TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)

Stable Identifier
R-HSA-6782419
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)
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TRDMT1 (DNMT2) transfers a methyl group from S-adenosylmethionine to the 5 position of cytidine-38 of tRNA(Asp) (Goll et al. 2006, Jurkowski et al. 2008, Jurkowski et al. 2012). TRDMT1 uses a similar mechanism to DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) (Jurkowski et al. 2008).
Literature References
PubMed ID Title Journal Year
16424344 Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

Maggert, KA, Golic, KG, Yoder, JA, Kirpekar, F, Hsieh, CL, Zhang, X, Bestor, TH, Goll, MG, Jacobsen, SE

Science 2006
18567810 Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism

Nellen, W, Phalke, S, Jurkowski, TP, Reuter, G, Helm, M, Jeltsch, A, Meusburger, M

RNA 2008
22591353 Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase

Shanmugam, R, Jurkowski, TP, Helm, M, Jeltsch, A

Biochemistry 2012
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (cytosine-5-)-methyltransferase activity of TRDMT1 [nucleoplasm]

Physical Entity
TRDMT1 [nucleoplasm] (Homo sapiens)
Activity
tRNA (cytosine-5-)-methyltransferase activity (GO:0016428)
Authored
May, B  (2015-06-07)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-08)
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