METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46

Stable Identifier
R-HSA-6782286
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The METTL1:WDR4 complex transfers a methyl group from S-adenosylmethionine to guanosine-46 of tRNA(Phe), yielding 7-methylguanosine-46 (Alexandrov et al. 2002, Cartlidge et al. 2005). A homologous complex, Trm8p:Trm82p, exists in Saccharomyces cerevisiae and catalyzes the same reaction.

Literature References
PubMed ID Title Journal Year
12403464 Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA

Alexandrov, A, Martzen, MR, Phizicky, EM

RNA 2002
15861136 The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

Cartlidge, RA, Knebel, A, Peggie, M, Alexandrov, A, Phizicky, EM, Cohen, P

EMBO J. 2005
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Catalyst Activity
Title
tRNA (guanine-N7-)-methyltransferase activity of METTL1:WDR4 [nucleoplasm]
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