Reactome | PPIE [nucleoplasm]

PPIE [nucleoplasm]

Stable Identifier

R-HSA-6781959

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peptidyl-prolyl cis-trans isomerase E, Cyclophilin-33, CYP33, Rotamase E

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UNP9 PPIE

Gene Names

PPIE, CYP33

Chain

chain:1-301

Reference Genes

BioGPS Gene:10450 PPIE

COSMIC (genes):PPIE PPIE

CTD Gene:10450 PPIE

dbSNP Gene:10450 PPIE

ENSEMBL:ENSG00000084072 PPIE

HGNC:9258 PPIE

KEGG Gene (Homo sapiens):10450 PPIE

Monarch:10450 PPIE

NCBI Gene:10450 PPIE

OMIM:602435 PPIE

UCSC:Q9UNP9 PPIE

Reference Transcript

Other Identifiers

0004610632

10450

11716896_a_at

11716897_x_at

11739533_a_at

11740033_a_at

11753960_x_at

16662908

202494_at

210502_s_at

229375_at

2331616

2331619

2331620

2331624

2331625

2331626

2331627

2331630

2331633

2331635

2331636

2331637

2331638

2331639

2331640

2331645

2331647

2331648

2407904

2407921

34364_at

34365_at

34366_g_at

63583_at

7900354

A_14_P200019

A_24_P54083

GE54371

GO:0000398

GO:0000413

GO:0002376

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0003755

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006259

GO:0006283

GO:0006355

GO:0006397

GO:0006457

GO:0006464

GO:0006810

GO:0006950

GO:0008143

GO:0008150

GO:0008380

GO:0009058

GO:0016018

GO:0016192

GO:0016607

GO:0016853

GO:0031410

GO:0032991

GO:0034641

GO:0034774

GO:0043226

GO:0043312

GO:0044403

GO:0045070

GO:0071007

GO:0071013

GO:1904813

Hs.22516.0.A1_3p_at

ILMN_1654037

ILMN_1674825

ILMN_1680341

ILMN_2326737

PH_hs_0022035

TC01004332.hg

g2828150_3p_a_at

g2828150_3p_x_at

g5174636_3p_at

Participant Of

input

Formation of the Spliceosomal B Complex

hasComponent

Other forms of this molecule

PPIE [ficolin-1-rich granule lumen]

PPIE [extracellular region]

PPIE [secretory granule lumen]

Inferred To

cyn-1 [nucleoplasm] (Caenorhabditis elegans)

ppie [nucleoplasm] (Danio rerio)

ppie [nucleoplasm] (Xenopus tropicalis)

PPIE [nucleoplasm] (Canis familiaris)

PPIE [nucleoplasm] (Gallus gallus)

PPIE [nucleoplasm] (Sus scrofa)

ppiA [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of PPIE [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of PPIE [nucleoplasm] (Schizosaccharomyces pombe)

Ppie [nucleoplasm] (Mus musculus)

Ppie [nucleoplasm] (Rattus norvegicus)

cyp33 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001181936.1, NP_006103.1, NP_982281.1, XP_016855540.1

OpenTargets

ENSG00000084072

HPA

ENSG00000084072-PPIE

GeneCards

Q9UNP9

Ensembl

ENSG00000084072, ENSP00000348904, ENST00000372830, ENST00000324379, ENSP00000361918, ENSP00000312769, ENST00000356511

PRO

Q9UNP9

PDB

5Z57, 1ZMF, 6ICZ, 5MQF, 2KYX, 6FF7, 3LPY, 3UCH, 6ID0, 3MDF, 5Z56, 2CQB, 5YZG, 2R99, 2KU7, 6ID1

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.882	12
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.739	9
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.704	4
UniProt:Q9CSN1 Snw1	1	Snw1 [nucleoplasm] (R-MMU-2065315)	0.564	2
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3
UniProt:P06396 GSN	7	GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P68431 H3C1	59	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) HIST1H3A [extracellular region] (R-HSA-977570) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) AcK15-HIST1H3A [nucleoplasm] (R-HSA-4568743) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5229050) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4754188) Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4754169) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791) Me3K80-HIST1H3A [nucleoplasm] (R-HSA-5649795) Me2K80-HIST1H3A [nucleoplasm] (R-HSA-5649768) Me3K37-HIST1H3A [nucleoplasm] (R-HSA-5638160) Me2K37-HIST1H3A [nucleoplasm] (R-HSA-4722125) MeK10-HIST1H3A [nucleoplasm] (R-HSA-212105) MeK28-HIST1H3A [nucleoplasm] (R-HSA-5638327) MeK-10-HIST1H3A [cytosol] (R-HSA-8943830) HIST1H3A [cytosol] (R-HSA-8943829) Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-5244526) MeK5-HIST1H3A [nucleoplasm] (R-HSA-4687016) Cit27-HIST1H3A [nucleoplasm] (R-HSA-5246532) Cit3-HIST1H3A [nucleoplasm] (R-HSA-5246544) Cit9-HIST1H3A [nucleoplasm] (R-HSA-5246530) Cit18-HIST1H3A [nucleoplasm] (R-HSA-5246534) MeR18-HIST1H3A [nucleoplasm] (R-HSA-5229059) MeR3-HIST1H3A [nucleoplasm] (R-HSA-5244529) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5244801) MeR9-HIST1H3A [nucleoplasm] (R-HSA-5244806) Ack10-HIST1H3A [nucleoplasm] (R-HSA-4568939) Me2K10-HIST1H3A [nucleoplasm] (R-HSA-427378) Me2K5,Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-8936572) p-T12, Me2K-10-HIST1H3A [nucleoplasm] (R-HSA-5625790) p-T12-HIST1H3A [nucleoplasm] (R-HSA-5625872) p-T12,MeK-10-HIST1H3A [nucleoplasm] (R-HSA-5625859) p-T12, Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-5625757) Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-427734) Me3K5-HIST1H3A [nucleoplasm] (R-HSA-1214186) HIST1H3A [nucleoplasm] (R-HSA-212070) Me3K-28-HIST1H3A [nucleoplasm] (R-HSA-212220) Me2K5-HIST1H3A [nucleoplasm] (R-HSA-1214170)	0.544	3
UniProt:Q83D60 Q83D60			0.488	2

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