Reactome | ISY1 [nucleoplasm]

ISY1 [nucleoplasm]

Stable Identifier

R-HSA-6781963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA-splicing factor ISY1 homolog, KIAA1160

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Dual incision in TC-NER (Homo sapiens)
      - 3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
      - ERCC5 and RPA bind TC-NER site (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
      - RNA Pol II backtracking in TC-NER (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
    - Formation of TC-NER Pre-Incision Complex (Homo sapiens)
      - Assembly of the pre-incision complex in TC-NER (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
      - UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
    - Recovery of RNA synthesis after TC-NER (Homo sapiens)
      - TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)
      - XAB2 complex [nucleoplasm] (Homo sapiens)
        
        ISY1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9ULR0 ISY1

Gene Names

ISY1, KIAA1160

Chain

chain:1-285

Reference Genes

BioGPS Gene:100534599 ISY1

BioGPS Gene:57461 ISY1

COSMIC (genes):ISY1 ISY1

CTD Gene:100534599 ISY1

CTD Gene:57461 ISY1

dbSNP Gene:100534599 ISY1

dbSNP Gene:57461 ISY1

ENSEMBL:ENSG00000240682 ISY1

HGNC:29201 ISY1

KEGG Gene (Homo sapiens):100534599 ISY1

KEGG Gene (Homo sapiens):57461 ISY1

Monarch:100534599 ISY1

Monarch:57461 ISY1

NCBI Gene:100534599 ISY1

NCBI Gene:57461 ISY1

OMIM:612764 ISY1

UCSC:Q9ULR0 ISY1

Reference Transcript

Other Identifiers

0002230411

11728208_a_at

11755136_x_at

16958931

16995

223428_s_at

223429_x_at

223831_x_at

232142_at

2694616

2694618

2694619

2694620

2694621

2694622

2694623

2694624

2694625

2694627

2694630

2694631

2694632

2694634

2694635

2694636

2694637

2694639

57461

5YZG

6312

6FF7

73432_at

8090533

90723_at

A8MVI5

A_23_P124164

A_23_P155179

AAH04442

AAH07409

AAH19849

AB032986

BAA86474

BC004442

BC007409

BC019849

CCDS43149

CCDS56277

D6RC18

ENSG00000240682

ENSP00000273541

ENSP00000376973

ENST00000273541

ENST00000273541.12

ENST00000393295

ENST00000393295.7

EntrezGene:57461

EntrezGene:ISY1

g13325245_3p_a_at

GE79663

GO:0000350

GO:0000384

GO:0000389

GO:0000398

GO:0000974

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005681

GO:0006259

GO:0006283

GO:0006397

GO:0006950

GO:0008150

GO:0008380

GO:0022607

GO:0022618

GO:0032991

GO:0034641

GO:0043226

GO:0065003

GO:0071006

GO:0071013

GO:0071014

GO:0071020

H0YA89

HGNC:29201

HPA006312

HPA016995

Hs.279745.0.S1_3p_at

ILMN_1662128

ILMN_1664102

ILMN_1683369

ILMN_1781099

ILMN_1785857

IPR009360

IPR029012

IPR037200

ISY1

ISY1-201

ISY1-203

MIM:612764

NM_001199469

NM_020701

NP_001186398

NP_065752

PF06246

PH_hs_0026797

PH_hs_0037558

TC03003394.hg

UPI00000726C6

UPI0000073E8C

Participant Of

input

Formation of the Spliceosomal B Complex

hasComponent

Inferred To

ISY1 [nucleoplasm] (Bos taurus)

ISY1 [nucleoplasm] (Canis familiaris)

ISY1 [nucleoplasm] (Gallus gallus)

ISY1 [nucleoplasm] (Plasmodium falciparum)

ISY1 [nucleoplasm] (Saccharomyces cerevisiae)

ISY1 [nucleoplasm] (Sus scrofa)

cwf12 [nucleoplasm] (Schizosaccharomyces pombe)

Isy1 [nucleoplasm] (Mus musculus)

Isy1 [nucleoplasm] (Rattus norvegicus)

isy-1 [nucleoplasm] (Caenorhabditis elegans)

Dmel\CG9667 [nucleoplasm] (Drosophila melanogaster)

isy1 [nucleoplasm] (Danio rerio)

isy1 [nucleoplasm] (Dictyostelium discoideum)

isy1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001186398.1, NP_001191819.1, NP_065752.1

OpenTargets

ENSG00000240682

GeneCards

Q9ULR0

HPA

ENSG00000240682-ISY1

Ensembl

ENSP00000273541, ENST00000393295, ENSP00000376973, ENST00000273541, ENSG00000240682

PRO

Q9ULR0

PDB

6FF7, 5YZG

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.703	7
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.659	6
UniProt:Q9CSN1 Snw1	1	Snw1 [nucleoplasm] (R-MMU-2065315)	0.564	2
UniProt:P25791-3 LMO2			0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q8N371-3 KDM8			0.556	5
UniProt:P40692 MLH1	3	MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:Q8IYI6 EXOC8	2	EXOC8 [cytosol] (R-HSA-5623388) EXOC8 [plasma membrane] (R-HSA-264948)	0.556	3
UniProt:Q14562 DHX8			0.508	2

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