DNA polymerases delta, epsilon or kappa bind the TC-NER site

Stable Identifier
R-HSA-6782211
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The DNA repair synthesis complex, consisting of PCNA, RFC, RPA and polymerase delta (POLD) or epsilon (POLE) complexes, or polymerase kappa (POLK), is formed at the transcription coupled nucleotide excision repair (TC-NER) site, as well as the global genome nucleotide excision repair (GG-NER) site, following the incision of the damaged DNA strand 5' to the lesion by the ERCC1:ERCC4 (ERCC1:XPF) complex. 3' incision by XPG (ERCC5) is not required for the loading of the DNA polymerases and may not be required for the initiation of NER-mediated DNA synthesis (Staresincic et al. 2009). XPG and RPA promote the assembly of the DNA synthesis complex at the NER site (Mocquet et al. 2008).

Literature References
PubMed ID Title Journal Year
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD

EMBO J. 2009
18079701 Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step

Mocquet, V, Lainé, JP, Riedl, T, Yajin, Z, Lee, MY, Egly, JM

EMBO J. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed