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Ub-SMAD1 [cytosol]
Stable Identifier
R-HSA-6782768
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SMAD1, R-Smad1, Mothers against decapentaplegic homolog 1, SMA1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
Ub-SMAD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15797 SMAD1
Gene Names
SMAD1, BSP1, MADH1, MADR1
Chain
chain:1-465
Reference Genes
BioGPS Gene:4086 SMAD1
COSMIC (genes):SMAD1 SMAD1
CTD Gene:4086 SMAD1
dbSNP Gene:4086 SMAD1
ENSEMBL:ENSG00000170365 SMAD1
HGNC:6767 SMAD1
KEGG Gene (Homo sapiens):4086 SMAD1
Monarch:4086 SMAD1
NCBI Gene:4086 SMAD1
OMIM:601595 SMAD1
UCSC:Q15797 SMAD1
Reference Transcript
RefSeq:XM_006714217.2 SMAD1
RefSeq:XM_011531962.1 SMAD1
RefSeq:XM_011531961.1 SMAD1
RefSeq:XM_011531963.1 SMAD1
RefSeq:XM_011531964.1 SMAD1
RefSeq:NM_005900.2 SMAD1
RefSeq:XM_005262992.3 SMAD1
RefSeq:NM_001003688.1 SMAD1
Other Identifiers
11723044_at
11747501_a_at
1325_at
210993_s_at
227798_at
2746118
2746120
2746121
2746122
2746123
2746124
2746125
2746126
2746127
2746130
2746131
2746138
2746141
2746142
2746144
2746147
2746150
2746151
37280_at
4086
50875_at
8097657
A_14_P103768
A_23_P212870
A_24_P71938
GE59266
GE84973
GO:0000003
GO:0000165
GO:0000785
GO:0000978
GO:0000981
GO:0001228
GO:0001657
GO:0001710
GO:0002051
GO:0003674
GO:0003677
GO:0003700
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005637
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006464
GO:0006468
GO:0006950
GO:0006954
GO:0007165
GO:0007179
GO:0007183
GO:0007276
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0009653
GO:0009790
GO:0009880
GO:0010628
GO:0016021
GO:0016579
GO:0017151
GO:0019899
GO:0019901
GO:0022607
GO:0030154
GO:0030509
GO:0030901
GO:0030902
GO:0031053
GO:0032991
GO:0034641
GO:0040007
GO:0042592
GO:0042802
GO:0043167
GO:0043226
GO:0043565
GO:0045669
GO:0045944
GO:0046872
GO:0048646
GO:0048856
GO:0051216
GO:0060038
GO:0060348
GO:0060395
GO:0061036
GO:0065003
GO:0070410
GO:0070411
GO:0070878
GO:0071141
GO:0071144
GO:0071407
GO:0071773
GO:1901522
GO:1902895
GO:1903672
HMNXSV003005904
Hs.322710.0.A1_3p_at
ILMN_1670540
ILMN_1705392
PH_hs_0024460
PH_hs_0032859
TC04000711.hg
U59423_at
g1332713_3p_a_at
Participates
as a member of
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
Other forms of this molecule
SMAD1 [cytosol]
p-S463,S465-SMAD1 [cytosol]
p-S463,S465-SMAD1 [nucleoplasm]
Inferred To
smad1 [cytosol]
(Danio rerio)
Smad1 [cytosol]
(Mus musculus)
Smad1 [cytosol]
(Rattus norvegicus)
sma-2 [cytosol]
(Caenorhabditis elegans)
daf-14 [cytosol]
(Caenorhabditis elegans)
Homologues of Ub-SMAD1 [cytosol]
(Caenorhabditis elegans)
sma-3 [cytosol]
(Caenorhabditis elegans)
SMAD1 [cytosol]
(Canis familiaris)
SMAD1 [cytosol]
(Gallus gallus)
SMAD1 [cytosol]
(Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005263049.1
,
XP_011530264.1
,
XP_011530266.1
,
XP_011530265.1
,
XP_006714280.1
,
NP_005891.1
,
NP_001003688.1
,
XP_011530263.1
OpenTargets
ENSG00000170365
HPA
ENSG00000170365-SMAD1
GeneCards
Q15797
Ensembl
ENST00000394092
,
ENST00000302085
,
ENSP00000426568
,
ENSG00000170365
,
ENSP00000305769
,
ENST00000515385
,
ENSP00000377652
PRO
Q15797
PDB
3Q4A
,
5ZOK
,
2LAY
,
3Q47
,
2LB1
,
2LB0
,
2LAZ
,
2LAX
,
2LAW
,
1KHU
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13485 SMAD4
88
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
SMAD4 E417* [cytosol]
(R-HSA-9675623)
SMAD4 Y195* [cytosol]
(R-HSA-9678462)
SMAD4 E108* [cytosol]
(R-HSA-9675640)
