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Ub-HIST1H2AB [nucleoplasm]
Stable Identifier
R-HSA-6782483
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HIST1H2AB
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Metalloprotease DUBs (Homo sapiens)
MYSM1 deubiquitinates Histone H2A (Homo sapiens)
MYSM1:EP300:KAT2B:Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone HIST1 H2A [nucleoplasm] (Homo sapiens)
Ub-HIST1H2AB [nucleoplasm] (Homo sapiens)
UCH proteinases (Homo sapiens)
Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone HIST1 H2A [nucleoplasm] (Homo sapiens)
Ub-HIST1H2AB [nucleoplasm] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)
USP16,USP21:Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone HIST1 H2A [nucleoplasm] (Homo sapiens)
Ub-HIST1H2AB [nucleoplasm] (Homo sapiens)
USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
Ub-histone H2A [nucleoplasm] (Homo sapiens)
Ub-histone HIST1 H2A [nucleoplasm] (Homo sapiens)
Ub-HIST1H2AB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04908 H2AC4
Gene Names
H2AC4, H2AFM, HIST1H2AB, H2AC8, H2AFA, HIST1H2AE
Chain
initiator methionine:1, chain:2-130
Reference Genes
BioGPS Gene:3012 H2AC4
BioGPS Gene:8335 H2AC4
CTD Gene:3012 H2AC4
CTD Gene:8335 H2AC4
dbSNP Gene:3012 H2AC4
dbSNP Gene:8335 H2AC4
ENSEMBL:ENSG00000277075 HIST1H2AE
ENSEMBL:ENSG00000278463 HIST1H2AB
HGNC:4724 H2AC4
HGNC:4734 H2AC4
KEGG Gene (Homo sapiens):3012 H2AC4
KEGG Gene (Homo sapiens):8335 H2AC4
Monarch:3012 H2AC4
Monarch:8335 H2AC4
NCBI Gene:3012 H2AC4
NCBI Gene:8335 H2AC4
OMIM:602786 H2AC4
OMIM:602795 H2AC4
Reference Transcript
RefSeq:NM_003513.2 H2AC4
RefSeq:NM_021052.2 H2AC4
Other Identifiers
0005130670
0006020338
11731693_at
11731694_s_at
11741215_at
17005589
17016366
208569_at
214469_at
2899224
2899225
2899226
2946220
2946221
2946222
2946223
2946224
3012
35127_at
8117408
8124391
8335
A_14_P115530
A_23_P59045
A_24_P223384
GE504811
GO:0000785
GO:0000786
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005694
GO:0006342
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0032991
GO:0034641
GO:0043226
GO:0046982
GO:0051276
GO:0070062
HMNXSV003010811
HMNXSV003012591
Hs.121017.0.S1_3p_at
ILMN_1753524
ILMN_1756849
M60752_at
PH_hs_0013174
PH_hs_0032313
TC06000173.hg
TC06001343.hg
Z83741_at
g4504246_3p_at
Participates
as a member of
Ub-histone HIST1 H2A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
HIST1H2AB [extracellular region]
K63polyUb-HIST1H2AB [nucleoplasm]
Ack6-HIST1H2AB [nucleoplasm]
Ack-HIST1H2AB [nucleoplasm]
Me2aR30-HIST1H2AB [nucleoplasm]
MeR30-HIST1H2AB [nucleoplasm]
Me2aR4-HIST1H2AB [nucleoplasm]
MeR4-HIST1H2AB [nucleoplasm]
Me2sR4-HIST1H2AB [nucleoplasm]
