Reactome | NSUN2 [nucleoplasm]

NSUN2 [nucleoplasm]

Stable Identifier

R-HSA-6782382

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

tRNA methyltransferase 4 homolog, NSUN2_HUMAN, hTrm4

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08J23 NSUN2

Gene Names

NSUN2, SAKI, TRM4

Chain

chain:1-767

Reference Genes

BioGPS Gene:54888 NSUN2

COSMIC (genes):NSUN2 NSUN2

CTD Gene:54888 NSUN2

dbSNP Gene:54888 NSUN2

ENSEMBL:ENSG00000037474 NSUN2

HGNC:25994 NSUN2

Monarch:54888 NSUN2

NCBI Gene:54888 NSUN2

OMIM:610916 NSUN2

UCSC:Q08J23 NSUN2

Reference Transcript

Other Identifiers

11717461_a_at

11717462_s_at

11717463_x_at

11756663_a_at

16994170

223076_PM_s_at

223076_s_at

2847333

2847334

2847335

2847336

2847340

2847342

2847343

2847344

2847345

2847346

2847347

2847348

2847349

2847350

2847351

2847352

2847354

2847356

2847357

2847358

2847359

2847360

2847361

2847362

2847363

2847364

2847367

2847370

2847371

2847372

3179301

54763_at

54888

8110894

A_23_P7423

GE56798

GO:0000049

GO:0001510

GO:0001701

GO:0003723

GO:0003824

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0005819

GO:0005856

GO:0006397

GO:0006399

GO:0006400

GO:0007283

GO:0007286

GO:0008033

GO:0008168

GO:0008173

GO:0010793

GO:0016071

GO:0016428

GO:0016740

GO:0022414

GO:0030154

GO:0030488

GO:0032259

GO:0033313

GO:0033391

GO:0036416

GO:0043226

GO:0048820

GO:0048856

GO:0051301

GO:0062152

GO:0070062

GO:0140098

GO:2000736

HMNXSV003047900

ILMN_1680129

PH_hs_0024072

TC05001138.hg

TC05002839.hg

g12654430_3p_a_at

Cross References

ENSEMBL

ENST00000264670, ENSP00000420957, ENST00000506139, ENSP00000264670

OpenTargets

ENSG00000037474

HPA

ENSG00000037474-NSUN2

PRO

Q08J23

Pharos - Targets

Q08J23

GlyGen

Q08J23

Orphanet

NSUN2

HMDB Protein

HMDBP07251

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.527	2
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.527	2
UniProt:Q9NZW5 PALS2			0.527	2
UniProt:Q08830 FGL1			0.527	2
UniProt:Q86U44 METTL3	1	METTL3 [nucleoplasm] (R-HSA-72091)	0.527	2
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.527	2
UniProt:O14910 LIN7A	2	LIN7A [plasma membrane] (R-HSA-5216076) LIN7A [transport vesicle membrane] (R-HSA-9610413)	0.527	2
UniProt:Q05086 UBE3A	1	UBE3A [cytosol] (R-HSA-976028)	0.499	2
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.483	2
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.483	2
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.483	2
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.483	2

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