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ISY1 [nucleoplasm]
Stable Identifier
R-HSA-6781963
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Pre-mRNA-splicing factor ISY1 homolog, KIAA1160
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
XAB2 complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
intron-containing complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Formation of Exon Junction Complex (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Formation of an intermediate Spliceosomal C (Bact) complex (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B Complex (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Formation of the active Spliceosomal C (B*) complex (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
ISY1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULR0 ISY1
Gene Names
ISY1, KIAA1160
Chain
chain:1-285
Reference Genes
BioGPS Gene:100534599 ISY1
BioGPS Gene:57461 ISY1
COSMIC (genes):ISY1 ISY1
CTD Gene:100534599 ISY1
CTD Gene:57461 ISY1
dbSNP Gene:100534599 ISY1
dbSNP Gene:57461 ISY1
ENSEMBL:ENSG00000240682 ISY1
HGNC:29201 ISY1
KEGG Gene (Homo sapiens):100534599 ISY1
KEGG Gene (Homo sapiens):57461 ISY1
Monarch:100534599 ISY1
Monarch:57461 ISY1
NCBI Gene:100534599 ISY1
NCBI Gene:57461 ISY1
OMIM:612764 ISY1
UCSC:Q9ULR0 ISY1
Reference Transcript
RefSeq:NM_001204890.1 ISY1
RefSeq:NM_020701.3 ISY1
RefSeq:NM_001199469.1 ISY1
Other Identifiers
0002230411
11728208_a_at
11755136_x_at
16958931
223428_s_at
223429_x_at
223831_x_at
232142_at
2694616
2694618
2694619
2694620
2694621
2694622
2694623
2694624
2694625
2694627
2694630
2694631
2694632
2694634
2694635
2694636
2694637
2694639
57461
73432_at
8090533
90723_at
A_23_P124164
A_23_P155179
GE79663
GO:0000350
GO:0000389
GO:0000398
GO:0000974
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005681
GO:0006259
GO:0006283
GO:0006397
GO:0006950
GO:0008150
GO:0008380
GO:0022607
GO:0022618
GO:0032991
GO:0034641
GO:0043226
GO:0065003
GO:0071006
GO:0071013
GO:0071014
GO:0071020
Hs.279745.0.S1_3p_at
ILMN_1662128
ILMN_1664102
ILMN_1683369
ILMN_1781099
ILMN_1785857
PH_hs_0026797
PH_hs_0037558
TC03003394.hg
g13325245_3p_a_at
Participant Of
input
Formation of the Spliceosomal B Complex
hasComponent
intron-containing complex [nucleoplasm]
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm]
Spliceosomal Active C (B*) Complex [nucleoplasm]
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm]
Spliceosomal B Complex [nucleoplasm]
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]
XAB2 complex [nucleoplasm]
Inferred To
Ghost homologue of ISY1 [nucleoplasm] (Xenopus tropicalis)
ISY1 [nucleoplasm] (Canis familiaris)
ISY1 [nucleoplasm] (Gallus gallus)
ISY1 [nucleoplasm] (Saccharomyces cerevisiae)
ISY1 [nucleoplasm] (Sus scrofa)
cwf12 [nucleoplasm] (Schizosaccharomyces pombe)
Isy1 [nucleoplasm] (Mus musculus)
Isy1 [nucleoplasm] (Rattus norvegicus)
isy-1 [nucleoplasm] (Caenorhabditis elegans)
Dmel\CG9667 [nucleoplasm] (Drosophila melanogaster)
isy1 [nucleoplasm] (Danio rerio)
isy1 [nucleoplasm] (Dictyostelium discoideum)
Cross References
RefSeq
NP_001186398.1
,
NP_065752.1
,
NP_001191819.1
OpenTargets
ENSG00000240682
GeneCards
Q9ULR0
HPA
ENSG00000240682-ISY1
Ensembl
ENST00000273541
,
ENSG00000240682
,
ENST00000393295
,
ENSP00000376973
,
ENSP00000273541
PRO
Q9ULR0
PDB
5YZG
,
6FF7
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HCS7 XAB2
1
XAB2 [nucleoplasm]
(R-HSA-67411)
0.703
7
UniProt:O60306 AQR
1
AQR [nucleoplasm]
(R-HSA-6781960)
0.659
6
UniProt:Q9CSN1 Snw1
1
Snw1 [nucleoplasm]
(R-MMU-2065315)
0.564
2
UniProt:Q8N131 PORIM
0.556
3
UniProt:Q8N371-3 KDM8
0.556
5
UniProt:P40692 MLH1
3
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.556
3
UniProt:P36957 DLST
2
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
DLST [mitochondrial matrix]
(R-HSA-6792574)
0.556
3
UniProt:Q8IYI6 EXOC8
2
EXOC8 [cytosol]
(R-HSA-5623388)
EXOC8 [plasma membrane]
(R-HSA-264948)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:Q86YD7 F90A1
0.556
3
UniProt:P25800 LMO1
1
LMO1 [nucleoplasm]
(R-HSA-8956514)
0.556
3
UniProt:P27797 CALR
6
CALR [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
0.556
3
UniProt:Q8TDX7 NEK7
2
NEK7 [cytosol]
(R-HSA-2530599)
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:P25791-3 LMO2
0.556
3
UniProt:Q14562 DHX8
0.508
2
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