5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER

Stable Identifier
R-HSA-6782204
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In transcription-coupled nucleotide excision repair (TC-NER), just like in global genome nucleotide excision repair (GG-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision by ERCC5 (XPG) (Staresincic et al. 2009).

Literature References
PubMed ID Title Journal Year
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD

EMBO J. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endodeoxyribonuclease activity of TC-NER incision complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created