Reactome | Ub-27-RPS27A(1-76) [nucleoplasm]

Ub-27-RPS27A(1-76) [nucleoplasm]

Stable Identifier

R-HSA-6782671

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
        
        PolyUb [nucleoplasm] (Homo sapiens)
        
        K27polyUb [nucleoplasm] (Homo sapiens)
        
        K27-Ub [nucleoplasm] (Homo sapiens)
        
        Ub-27-RPS27A(1-76) [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62979 RPS27A

Gene Names

RPS27A, UBA80, UBCEP1

Chain

chain:1-76, chain:77-156

Reference Genes

BioGPS Gene:6233 RPS27A

COSMIC (genes):RPS27A RPS27A

CTD Gene:6233 RPS27A

dbSNP Gene:6233 RPS27A

ENSEMBL:ENSG00000143947 RPS27A

ENSEMBL:ENSG00000143947.15 RPS27A

HGNC:10417 RPS27A

KEGG Gene (Homo sapiens):6233 RPS27A

Monarch:6233 RPS27A

NCBI Gene:6233 RPS27A

OMIM:191343 RPS27A

UCSC:P62979 RPS27A

Reference Transcript

Other Identifiers

11741791_at

11744329_x_at

17119982

18670232

18670234

18670235

18670237

18670241

18670243

18670244

200017_PM_at

200017_at

242214_PM_at

242214_at

2482925

2482928

2482929

2482930

2482932

2482933

2482937

2482940

2482941

2482942

34570_at

3694166

3694168

3694170

3694172

6233

7893392

7893455

7893919

7894376

7894813

7894844

7908407

8001782

8042052

83250_at

A_23_P79732

GE716822

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0005741

GO:0005768

GO:0005783

GO:0005789

GO:0005829

GO:0005840

GO:0005886

GO:0006412

GO:0010008

GO:0016020

GO:0016567

GO:0019941

GO:0022626

GO:0022627

GO:0030163

GO:0030666

GO:0031386

GO:0031410

GO:0031625

GO:0031982

GO:0032040

GO:0036211

GO:0043226

GO:0045202

GO:0046872

GO:0070062

GO:1990904

HMNXSV003033635

Hs.311640.0.A1_3p_at

Hs.328922.0.A1_3p_at

ILMN_2048326

S79522_at

TC01004921.hg

TC02000321.hg

g4506712_3p_at

g4506712_3p_x_at

Participates

as a member of

K27-Ub [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPS27A(1-76) [endocytic vesicle membrane]

RPS27A(77-156) [nucleoplasm]

Ub-33-RPS27A(1-76) [mitochondrial outer membrane]

Ub-63-RPS27A(1-76) [mitochondrial outer membrane]

Ub-6-RPS27A(1-76) [mitochondrial outer membrane]

Ub-11-RPS27A(1-76) [mitochondrial outer membrane]

Ub-48-RPS27A(1-76) [mitochondrial outer membrane]

Ub-29-RPS27A(1-76) [mitochondrial outer membrane]

Ub-27-RPS27A(1-76) [mitochondrial outer membrane]

N6-glycyl-L-lysine-RPS27A(1-76) [cytosol]

adenylatedlG76-RPS27A(1-76) [nucleoplasm]

RPS27A [cytosol]

adenylatedlG76-RPS27A(1-76) [cytosol]

Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane]

Ub-48-RPS27A(1-76) [lysosomal membrane]

Ub-48-RPS27A(1-76) [endocytic vesicle membrane]

RPS27A(1-76) [endosome membrane]

RPS27A(1-76) [plasma membrane]

Ub-29-RPS27A(1-76) [cytosol]

Ub-6-RPS27A(1-76) [cytosol]

Ub-33-RPS27A(1-76) [cytosol]

Ub-27-RPS27A(1-76) [cytosol]

M1-RPS27A(1-76) [cytosol]

RPS27A(77-156) [cytosol]

RPS27A(1-76) [endoplasmic reticulum membrane]

Ub-29-RPS27A(1-76) [nucleoplasm]

Ub-33-RPS27A(1-76) [nucleoplasm]

Ub-11-RPS27A(1-76) [nucleoplasm]

Ub-63-RPS27A(1-76) [endosome membrane]

Ub-63-RPS27A(1-76) [plasma membrane]

