

ENSEMBL:ENSG00000084072 PPIE

HGNC:9258 PPIE

KEGG Gene (Homo sapiens):10450 PPIE

Monarch:10450 PPIE

NCBI Gene:10450 PPIE

OMIM:602435 PPIE

UCSC:Q9UNP9 PPIE

Reference Transcript

Other Identifiers

0004610632

10450

11716896_a_at

11716897_x_at

11739533_a_at

11740033_a_at

11753960_x_at

16662908

19357

1ZMF

20131

202494_at

210502_s_at

2331616

2331619

2331620

2331624

2331625

2331626

2331627

2331630

2331633

2331635

2331636

2331637

2331638

2331645

2331647

2331648

2407904

2407921

2CQB

2KU7

2KYX

2R99

34364_at

34365_at

34366_g_at

3LPY

3MDF

3UCH

5MQF

5YZG

5Z56

5Z57

7900354

A_23_P74526

AAC00006

AAC00007

AAD19906

AAD19907

AAH04898

AAH08451

AAI07737

AAZ93379

AF042385

AF042386

AF104012

AF104013

AK313666

AL033527

AL035404

AL049824

BAG36418

BC004898

BC008451

BC107736

CCDS442

CCDS443

CCDS53299

CH471059

DQ160195

E9PEQ6

E9PIB0

E9PK21

E9PKY5

E9PMH0

EAX07255

ENSG00000084072

ENSP00000312769

ENSP00000348904

ENSP00000361918

ENST00000324379

ENST00000324379.9

ENST00000356511

ENST00000356511.6

ENST00000372830

ENST00000372830.5

EntrezGene:10450

EntrezGene:PPIE

g2828150_3p_a_at

g2828150_3p_x_at

g5174636_3p_at

GE54371

GO:0000398

GO:0000413

GO:0002376

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0003755

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006259

GO:0006283

GO:0006355

GO:0006397

GO:0006457

GO:0006464

GO:0006810

GO:0006950

GO:0008143

GO:0008150

GO:0008380

GO:0009058

GO:0016018

GO:0016192

GO:0016607

GO:0016853

GO:0031410

GO:0032991

GO:0034641

GO:0034774

GO:0042026

GO:0043226

GO:0043312

GO:0044403

GO:0045070

GO:0051082

GO:0071007

GO:0071013

GO:1904813

H0YCV4

HGNC:9258

HPA019357

HPA020131

ILMN_1654037

ILMN_1674825

ILMN_1680341

ILMN_2326737

ILMN_2348503

IPR000504

IPR002130

IPR012677

IPR016304

IPR020892

IPR029000

IPR034168

IPR035979

MIM:602435

NM_001195007

NM_001319293

NM_006112

NM_203456

NP_001181936

NP_001306222

NP_006103

NP_982281

NR_036543

PF00076

PF00160

PH_hs_0022035

PPIE

PPIE-201

PPIE-202

PPIE-203

PR00153

SM00360

TC01004332.hg

UPI000002A7A4

UPI0000128C84

UPI00002057ED

XM_006710289

XM_006710290

XM_017000051

XP_006710352

XP_006710353

XP_016855540

XR_946519

XR_946520

XR_946521

Participant Of

hasComponent

input

Formation of the Spliceosomal B Complex

Other forms of this molecule

PPIE [ficolin-1-rich granule lumen]

PPIE [extracellular region]

PPIE [secretory granule lumen]

Inferred To

PPIE [nucleoplasm] (Bos taurus)

PPIE [nucleoplasm] (Canis familiaris)

PPIE [nucleoplasm] (Danio rerio)

PPIE [nucleoplasm] (Dictyostelium discoideum)

PPIE [nucleoplasm] (Gallus gallus)

PPIE [nucleoplasm] (Mus musculus)

PPIE [nucleoplasm] (Plasmodium falciparum)

PPIE [nucleoplasm] (Rattus norvegicus)

PPIE [nucleoplasm] (Saccharomyces cerevisiae)

PPIE [nucleoplasm] (Schizosaccharomyces pombe)

PPIE [nucleoplasm] (Sus scrofa)

PPIE [nucleoplasm] (Xenopus tropicalis)

Homologues of PPIE [nucleoplasm] (Dictyostelium discoideum)

Homologues of PPIE [nucleoplasm] (Plasmodium falciparum)

Homologues of PPIE [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of PPIE [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of PPIE [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_006103.1, NP_982281.1, NP_001181936.1, XP_016855540.1

OpenTargets

ENSG00000084072

GeneCards

Q9UNP9

PRO

Q9UNP9

PDB

5Z57, 5MQF, 1ZMF, 3MDF, 3LPY, 6ID1, 2R99, 6ICZ, 3UCH, 2KYX, 6ID0, 5YZG, 2KU7, 2CQB, 5Z56, 6FF7

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.834	10
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.704	4
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.659	8
UniProt:Q9CSN1 Snw1	1	Snw1 [nucleoplasm] (R-MMU-2065315)	0.564	2
UniProt:P68431 HIST1H3A	59	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) HIST1H3A [extracellular region] (R-HSA-977570) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) AcK15-HIST1H3A [nucleoplasm] (R-HSA-4568743) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5229050) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4754188) Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4754169) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791) Me3K80-HIST1H3A [nucleoplasm] (R-HSA-5649795) Me2K80-HIST1H3A [nucleoplasm] (R-HSA-5649768) Me3K37-HIST1H3A [nucleoplasm] (R-HSA-5638160) Me2K37-HIST1H3A [nucleoplasm] (R-HSA-4722125) MeK10-HIST1H3A [nucleoplasm] (R-HSA-212105) MeK28-HIST1H3A [nucleoplasm] (R-HSA-5638327) MeK-10-HIST1H3A [cytosol] (R-HSA-8943830) HIST1H3A [cytosol] (R-HSA-8943829) Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-5244526) MeK5-HIST1H3A [nucleoplasm] (R-HSA-4687016) Cit27-HIST1H3A [nucleoplasm] (R-HSA-5246532) Cit3-HIST1H3A [nucleoplasm] (R-HSA-5246544) Cit9-HIST1H3A [nucleoplasm] (R-HSA-5246530) Cit18-HIST1H3A [nucleoplasm] (R-HSA-5246534) MeR18-HIST1H3A [nucleoplasm] (R-HSA-5229059) MeR3-HIST1H3A [nucleoplasm] (R-HSA-5244529) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5244801) MeR9-HIST1H3A [nucleoplasm] (R-HSA-5244806) Me2K5,Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-8936572) Ack10-HIST1H3A [nucleoplasm] (R-HSA-4568939) p-T12-HIST1H3A [nucleoplasm] (R-HSA-5625872) p-T12,MeK-10-HIST1H3A [nucleoplasm] (R-HSA-5625859) p-T12, Me2K-10-HIST1H3A [nucleoplasm] (R-HSA-5625790) Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-427734) p-T12, Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-5625757) Me2K10-HIST1H3A [nucleoplasm] (R-HSA-427378) Me3K5-HIST1H3A [nucleoplasm] (R-HSA-1214186) HIST1H3A [nucleoplasm] (R-HSA-212070) Me3K-28-HIST1H3A [nucleoplasm] (R-HSA-212220) Me2K5-HIST1H3A [nucleoplasm] (R-HSA-1214170)	0.544	3
UniProt:Q96D03 DDT4L			0.488	2
UniProt:Q83D60 Q83D60			0.488	2