Ligation of newly synthesized repair patch to incised DNA in TC-NER

Stable Identifier
R-HSA-6782227
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The nucleotide excision repair (NER) is completed when the newly synthesized fragment is ligated to the incised DNA strand, thus sealing the single stranded nick (SSB). Two DNA ligases, LIG1 and LIG3 (as a part of LIG3:XRCC1 complex) can perform the ligation in transcription-coupled NER (TC-NER), as well as in global genome NER (GG-NER). The choice of NER DNA ligase depends on the DNA polymerase involved in repair synthesis and probably the stage of the cell cycle (Moser et al. 2007).

Literature References
PubMed ID Title Journal Year
17643379 Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner

Moser, J, Kool, H, Giakzidis, I, Caldecott, K, Mullenders, LH, Fousteri, M

Mol. Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA ligase activity of LIG1,LIG3:XRCC1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed