In transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fill in the single stranded gap that remains after dual incision. DNA ligases LIG1 or LIG3, the latter in complex with XRCC1, subsequently seal the single stranded nick by ligating the 3' end of the newly synthesized patch with the 5' end of incised DNA (Moser et al. 2007, Staresincic et al. 2009, Ogi et al. 2010).

• Gap-filling DNA repair synthesis and ligation in TC-NER (Arabidopsis thaliana)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Bos taurus)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Caenorhabditis elegans)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Danio rerio)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Dictyostelium discoideum)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Drosophila melanogaster)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Gallus gallus)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Mus musculus)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Oryza sativa)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Rattus norvegicus)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Saccharomyces cerevisiae)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Schizosaccharomyces pombe)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Sus scrofa)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Taeniopygia guttata)
• Gap-filling DNA repair synthesis and ligation in TC-NER (Xenopus tropicalis)