Gap-filling DNA repair synthesis and ligation in TC-NER

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R-HSA-6782210
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Homo sapiens
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In transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fill in the single stranded gap that remains after dual incision. DNA ligases LIG1 or LIG3, the latter in complex with XRCC1, subsequently seal the single stranded nick by ligating the 3' end of the newly synthesized patch with the 5' end of incised DNA (Moser et al. 2007, Staresincic et al. 2009, Ogi et al. 2010).

Literature References
PubMed ID Title Journal Year
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD

EMBO J. 2009
20227374 Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

Ogi, T, Limsirichaikul, S, Overmeer, RM, Volker, M, Takenaka, K, Cloney, R, Nakazawa, Y, Niimi, A, Miki, Y, Jaspers, NG, Mullenders, LH, Yamashita, S, Fousteri, M, Lehmann, AR

Mol. Cell 2010
17643379 Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner

Moser, J, Kool, H, Giakzidis, I, Caldecott, K, Mullenders, LH, Fousteri, M

Mol. Cell 2007
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