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Ub-STAM2 [cytosol]
Stable Identifier
R-HSA-6782781
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Signal transducing adapter molecule 2
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP8 deubiquitinates STAM2:HGS (Homo sapiens)
USP8:Ub-STAM2:HGS [cytosol] (Homo sapiens)
Ub-STAM2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75886 STAM2
Gene Names
STAM2, HBP
Chain
chain:1-525
Reference Genes
BioGPS Gene:10254 STAM2
COSMIC (genes):STAM2 STAM2
CTD Gene:10254 STAM2
dbSNP Gene:10254 STAM2
ENSEMBL:ENSG00000115145 STAM2
HGNC:11358 STAM2
KEGG Gene (Homo sapiens):10254 STAM2
Monarch:10254 STAM2
NCBI Gene:10254 STAM2
OMIM:606244 STAM2
UCSC:O75886 STAM2
Reference Transcript
RefSeq:NM_005843.5 STAM2
Other Identifiers
10254
11731592_at
11731593_a_at
11731594_at
11731595_x_at
16903794
208194_s_at
209649_at
215044_s_at
228254_3p_at
228254_at
242569_at
2581431
2581432
2581433
2581434
2581435
2581436
2581438
2581440
2581443
2581445
2581446
2581447
2581450
2581451
2581452
2581453
2581454
2581455
2581456
2581458
2581459
38525_at
50573_r_at
60468_at
8055890
A_23_P209215
A_24_P62860
GE535132
GE56632
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0006464
GO:0006810
GO:0006886
GO:0006914
GO:0007165
GO:0008150
GO:0009056
GO:0015031
GO:0016020
GO:0016192
GO:0016197
GO:0016236
GO:0016579
GO:0022607
GO:0030139
GO:0031410
GO:0031901
GO:0032991
GO:0033565
GO:0036258
GO:0042059
GO:0043226
GO:0043231
GO:0061024
Hs.114624.0.A1_3p_at
Hs.114624.0.A1_3p_x_at
Hs.123778.0.A1_3p_at
Hs.306650.0.S1_3p_s_at
ILMN_1781135
PH_hs_0027585
TC02002432.hg
g5032126_3p_a_at
g6599205_3p_at
Participant Of
hasComponent
USP8:Ub-STAM2:HGS [cytosol]
Other forms of this molecule
STAM2 [cytosol]
Inferred To
Ub-STAM2 [cytosol] (Gallus gallus)
Stam [cytosol] (Drosophila melanogaster)
STAM2 [cytosol] (Canis familiaris)
STAM2 [cytosol] (Sus scrofa)
Stam2 [cytosol] (Mus musculus)
Stam2 [cytosol] (Rattus norvegicus)
stam2 [cytosol] (Danio rerio)
stam2 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_005834.4
OpenTargets
ENSG00000115145
HPA
ENSG00000115145-STAM2
GeneCards
O75886
Ensembl
ENSP00000263904
,
ENST00000263904
,
ENSG00000115145
PRO
O75886
PDB
2L0T
,
1X5B
,
5CRV
,
1X2Q
,
5IXF
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.839
9
UniProt:Q13094 LCP2
2
LCP2 [cytosol]
(R-HSA-202306)
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
0.788
9
UniProt:Q969R5 L3MBTL2
2
SUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:P0CG47 UBB
109
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-110-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-186-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-182-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
Ub-106-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783103)
Ub-27-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783038)
Ub-180-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783114)
Ub-104-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783149)
N6-glycyl-L-lysine-UBB(1-76) [cytosol]
(R-HSA-8869049)
N6-glycyl-L-lysine-UBB(153-228) [cytosol]
(R-HSA-8869046)
N6-glycyl-L-lysine-UBB(77-152) [cytosol]
(R-HSA-8869047)
adenylatedG152-UBB(77-152) [nucleoplasm]
(R-HSA-8852094)
adenylatedG228-UBB(153-228) [nucleoplasm]
(R-HSA-8852104)
adenylatedG76-UBB(1-76) [nucleoplasm]
(R-HSA-8852101)
UBB [cytosol]
(R-HSA-8853516)
adenylatedG76-UBB(1-76) [cytosol]
(R-HSA-8852121)
adenylatedG228-UBB(153-228) [cytosol]
(R-HSA-8852049)
adenylatedG152-UBB(77-152) [cytosol]
(R-HSA-8852113)
Ub-124-UBB(77-152) [endoplasmic reticulum membrane]
(R-HSA-8943100)
Ub-48-UBB(1-76) [endoplasmic reticulum membrane]
(R-HSA-8943138)
Ub-200-UBB(153-228) [endoplasmic reticulum membrane]
(R-HSA-8943117)
UBB(153-228) [plasma membrane]
