tRNA modification in the nucleus and cytosol

Stable Identifier
R-HSA-6782315
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Pathway
Species
Homo sapiens
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At least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and mitochondria (reviewed in Boschi-Muller and Motorin 2013, Jackman and Alfonzo 2013, Gu et al. 2014, Helm and Alfonzo 2014, Li and Mason 2014). Modifications near the anticodon and near the 3' end affect interaction of the tRNA with ribosomes and tRNA synthetases, respectively, while modifications in other regions of the tRNA affect folding and stability of the tRNA (reviewed in Hou et al. 2015). Mutations in tRNA modification enzymes are associated with human diseases (reviewed in Sarin and Leidel 2014, Torres et al. 2014).

Literature References
PubMed ID Title Journal Year
25304425 tRNA modifications regulate translation during cellular stress

Gu, C, Begley, TJ, Dedon, PC

FEBS Lett. 2014
24490730 Chemistry enters nucleic acids biology: enzymatic mechanisms of RNA modification

Boschi-Muller, S, Motorin, Y

Biochemistry Mosc. 2013
25780173 Post-transcriptional modifications to tRNA--a response to the genetic code degeneracy

Hou, YM, Gamper, H, Yang, W

RNA 2015
24898039 The pivotal regulatory landscape of RNA modifications

Li, S, Mason, CE

Annu Rev Genomics Hum Genet 2014
23139145 Transfer RNA modifications: nature's combinatorial chemistry playground

Jackman, JE, Alfonzo, JD

Wiley Interdiscip Rev RNA 2013
24581449 Role of tRNA modifications in human diseases

Torres, AG, Batlle, E, Ribas de Pouplana, L

Trends Mol Med 2014
25692999 Modify or die?--RNA modification defects in metazoans

Sarin, LP, Leidel, SA

RNA Biol 2014
24315934 Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland

Helm, M, Alfonzo, JD

Chem. Biol. 2014
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