Reactome | Ub-HIST1H2AB [nucleoplasm]

Ub-HIST1H2AB [nucleoplasm]

Stable Identifier

R-HSA-6782483

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HIST1H2AB

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04908 H2AC4

Gene Names

H2AC4, H2AFM, HIST1H2AB, H2AC8, H2AFA, HIST1H2AE

Chain

initiator methionine:1, chain:2-130

Reference Genes

BioGPS Gene:3012 H2AC4

BioGPS Gene:8335 H2AC4

CTD Gene:3012 H2AC4

CTD Gene:8335 H2AC4

dbSNP Gene:3012 H2AC4

dbSNP Gene:8335 H2AC4

ENSEMBL:ENSG00000277075 HIST1H2AE

ENSEMBL:ENSG00000278463 HIST1H2AB

HGNC:4724 H2AC4

HGNC:4734 H2AC4

KEGG Gene (Homo sapiens):3012 H2AC4

KEGG Gene (Homo sapiens):8335 H2AC4

Monarch:3012 H2AC4

Monarch:8335 H2AC4

NCBI Gene:3012 H2AC4

NCBI Gene:8335 H2AC4

OMIM:602786 H2AC4

OMIM:602795 H2AC4

Reference Transcript

Other Identifiers

0005130670

0006020338

11731693_at

11731694_s_at

11741215_at

17005589

17016366

208569_at

214469_at

2899224

2899225

2899226

2946220

2946221

2946222

2946223

2946224

3012

35127_at

8117408

8124391

8335

A_14_P115530

A_23_P59045

A_24_P223384

GE504811

GO:0000228

GO:0000786

GO:0000790

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005694

GO:0006325

GO:0006342

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0032991

GO:0034641

GO:0043226

GO:0046982

GO:0051276

GO:0070062

Hs.121017.0.S1_3p_at

ILMN_1753524

ILMN_1756849

M60752_at

PH_hs_0013174

PH_hs_0032313

TC06000173.hg

TC06001343.hg

Z83741_at

g4504246_3p_at

Participant Of

hasMember

Ub-histone HIST1 H2A [nucleoplasm]

Other forms of this molecule

HIST1H2AB [extracellular region]

K63polyUb-HIST1H2AB [nucleoplasm]

Ack6-HIST1H2AB [nucleoplasm]

Ack-HIST1H2AB [nucleoplasm]

Me2aR30-HIST1H2AB [nucleoplasm]

MeR30-HIST1H2AB [nucleoplasm]

Me2aR4-HIST1H2AB [nucleoplasm]

MeR4-HIST1H2AB [nucleoplasm]

Me2sR4-HIST1H2AB [nucleoplasm]

Me2aR12-HIST1H2AB [nucleoplasm]

MeR12-HIST1H2AB [nucleoplasm]

HIST1H2AB [nucleoplasm]

Inferred To

Hist1h2ap [nucleoplasm] (Mus musculus)

hist1h2ah [nucleoplasm] (Xenopus tropicalis)

HTA1 [nucleoplasm] (Saccharomyces cerevisiae)

Ub-HIST3H2A [nucleoplasm] (Plasmodium falciparum)

Ub-HIST3H2A [nucleoplasm] (Xenopus tropicalis)

HTA2 [nucleoplasm] (Saccharomyces cerevisiae)

LOC100492813 [nucleoplasm] (Xenopus tropicalis)

H2Av2 [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ub-HIST3H2A [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ub-HIST3H2A [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of Ub-HIST3H2A [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of Ub-HIST3H2A [nucleoplasm] (Xenopus tropicalis)

LOC100158121 [nucleoplasm] (Sus scrofa)

hist2h2ab [nucleoplasm] (Xenopus tropicalis)

slc25a43 [nucleoplasm] (Xenopus tropicalis)

wbp2nl [nucleoplasm] (Xenopus tropicalis)

Hist1h2ao [nucleoplasm] (Mus musculus)

hta1 [nucleoplasm] (Schizosaccharomyces pombe)

Hist1h2af [nucleoplasm] (Mus musculus)

h2afx [nucleoplasm] (Xenopus tropicalis)

ppard [nucleoplasm] (Xenopus tropicalis)

H2ac12 [nucleoplasm] (Mus musculus)

hta2 [nucleoplasm] (Schizosaccharomyces pombe)

mpped1 [nucleoplasm] (Xenopus tropicalis)

hist1h2ad [nucleoplasm] (Xenopus tropicalis)

H2ac4 [nucleoplasm] (Mus musculus)

H2ac6 [nucleoplasm] (Mus musculus)

Hist1h2an [nucleoplasm] (Mus musculus)

h2ax [nucleoplasm] (Danio rerio)

H2AC8 [nucleoplasm] (Bos taurus)

H2ac15 [nucleoplasm] (Mus musculus)

H2AX [nucleoplasm] (Dictyostelium discoideum)

H2Av3 [nucleoplasm] (Dictyostelium discoideum)

htas-1 [nucleoplasm] (Caenorhabditis elegans)

Ub-HIST1H2AB [nucleoplasm] (Canis familiaris)

H2Av1 [nucleoplasm] (Dictyostelium discoideum)

H2ac13 [nucleoplasm] (Mus musculus)

H2ac8 [nucleoplasm] (Mus musculus)

Homologues of Ub-HIST1H2AB [nucleoplasm] (Mus musculus)

H2ac11 [nucleoplasm] (Mus musculus)

Modified Residues

Name

ubiquitinylated lysine at 120

Coordinate

120

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_066390.1, NP_003504.2

OpenTargets

ENSG00000278463

GeneCards

P04908

HPA

ENSG00000277075-HIST1H2AE, ENSG00000278463-HIST1H2AB

Ensembl

ENSG00000277075, ENSG00000278463, ENST00000303910, ENSP00000303373, ENST00000615868, ENSP00000483842

PRO

P04908

HMDB Protein

HMDBP07727

PDB

3AV2, 6IPU, 3X1S, 6INQ, 3AZI, 5XF4, 5AV5, 5B2I, 5AV8, 3AZH, 5AY8, 6R91, 5Y0D, 6JXD, 5ZBX, 5CPJ, 6R93, 6V92, 6R8Z, 3AYW, 3AZJ, 5GXQ, 3AZF, 5Z23, 3AZE, 6J50, 6JR0, 6IR9, 6J4W, 6A5P, 6A5T, 4YM6, 6J4Y, 6R90, 3AZM, 6E0P, 3W96, 5B31, 2RVQ, 6L4A, 3W98, 5AVB, 6A5L, 5B0Y, 6IQ4, 2CV5, 3X1V, 3AN2, 6O1D, 5XF3, 6E0C, 5XF5, 6AEE, 5AV6, 3AV1, 3AZK, 5B2J, 6R92, 5Y0C, 5GTC, 5CPI, 6R8Y, 6R94, 5B24, 5B40, 6HTS, 5CPK, 3WTP, 3AFA, 5JRG, 3A6N, 6J51, 6A5O, 6HKT, 4Z5T, 6J4X, 4YM5, 6J4Z, 6JR1, 6A5R, 6A5U, 6L49, 5AV9, 3AZL, 3AZG, 6BUZ, 5GSE, 6ACL, 3AZN, 3W97, 5X7X, 5B32, 3W99, 3WKJ, 5AVC, 5B0Z

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.835	11
UniProt:Q16695 H3-4	3	Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186) HIST3H3 [nucleoplasm] (R-HSA-181914)	0.589	2

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