Ub-11-RPS27A(1-76) [cytosol]

Ub-48-RPS27A(1-76) [nucleoplasm]

RPS27A(1-76) [nucleoplasm]

Ub-63-RPS27A(1-76) [nucleoplasm]

Ub-6-RPS27A(1-76) [nucleoplasm]

RPS27A(1-76) [late endosome lumen]

Ub-48-RPS27A(1-76) [cytosol]

RPS27A(1-76) [cytosol]

RPS27A(1-76) [lysosomal lumen]

Ub-63-RPS27A(1-76) [cytosol]

Inferred To

UBB [nucleoplasm] (Bos taurus)

ubqJ [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ub-27-RPS27A(1-76) [nucleoplasm] (Dictyostelium discoideum)

ubqI [nucleoplasm] (Dictyostelium discoideum)

ubqD [nucleoplasm] (Dictyostelium discoideum)

ubqC [nucleoplasm] (Dictyostelium discoideum)

RPS27A [nucleoplasm] (Sus scrofa)

ubqB [nucleoplasm] (Dictyostelium discoideum)

Uba52 [nucleoplasm] (Mus musculus)

Uba52 [nucleoplasm] (Rattus norvegicus)

ubqG [nucleoplasm] (Dictyostelium discoideum)

RpL40 [nucleoplasm] (Drosophila melanogaster)

Ub-27-RPS27A(1-76) [nucleoplasm] (Canis familiaris)

Ub-27-RPS27A(1-76) [nucleoplasm] (Danio rerio)

Ub-27-RPS27A(1-76) [nucleoplasm] (Xenopus tropicalis)

ubqH [nucleoplasm] (Dictyostelium discoideum)

ubqF [nucleoplasm] (Dictyostelium discoideum)

Modified Residues

Name

ubiquitinylated lysine at 27

Coordinate

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001170884.1, NP_001129064.1, NP_002945.1

OpenTargets

ENSG00000143947

HPA

ENSG00000143947-RPS27A

GeneCards

P62979

Ensembl

ENSP00000272317, ENST00000404735, ENSP00000385659, ENST00000272317, ENST00000402285, ENSG00000143947, ENSP00000383981

PRO

P62979

Pharos - Targets

P62979

Orphanet

24875

PDB

6ZP4, 6KFP, 7WU0, 3TBL, 6IP5, 6ZON, 5YDK, 6G18, 6YBS, 6G51, 6OLZ, 6OM0, 6OLF, 7QP6, 2KWV, 3PHD, 7WTT, 6ZXD, 7WTU, 7QP7, 7K5I, 6SQO, 7OOJ, 6KIU, 3NS8, 6KIW, 6SQR, 6G5H, 6ZV6, 6ZXG, 6Y0G, 6ZMI, 7WTV, 5T2C, 7MQA, 6J99, 5LKS, 7WTW, 7A09, 2L0F, 2KTF, 6ZVH, 6Z6L, 6ZMT, 7JQC, 6Y57, 7MQ9, 4V6X, 6ZVJ, 5AJ0, 6ZXH, 5WVO, 6DC6, 5FLX, 6ZLW, 7JQB, 6XA1, 6IP6, 3K9P, 6OLE, 7R4X, 7TQL, 6OM7, 3NHE, 3AXC, 2KOX, 2KWU, 6KG6, 6OLG, 6G53, 2L0T, 6Z6N, 6ZN5, 6ZM7, 6KIV, 3I3T, 6SQS, 6ZXF, 6FEC, 3PHW, 2KHW, 6ZME, 3NOB, 7BWD, 7WTX, 7WTZ, 6G5I, 6ZMO, 6IP8, 6ZUO, 6ZXE, 6QZP, 6Z6M, 3VDZ, 4R62, 2XK5, 6ZOL, 6OLI, 4UG0, 3N32, 3N30, 5A2Q, 6ZMW, 6ZOJ

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15038 DAZP2			0.781	9
UniProt:Q9Y3C5 RNF11			0.666	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.607	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q99732 LITAF			0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q9NRQ2 PLS4			0.556	3
UniProt:I6L9I8 I6L9I8			0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:Q92567-2 FAM168A			0.556	3
UniProt:Q6ICB0 DESI1			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6

Cite Us!