Reactome | Ub-SMAD1 [cytosol]

Ub-SMAD1 [cytosol]

Stable Identifier

R-HSA-6782768

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SMAD1, R-Smad1, Mothers against decapentaplegic homolog 1, SMA1_HUMAN

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)
        
        Ub-SMAD1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15797 SMAD1

Gene Names

SMAD1, BSP1, MADH1, MADR1

Chain

chain:1-465

Reference Genes

BioGPS Gene:4086 SMAD1

COSMIC (genes):SMAD1 SMAD1

CTD Gene:4086 SMAD1

dbSNP Gene:4086 SMAD1

ENSEMBL:ENSG00000170365 SMAD1

HGNC:6767 SMAD1

KEGG Gene (Homo sapiens):4086 SMAD1

Monarch:4086 SMAD1

NCBI Gene:4086 SMAD1

OMIM:601595 SMAD1

UCSC:Q15797 SMAD1

Reference Transcript

Other Identifiers

11723044_at

11747501_a_at

1325_at

210993_s_at

227798_at

2746118

2746120

2746121

2746122

2746123

2746124

2746125

2746126

2746127

2746130

2746131

2746138

2746141

2746142

2746144

2746147

2746150

2746151

37280_at

4086

50875_at

8097657

A_14_P103768

A_23_P212870

A_24_P71938

GE59266

GE84973

GO:0000003

GO:0000165

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0001657

GO:0001710

GO:0002051

GO:0003674

GO:0003677

GO:0003700

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0006464

GO:0006468

GO:0006950

GO:0006954

GO:0007165

GO:0007179

GO:0007183

GO:0007276

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0009653

GO:0009790

GO:0009880

GO:0010628

GO:0016021

GO:0016579

GO:0017151

GO:0019899

GO:0019901

GO:0022607

GO:0030154

GO:0030509

GO:0030901

GO:0030902

GO:0031053

GO:0032991

GO:0034641

GO:0040007

GO:0042592

GO:0042802

GO:0043167

GO:0043226

GO:0043565

GO:0045669

GO:0045944

GO:0046872

GO:0048646

GO:0048856

GO:0051216

GO:0060038

GO:0060348

GO:0060395

GO:0061036

GO:0065003

GO:0070410

GO:0070411

GO:0070878

GO:0071141

GO:0071144

GO:0071407

GO:0071773

GO:1901522

GO:1902895

GO:1903672

HMNXSV003005904

Hs.322710.0.A1_3p_at

ILMN_1670540

ILMN_1705392

PH_hs_0024460

PH_hs_0032859

TC04000711.hg

U59423_at

g1332713_3p_a_at

Participates

as a member of

Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Homo sapiens)

Other forms of this molecule

SMAD1 [cytosol]

p-S463,S465-SMAD1 [cytosol]

p-S463,S465-SMAD1 [nucleoplasm]

Inferred To

smad1 [cytosol] (Danio rerio)

Smad1 [cytosol] (Mus musculus)

Smad1 [cytosol] (Rattus norvegicus)

sma-2 [cytosol] (Caenorhabditis elegans)

daf-14 [cytosol] (Caenorhabditis elegans)

Homologues of Ub-SMAD1 [cytosol] (Caenorhabditis elegans)

sma-3 [cytosol] (Caenorhabditis elegans)

SMAD1 [cytosol] (Canis familiaris)

SMAD1 [cytosol] (Gallus gallus)

SMAD1 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_005263049.1, XP_011530264.1, XP_011530266.1, XP_011530265.1, XP_006714280.1, NP_005891.1, NP_001003688.1, XP_011530263.1

