Reactome | Ub-STAM2 [cytosol]

Ub-STAM2 [cytosol]

Stable Identifier

R-HSA-6782781

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal transducing adapter molecule 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75886 STAM2

Gene Names

STAM2, HBP

Chain

chain:1-525

Reference Genes

BioGPS Gene:10254 STAM2

COSMIC (genes):STAM2 STAM2

CTD Gene:10254 STAM2

dbSNP Gene:10254 STAM2

ENSEMBL:ENSG00000115145 STAM2

HGNC:11358 STAM2

KEGG Gene (Homo sapiens):10254 STAM2

Monarch:10254 STAM2

NCBI Gene:10254 STAM2

OMIM:606244 STAM2

UCSC:O75886 STAM2

Reference Transcript

RefSeq:NM_005843.5 STAM2

Other Identifiers

10254

11731592_at

11731593_a_at

11731594_at

11731595_x_at

16903794

208194_s_at

209649_at

215044_s_at

228254_3p_at

228254_at

242569_at

2581431

2581432

2581433

2581434

2581435

2581436

2581438

2581440

2581443

2581445

2581446

2581447

2581450

2581451

2581452

2581453

2581454

2581455

2581456

2581458

2581459

38525_at

50573_r_at

60468_at

8055890

A_23_P209215

A_24_P62860

GE535132

GE56632

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0006464

GO:0006810

GO:0006886

GO:0006914

GO:0007165

GO:0008150

GO:0009056

GO:0015031

GO:0016020

GO:0016192

GO:0016197

GO:0016236

GO:0016579

GO:0022607

GO:0030139

GO:0031410

GO:0031901

GO:0032991

GO:0033565

GO:0036258

GO:0042059

GO:0043226

GO:0043231

GO:0061024

Hs.114624.0.A1_3p_at

Hs.114624.0.A1_3p_x_at

Hs.123778.0.A1_3p_at

Hs.306650.0.S1_3p_s_at

ILMN_1781135

PH_hs_0027585

TC02002432.hg

g5032126_3p_a_at

g6599205_3p_at

Participant Of

hasComponent

USP8:Ub-STAM2:HGS [cytosol]

Other forms of this molecule

STAM2 [cytosol]

Inferred To

Ub-STAM2 [cytosol] (Gallus gallus)

Stam [cytosol] (Drosophila melanogaster)

STAM2 [cytosol] (Canis familiaris)

STAM2 [cytosol] (Sus scrofa)

Stam2 [cytosol] (Mus musculus)

Stam2 [cytosol] (Rattus norvegicus)

stam2 [cytosol] (Danio rerio)

stam2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_005834.4

OpenTargets

ENSG00000115145

HPA

ENSG00000115145-STAM2

GeneCards

O75886

Ensembl

ENSG00000115145, ENSP00000263904, ENST00000263904

PRO

O75886

PDB

5IXF, 1X2Q, 2L0T, 5CRV, 1X5B

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.788	9
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.778	5
UniProt:Q969R5 L3MBTL2	2	SUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480) L3MBTL2 [nucleoplasm] (R-HSA-6804477)	0.666	4
UniProt:O00311 CDC7	1	CDC7 [nucleoplasm] (R-HSA-51781)	0.556	3
UniProt:P23458 JAK1	6	JAK1 [endosome] (R-HSA-8983168) p-Y1022,Y1023-JAK1 [cytosol] (R-HSA-9005335) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921) p-Y1034-JAK1 [cytosol] (R-HSA-1112543)	0.502	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.463	2

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