SMAD4 S343* [cytosol]
(R-HSA-9675641)
SMAD4 E520* [cytosol]
(R-HSA-9675636)
SMAD4 G510* [cytosol]
(R-HSA-9678452)
SMAD4 G358* [cytosol]
(R-HSA-9678453)
SMAD4 E175* [cytosol]
(R-HSA-9675637)
SMAD4 E307* [cytosol]
(R-HSA-9675639)
SMAD4 E53* [cytosol]
(R-HSA-9675633)
SMAD4 S171* [cytosol]
(R-HSA-9675634)
SMAD4 G30* [cytosol]
(R-HSA-9678450)
SMAD4 G168* [cytosol]
(R-HSA-9678451)
SMAD4 Q366* [cytosol]
(R-HSA-9675200)
SMAD4 R135* [cytosol]
(R-HSA-9675090)
SMAD4 L146* [cytosol]
(R-HSA-9678509)
SMAD4 L440* [cytosol]
(R-HSA-9678510)
SMAD4 Q183* [cytosol]
(R-HSA-9675176)
SMAD4 Q289* [cytosol]
(R-HSA-9675177)
SMAD4 Q248* [cytosol]
(R-HSA-9675178)
SMAD4 Q249* [cytosol]
(R-HSA-9675172)
SMAD4 Q256* [cytosol]
(R-HSA-9675173)
SMAD4 Q239* [cytosol]
(R-HSA-9675174)
SMAD4 Q245* [cytosol]
(R-HSA-9675175)
SMAD4 Q224* [cytosol]
(R-HSA-9675168)
SMAD4 W509* [cytosol]
(R-HSA-9678497)
SMAD4 Q311* [cytosol]
(R-HSA-9675169)
SMAD4 W398* [cytosol]
(R-HSA-9678498)
SMAD4 Q250* [cytosol]
(R-HSA-9675170)
SMAD4 Q410* [cytosol]
(R-HSA-9675196)
SMAD4 Q534* [cytosol]
(R-HSA-9675197)
SMAD4 Q83* [cytosol]
(R-HSA-9675199)
SMAD4 Q448* [cytosol]
(R-HSA-9675192)
SMAD4 K428R [cytosol]
(R-HSA-3311001)
SMAD4 Q455* [cytosol]
(R-HSA-9675193)
SMAD4 R445* [cytosol]
(R-HSA-9675065)
SMAD4 Q442* [cytosol]
(R-HSA-9675194)
SMAD4 Q516* [cytosol]
(R-HSA-9675195)
SMAD4 C443* [cytosol]
(R-HSA-9678523)
SMAD4 Q334* [cytosol]
(R-HSA-9675191)
SMAD4 R361G [cytosol]
(R-HSA-3310993)
SMAD4 L172* [cytosol]
(R-HSA-9678514)
SMAD4 K122* [cytosol]
(R-HSA-9678515)
SMAD4 R361S [cytosol]
(R-HSA-3310994)
SMAD4 Y430* [cytosol]
(R-HSA-9678476)
SMAD4 Y260* [cytosol]
(R-HSA-9678477)
SMAD4 Y95* [cytosol]
(R-HSA-9678478)
SMAD4 Y322* [cytosol]
(R-HSA-9678479)
SMAD4 E321* [cytosol]
(R-HSA-9675658)
SMAD4 Y412* [cytosol]
(R-HSA-9678469)
SMAD4 R515* [cytosol]
(R-HSA-3311012)
SMAD4 Y328* [cytosol]
(R-HSA-9678470)
SMAD4 E33* [cytosol]
(R-HSA-9675654)
SMAD4 Y513* [cytosol]
(R-HSA-9678471)
SMAD4 E526* [cytosol]
(R-HSA-9675648)
SMAD4 S138* [cytosol]
(R-HSA-9675649)
SMAD4 Y276* [cytosol]
(R-HSA-9678466)
SMAD4 E205* [cytosol]
(R-HSA-9675650)
SMAD4 E49* [cytosol]
(R-HSA-9675651)
SMAD4 W101* [cytosol]
(R-HSA-9678492)
SMAD4 W268* [cytosol]
(R-HSA-9678494)
SMAD4 [nucleoplasm]
(R-HSA-177103)
SMAD4 [cytosol]
(R-HSA-170862)
RibC-SMAD4 [nucleoplasm]
(R-HSA-2187323)
SMAD4 W524* [cytosol]
(R-HSA-9678491)
SMAD4 W302* [cytosol]
(R-HSA-9678490)
SMAD4 S242* [cytosol]
(R-HSA-9675167)
SMAD4 Q116* [cytosol]
(R-HSA-9675166)
0.946
12
UniProt:Q9HAU4 SMURF2
2
SMURF2 [cytosol]
(R-HSA-173537)
SMURF2 [nucleoplasm]
(R-HSA-178202)
0.811
6
UniProt:P17844 DDX5
4
DDX5 [cytosol]
(R-HSA-9682643)
DDX5 [nucleoplasm]
(R-HSA-3900136)
SUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
SUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.612
4
UniProt:P10275 AR
4
SUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.602
6
UniProt:Q9HCE7 SMURF1
2
SMURF1 [cytosol]
(R-HSA-975972)
SMURF1 [nucleoplasm]
(R-HSA-3004548)
0.573
2
UniProt:P49841 GSK3B
4
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [cytosol]
(R-HSA-2997551)
GSK3B [nucleoplasm]
(R-HSA-2022823)
0.571
2
UniProt:O43541 SMAD6
1
SMAD6 [cytosol]
(R-HSA-3006350)
0.567
4
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.556
3
UniProt:P46937 YAP1
7
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
0.544
3
UniProt:O15397 IPO8
2
IPO8 [cytosol]
(R-HSA-5578740)
IPO8 [nucleoplasm]
(R-HSA-5578747)
0.544
2
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