Reactome | Ub-SMAD1 [cytosol]

Ub-SMAD1 [cytosol]

Stable Identifier

R-HSA-6782768

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SMAD1, R-Smad1, Mothers against decapentaplegic homolog 1, SMA1_HUMAN

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
        
        Ub-SMAD1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15797 SMAD1

Gene Names

SMAD1, BSP1, MADH1, MADR1

Chain

chain:1-465

Reference Genes

BioGPS Gene:4086 SMAD1

COSMIC (genes):SMAD1 SMAD1

CTD Gene:4086 SMAD1

dbSNP Gene:4086 SMAD1

ENSEMBL:ENSG00000170365 SMAD1

HGNC:6767 SMAD1

KEGG Gene (Homo sapiens):4086 SMAD1

Monarch:4086 SMAD1

NCBI Gene:4086 SMAD1

OMIM:601595 SMAD1

UCSC:Q15797 SMAD1

Reference Transcript

Other Identifiers

11723044_at

11747501_a_at

1325_at

1KHU

210993_s_at

227798_at

2746118

2746120

2746121

2746122

2746123

2746124

2746125

2746126

2746127

2746130

2746131

2746138

2746141

2746142

2746144

2746147

2746150

2746151

2LAW

2LAX

2LAY

2LAZ

2LB0

2LB1

37280_at

3Q47

3Q4A

4086

50875_at

5389

5ZOK

8097657

A_14_P103768

A_23_P212870

A_24_P71938

AAB06852

AAC50493

AAC50621

AAC50790

AAH01878

AAP36050

AK293055

AL117396

BAF85744

BC001878

BT007386

CAB005389

CAB55898

CCDS3765

CH471056

D6RAY1

D6RBH9

D6RD62

D6RDN7

D6REQ3

EAX05037

EAX05038

EAX05039

EAX05040

ENSG00000170365

ENSP00000305769

ENSP00000377652

ENSP00000426568

ENST00000302085

ENST00000302085.8

ENST00000394092

ENST00000394092.6

ENST00000515385

ENST00000515385.1

EntrezGene:4086

EntrezGene:SMAD1

g1332713_3p_a_at

GE59266

GE84973

GO:0000003

GO:0000165

GO:0000978

GO:0000981

GO:0001228

GO:0001657

GO:0001710

GO:0002051

GO:0003674

GO:0003677

GO:0003700

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005637

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0006464

GO:0006468

GO:0006950

GO:0006954

GO:0007165

GO:0007179

GO:0007183

GO:0007276

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0009790

GO:0009880

GO:0010628

GO:0016021

GO:0016579

GO:0017151

GO:0019899

GO:0019901

GO:0022607

GO:0030154

GO:0030509

GO:0030618

GO:0030901

GO:0030902

GO:0031053

GO:0032991

GO:0034641

GO:0040007

GO:0042592

GO:0042802

GO:0042803

GO:0043167

GO:0043226

GO:0043565

GO:0045669

GO:0045944

GO:0046872

GO:0046982

GO:0048646

GO:0048856

GO:0051216

GO:0060038

GO:0060348

GO:0060395

GO:0061036

GO:0065003

GO:0070410

GO:0070411

GO:0070878

GO:0071141

GO:0071407

GO:0071773

GO:1901522

GO:1902895

GO:1903672

HGNC:6767

Hs.322710.0.A1_3p_at

ILMN_1670540

ILMN_1705392

IPR001132

IPR003619

IPR008984

IPR013019

IPR013790

IPR017855

IPR036578

MIM:601595

NM_001003688

NM_001354811

NM_001354812

NM_001354813

NM_001354814

NM_001354816

NM_001354817

NM_005900

NP_001003688

NP_001341740

NP_001341741

NP_001341742

NP_001341743

NP_001341745

NP_001341746

NP_005891

PF03165

PF03166

PH_hs_0024460

PH_hs_0032859

SM00523

SM00524

SMAD1

SMAD1-201

SMAD1-202

SMAD1-215

TC04000711.hg

U54826

U57456

U59423

U59423_at

U59912

UPI0000135A76

XM_011531962

XM_011531964

XP_011530264

XP_011530266

Participant Of

hasMember

Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol]

Other forms of this molecule

p-S463,S465-SMAD1 [nucleoplasm]

p-S463,S465-SMAD1 [cytosol]

SMAD1 [cytosol]

Inferred To

Ub-SMAD1 [cytosol] (Bos taurus)

Ub-SMAD1 [cytosol] (Canis familiaris)

Ub-SMAD1 [cytosol] (Danio rerio)

Ub-SMAD1 [cytosol] (Gallus gallus)

Ub-SMAD1 [cytosol] (Mus musculus)

Ub-SMAD1 [cytosol] (Rattus norvegicus)

Ub-SMAD1 [cytosol] (Sus scrofa)

Ub-SMAD1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_005263049.1, XP_006714280.1, XP_011530266.1, XP_011530264.1, NP_001003688.1, XP_011530265.1, XP_011530263.1, NP_005891.1

OpenTargets

ENSG00000170365

GeneCards

Q15797

PRO

Q15797

PDB

2LAW, 1KHU, 2LAY, 5ZOK, 2LB1, 3Q4A, 2LAZ, 2LAX, 3Q47, 2LB0

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	18	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R361C [cytosol] (R-HSA-3310983)	0.942	11
UniProt:Q9HAU4 SMURF2	2	SMURF2 [cytosol] (R-HSA-173537) SMURF2 [nucleoplasm] (R-HSA-178202)	0.791	5
UniProt:P17844 DDX5	3	SUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) DDX5 [nucleoplasm] (R-HSA-3900136) SUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.612	4
UniProt:P49841 GSK3B	4	p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.609	2
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.602	6
UniProt:Q9HCE7 SMURF1	2	SMURF1 [cytosol] (R-HSA-975972) SMURF1 [nucleoplasm] (R-HSA-3004548)	0.573	2
UniProt:O43541 SMAD6	1	SMAD6 [cytosol] (R-HSA-3006350)	0.567	4
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.544	3
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.544	2