Me2aR12-HIST1H2AB [nucleoplasm]
MeR12-HIST1H2AB [nucleoplasm]
HIST1H2AB [nucleoplasm]
Inferred To
Hist1h2ap [nucleoplasm]
(Mus musculus)
h2ax1 [nucleoplasm]
(Danio rerio)
H2ac4 [nucleoplasm]
(Mus musculus)
Ub-HIST3H2A [nucleoplasm]
(Plasmodium falciparum)
Ub-HIST3H2A [nucleoplasm]
(Xenopus tropicalis)
H2ac6 [nucleoplasm]
(Mus musculus)
Hist1h2an [nucleoplasm]
(Mus musculus)
H2AC8 [nucleoplasm]
(Bos taurus)
H2ac15 [nucleoplasm]
(Mus musculus)
H2AC11 [nucleoplasm]
(Canis familiaris)
H2Av3 [nucleoplasm]
(Dictyostelium discoideum)
htas-1 [nucleoplasm]
(Caenorhabditis elegans)
Hist1h2ao [nucleoplasm]
(Mus musculus)
H2ac13 [nucleoplasm]
(Mus musculus)
H2ac8 [nucleoplasm]
(Mus musculus)
Homologues of Ub-HIST1H2AB [nucleoplasm]
(Mus musculus)
H2ac11 [nucleoplasm]
(Mus musculus)
Hist1h2af [nucleoplasm]
(Mus musculus)
H2ac12 [nucleoplasm]
(Mus musculus)
Modified Residues
Name
ubiquitinylated lysine at 120
Coordinate
120
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_066390.1
,
NP_003504.2
Target Pathogen
57c08b76be737e1cc0a95c6b
,
57c09037be737e1cc0a96c46
,
57c08b76be737e1cc0a95c69
OpenTargets
ENSG00000278463
GeneCards
P04908
HPA
ENSG00000277075-HIST1H2AE
,
ENSG00000278463-HIST1H2AB
Ensembl
ENST00000615868
,
ENST00000303910
,
ENSG00000277075
,
ENSP00000483842
,
ENSG00000278463
,
ENSP00000303373
PRO
P04908
HMDB Protein
HMDBP07727
PDB
6R94
,
3AZI
,
6JXD
,
5CPI
,
3AZK
,
3AZH
,
5CPJ
,
6LE9
,
3AZL
,
3AZG
,
5CPK
,
3AZM
,
3AZF
,
3AZN
,
3AFA
,
6A5L
,
6HTS
,
2CV5
,
5GXQ
,
6AEE
,
6V92
,
6A5O
,
6JR0
,
3AV2
,
3AN2
,
6INQ
,
6A5P
,
6L49
,
3AV1
,
5AV5
,
6L4A
,
6A5T
,
5AV6
,
6IQ4
,
6A5R
,
5ZBX
,
6JR1
,
6A5U
,
5AV8
,
6HKT
,
5AV9
,
5AVB
,
5AVC
,
7CCQ
,
6T79
,
3X1S
,
5Z23
,
6T7A
,
6IR9
,
7CCR
,
3W97
,
3X1V
,
6T7C
,
3W98
,
6T7B
,
3W99
,
6IPU
,
5Y0D
,
6T7D
,
5GSE
,
6KE9
,
5XF4
,
5XF5
,
6M44
,
6LA9
,
5GTC
,
6LA8
,
5B0Y
,
3W96
,
6J4X
,
6T90
,
5B0Z
,
6J4W
,
5Y0C
,
6J4Y
,
6J51
,
5JRG
,
3AYW
,
6T93
,
6J50
,
6E0C
,
5AY8
,
3WKJ
,
6J4Z
,
5XF3
,
2RVQ
,
6E0P
,
5B24
,
6O1D
,
5B40
,
6M3V
,
4Z5T
,
4YM5
,
4YM6
,
3WTP
,
5B2I
,
5B2J
,
3AZE
,
6L9H
,
6KXV
,
5B31
,
5B32
,
6BUZ
,
6ACL
,
6R8Z
,
6R91
,
6R8Y
,
6R90
,
7C0M
,
6R93
,
6YOV
,
6R92
,
5X7X
,
3AZJ
,
3A6N
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
19
SUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
HIST1H4A [extracellular region]
(R-HSA-977569)
SUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-4568749)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
MeK-HIST1H4A [nucleoplasm]
(R-HSA-2172676)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
0.835
11
UniProt:Q16695 H3-4
3
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
HIST3H3 [nucleoplasm]
(R-HSA-181914)
0.589
2
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