Reactome | Gap-filling DNA repair synthesis and ligation in TC-NER

Gap-filling DNA repair synthesis and ligation in TC-NER

Stable Identifier

R-HSA-6782210

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

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Gap-filling DNA repair synthesis and ligation in TC-NER

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In transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fill in the single stranded gap that remains after dual incision. DNA ligases LIG1 or LIG3, the latter in complex with XRCC1, subsequently seal the single stranded nick by ligating the 3' end of the newly synthesized patch with the 5' end of incised DNA (Moser et al. 2007, Staresincic et al. 2009, Ogi et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19279666	Coordination of dual incision and repair synthesis in human nucleotide excision repair Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD	EMBO J.	2009
20227374	Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells Ogi, T, Limsirichaikul, S, Overmeer, RM, Volker, M, Takenaka, K, Cloney, R, Nakazawa, Y, Niimi, A, Miki, Y, Jaspers, NG, Mullenders, LH, Yamashita, S, Fousteri, M, Lehmann, AR	Mol. Cell	2010
17643379	Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner Moser, J, Kool, H, Giakzidis, I, Caldecott, K, Mullenders, LH, Fousteri, M	Mol. Cell	2007