OpenTargets

ENSG00000170365

HPA

ENSG00000170365-SMAD1

GeneCards

Q15797

Ensembl

ENST00000394092, ENST00000302085, ENSP00000426568, ENSG00000170365, ENSP00000305769, ENST00000515385, ENSP00000377652

PRO

Q15797

PDB

3Q4A, 5ZOK, 2LAY, 3Q47, 2LB1, 2LB0, 2LAZ, 2LAX, 2LAW, 1KHU

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	88	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622) SMAD4 E417* [cytosol] (R-HSA-9675623) SMAD4 Y195* [cytosol] (R-HSA-9678462) SMAD4 E108* [cytosol] (R-HSA-9675640) SMAD4 S343* [cytosol] (R-HSA-9675641) SMAD4 E520* [cytosol] (R-HSA-9675636) SMAD4 G510* [cytosol] (R-HSA-9678452) SMAD4 G358* [cytosol] (R-HSA-9678453) SMAD4 E175* [cytosol] (R-HSA-9675637) SMAD4 E307* [cytosol] (R-HSA-9675639) SMAD4 E53* [cytosol] (R-HSA-9675633) SMAD4 S171* [cytosol] (R-HSA-9675634) SMAD4 G30* [cytosol] (R-HSA-9678450) SMAD4 G168* [cytosol] (R-HSA-9678451) SMAD4 Q366* [cytosol] (R-HSA-9675200) SMAD4 R135* [cytosol] (R-HSA-9675090) SMAD4 L146* [cytosol] (R-HSA-9678509) SMAD4 L440* [cytosol] (R-HSA-9678510) SMAD4 Q183* [cytosol] (R-HSA-9675176) SMAD4 Q289* [cytosol] (R-HSA-9675177) SMAD4 Q248* [cytosol] (R-HSA-9675178) SMAD4 Q249* [cytosol] (R-HSA-9675172) SMAD4 Q256* [cytosol] (R-HSA-9675173) SMAD4 Q239* [cytosol] (R-HSA-9675174) SMAD4 Q245* [cytosol] (R-HSA-9675175) SMAD4 Q224* [cytosol] (R-HSA-9675168) SMAD4 W509* [cytosol] (R-HSA-9678497) SMAD4 Q311* [cytosol] (R-HSA-9675169) SMAD4 W398* [cytosol] (R-HSA-9678498) SMAD4 Q250* [cytosol] (R-HSA-9675170) SMAD4 Q410* [cytosol] (R-HSA-9675196) SMAD4 Q534* [cytosol] (R-HSA-9675197) SMAD4 Q83* [cytosol] (R-HSA-9675199) SMAD4 Q448* [cytosol] (R-HSA-9675192) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 Q455* [cytosol] (R-HSA-9675193) SMAD4 R445* [cytosol] (R-HSA-9675065) SMAD4 Q442* [cytosol] (R-HSA-9675194) SMAD4 Q516* [cytosol] (R-HSA-9675195) SMAD4 C443* [cytosol] (R-HSA-9678523) SMAD4 Q334* [cytosol] (R-HSA-9675191) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 L172* [cytosol] (R-HSA-9678514) SMAD4 K122* [cytosol] (R-HSA-9678515) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 Y430* [cytosol] (R-HSA-9678476) SMAD4 Y260* [cytosol] (R-HSA-9678477) SMAD4 Y95* [cytosol] (R-HSA-9678478) SMAD4 Y322* [cytosol] (R-HSA-9678479) SMAD4 E321* [cytosol] (R-HSA-9675658) SMAD4 Y412* [cytosol] (R-HSA-9678469) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 Y328* [cytosol] (R-HSA-9678470) SMAD4 E33* [cytosol] (R-HSA-9675654) SMAD4 Y513* [cytosol] (R-HSA-9678471) SMAD4 E526* [cytosol] (R-HSA-9675648) SMAD4 S138* [cytosol] (R-HSA-9675649) SMAD4 Y276* [cytosol] (R-HSA-9678466) SMAD4 E205* [cytosol] (R-HSA-9675650) SMAD4 E49* [cytosol] (R-HSA-9675651) SMAD4 W101* [cytosol] (R-HSA-9678492) SMAD4 W268* [cytosol] (R-HSA-9678494) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 W524* [cytosol] (R-HSA-9678491) SMAD4 W302* [cytosol] (R-HSA-9678490) SMAD4 S242* [cytosol] (R-HSA-9675167) SMAD4 Q116* [cytosol] (R-HSA-9675166)	0.946	12
UniProt:Q9HAU4 SMURF2	2	SMURF2 [cytosol] (R-HSA-173537) SMURF2 [nucleoplasm] (R-HSA-178202)	0.811	6
UniProt:P17844 DDX5	4	DDX5 [cytosol] (R-HSA-9682643) DDX5 [nucleoplasm] (R-HSA-3900136) SUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) SUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.612	4
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.602	6
UniProt:Q9HCE7 SMURF1	2	SMURF1 [cytosol] (R-HSA-975972) SMURF1 [nucleoplasm] (R-HSA-3004548)	0.573	2
UniProt:P49841 GSK3B	4	p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.571	2
UniProt:O43541 SMAD6	1	SMAD6 [cytosol] (R-HSA-3006350)	0.567	4
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.556	3
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.544	3
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.544	2

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