Reactome | ISY1 [nucleoplasm]

ISY1 [nucleoplasm]

Stable Identifier

R-HSA-6781963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA-splicing factor ISY1 homolog, KIAA1160

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9ULR0 ISY1

Gene Names

ISY1, KIAA1160

Chain

chain:1-285

Reference Genes

BioGPS Gene:100534599 ISY1

BioGPS Gene:57461 ISY1

COSMIC (genes):ISY1 ISY1

CTD Gene:100534599 ISY1

CTD Gene:57461 ISY1

dbSNP Gene:100534599 ISY1

dbSNP Gene:57461 ISY1

ENSEMBL:ENSG00000240682 ISY1

HGNC:29201 ISY1

KEGG Gene (Homo sapiens):100534599 ISY1

KEGG Gene (Homo sapiens):57461 ISY1

Monarch:100534599 ISY1

Monarch:57461 ISY1

NCBI Gene:100534599 ISY1

NCBI Gene:57461 ISY1

OMIM:612764 ISY1

UCSC:Q9ULR0 ISY1

Reference Transcript

Other Identifiers

0002230411

11728208_a_at

11755136_x_at

16958931

223428_s_at

223429_x_at

223831_x_at

232142_at

2694616

2694618

2694619

2694620

2694621

2694622

2694623

2694624

2694625

2694627

2694630

2694631

2694632

2694634

2694635

2694636

2694637

2694639

57461

73432_at

8090533

90723_at

A_23_P124164

A_23_P155179

GE79663

GO:0000350

GO:0000389

GO:0000398

GO:0000974

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0006259

GO:0006283

GO:0006397

GO:0006950

GO:0008150

GO:0008380

GO:0022607

GO:0022618

GO:0032991

GO:0034641

GO:0043226

GO:0065003

GO:0071006

GO:0071013

GO:0071014

GO:0071020

HMNXSV003039764

Hs.279745.0.S1_3p_at

ILMN_1662128

ILMN_1664102

ILMN_1683369

ILMN_1781099

ILMN_1785857

PH_hs_0026797

PH_hs_0037558

TC03003394.hg

g13325245_3p_a_at

Participates

as an input of

Formation of the Spliceosomal B Complex (Homo sapiens)

as a component of

Inferred To

Ghost homologue of ISY1 [nucleoplasm] (Xenopus tropicalis)

ISY1 [nucleoplasm] (Canis familiaris)

ISY1 [nucleoplasm] (Gallus gallus)

ISY1 [nucleoplasm] (Saccharomyces cerevisiae)

ISY1 [nucleoplasm] (Sus scrofa)

cwf12 [nucleoplasm] (Schizosaccharomyces pombe)

Isy1 [nucleoplasm] (Mus musculus)

Isy1 [nucleoplasm] (Rattus norvegicus)

isy-1 [nucleoplasm] (Caenorhabditis elegans)

Dmel\CG9667 [nucleoplasm] (Drosophila melanogaster)

isy1 [nucleoplasm] (Danio rerio)

isy1 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001186398.1, NP_065752.1, NP_001191819.1

OpenTargets

ENSG00000240682

GeneCards

Q9ULR0

HPA

ENSG00000240682-ISY1

Ensembl

ENSG00000240682, ENST00000273541, ENST00000393295, ENSP00000273541, ENSP00000376973

PRO

Q9ULR0

Pharos - Targets

Q9ULR0

PDB

5YZG, 6ZYM, 6FF7, 7A5P

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.703	7
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.659	6
UniProt:Q9CSN1 Snw1	1	Snw1 [nucleoplasm] (R-MMU-2065315)	0.564	2
UniProt:Q8N131 PORIM			0.556	3
UniProt:Q8N371-3 KDM8			0.556	5
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:P36957 DLST	2	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:P25791-3 LMO2			0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.556	3
UniProt:Q8IYI6 EXOC8	2	EXOC8 [cytosol] (R-HSA-5623388) EXOC8 [plasma membrane] (R-HSA-264948)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 D522N [plasma membrane] (R-HSA-3640907) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 [plasma membrane] (R-HSA-170842) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 R528C [plasma membrane] (R-HSA-3640899)	0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [endoplasmic reticulum lumen] (R-HSA-195905)	0.556	3
UniProt:Q14562 DHX8			0.508	2

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