Reactome | USP10 deubiquitinates SNX3, CFTR

USP10 deubiquitinates SNX3, CFTR

Stable Identifier

R-HSA-6782106

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

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USP10 deubiquitinates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC (Boulkroun et al. 2008). USP10 deubiquitinates CFTR in early endosomes thereby enhancing its endocytic recycling (Bomberger et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19398555	The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells Bomberger, JM, Barnaby, RL, Stanton, BA	J. Biol. Chem.	2009
18632802	Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3 Boulkroun, S, Lagnaz, D, Staub, O, Ruffieux-Daidié, D, Charles, RP, Vitagliano, JJ, Kellenberger, S, Poirot, O, Firsov, D	Am. J. Physiol. Renal Physiol.	2008