(R-HSA-3149455)
UBB(1-76) [plasma membrane]
(R-HSA-3149453)
UBB(77-152) [plasma membrane]
(R-HSA-3149463)
UBB(77-152) [endosome membrane]
(R-HSA-939251)
UBB(1-76) [endosome membrane]
(R-HSA-939240)
UBB(153-228) [endosome membrane]
(R-HSA-939247)
UBB(153-228) [endoplasmic reticulum membrane]
(R-HSA-8943098)
UBB(77-152) [endoplasmic reticulum membrane]
(R-HSA-8943111)
UBB(1-76) [endoplasmic reticulum membrane]
(R-HSA-8943078)
Ub-106-UBB(77-152) [cytosol]
(R-HSA-5689191)
Ub-182-UBB(153-228) [cytosol]
(R-HSA-5689214)
Ub-29-UBB(1-76) [cytosol]
(R-HSA-5689207)
Ub-158-UBB(153-228) [cytosol]
(R-HSA-5689099)
Ub-82-UBB(77-152) [cytosol]
(R-HSA-5689080)
Ub-6-UBB(1-76) [cytosol]
(R-HSA-5689075)
Ub-33-UBB(1-76) [cytosol]
(R-HSA-5689198)
Ub-186-UBB(153-228) [cytosol]
(R-HSA-5689146)
Ub-110-UBB(77-152) [cytosol]
(R-HSA-5689203)
Ub-27-UBB(1-76) [cytosol]
(R-HSA-5689161)
Ub-104-UBB(77-152) [cytosol]
(R-HSA-5689139)
Ub-180-UBB(153-228) [cytosol]
(R-HSA-5689138)
Ub-11-UBB(1-76) [cytosol]
(R-HSA-3095929)
Ub-163-UBB(153-228) [cytosol]
(R-HSA-3095932)
Ub-87-UBB(77-152) [cytosol]
(R-HSA-3095917)
Ub-139-UBB(77-152) [endosome membrane]
(R-HSA-939217)
Ub-215-UBB(153-228) [endosome membrane]
(R-HSA-939193)
Ub-63-UBB(1-76) [endosome membrane]
(R-HSA-939167)
Ub-139-UBB(77-152) [plasma membrane]
(R-HSA-939867)
Ub-63-UBB(1-76) [plasma membrane]
(R-HSA-939872)
Ub-215-UBB(153-228) [plasma membrane]
(R-HSA-939852)
Ub-27-UBB(1-76) [nucleoplasm]
(R-HSA-6782673)
Ub-180-UBB(153-228) [nucleoplasm]
(R-HSA-6782604)
Ub-104-UBB(77-152) [nucleoplasm]
(R-HSA-6782627)
Ub-106-UBB(77-152) [nucleoplasm]
(R-HSA-6782652)
Ub-182-UBB(153-228) [nucleoplasm]
(R-HSA-6782665)
Ub-29-UBB(1-76) [nucleoplasm]
(R-HSA-6782595)
Ub-124-UBB(77-152) [nucleoplasm]
(R-HSA-6782527)
Ub-48-UBB(1-76) [nucleoplasm]
(R-HSA-6782505)
Ub-200-UBB(153-228) [nucleoplasm]
(R-HSA-6782478)
Ub-11-UBB(1-76) [nucleoplasm]
(R-HSA-6782649)
Ub-87-UBB(77-152) [nucleoplasm]
(R-HSA-6782607)
Ub-163-UBB(153-228) [nucleoplasm]
(R-HSA-6782598)
Ub-186-UBB(153-228) [nucleoplasm]
(R-HSA-6782655)
Ub-110-UBB(77-152) [nucleoplasm]
(R-HSA-6782591)
Ub-33-UBB(1-76) [nucleoplasm]
(R-HSA-6782601)
UBB(77-152) [nucleoplasm]
(R-HSA-939870)
UBB(1-76) [nucleoplasm]
(R-HSA-939847)
UBB(153-228) [nucleoplasm]
(R-HSA-939854)
Ub-48-UBB(1-76) [nucleoplasm]
(R-HSA-5683040)
Ub-124-UBB(77-152) [nucleoplasm]
(R-HSA-5683036)
Ub-200-UBB(153-228) [nucleoplasm]
(R-HSA-5683038)
Ub-139-UBB(77-152) [nucleoplasm]
(R-HSA-6782488)
Ub-63-UBB(1-76) [nucleoplasm]
(R-HSA-6782489)
Ub-215-UBB(153-228) [nucleoplasm]
(R-HSA-6782475)
Ub-82-UBB(77-152) [nucleoplasm]
(R-HSA-6782683)
Ub-6-UBB(1-76) [nucleoplasm]
(R-HSA-6782600)
Ub-158-UBB(153-228) [nucleoplasm]
(R-HSA-6782639)
UBB(153-228) [late endosome lumen]
(R-HSA-9660014)
UBB(77-152) [late endosome lumen]
(R-HSA-9660021)
UBB(1-76) [late endosome lumen]
(R-HSA-9660017)
Ub-48-UBB(1-76) [cytosol]
(R-HSA-939249)
Ub-124-UBB(77-152) [cytosol]
(R-HSA-939225)
Ub-200-UBB(153-228) [cytosol]
(R-HSA-939197)
UBB(153-228) [cytosol]
(R-HSA-939230)
UBB(77-152) [cytosol]
(R-HSA-939213)
UBB(1-76) [cytosol]
(R-HSA-939214)
UBB(77-152) [lysosomal lumen]
(R-HSA-9660011)
UBB(1-76) [lysosomal lumen]
(R-HSA-9660024)
UBB(153-228) [lysosomal lumen]
(R-HSA-9660025)
Ub-63-UBB(1-76) [cytosol]
(R-HSA-939224)
Ub-215-UBB(153-228) [cytosol]
(R-HSA-939168)
Ub-139-UBB(77-152) [cytosol]
(R-HSA-939235)
0.556
3
UniProt:O00311 CDC7
1
CDC7 [nucleoplasm]
(R-HSA-51781)
0.556
3
UniProt:P02545 LMNA
3
LMNA-RAF1 fusion [cytosol]
(R-HSA-6802399)
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
p-LMNA-RAF1 fusion [cytosol]
(R-HSA-6802537)
0.556
3
UniProt:O76024 WFS1
3
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P23458 JAK1
6
JAK1 [endosome]
(R-HSA-8983168)
p-Y1022,Y1023-JAK1 [cytosol]
(R-HSA-9005335)
p-JAK1 [cytosol]
(R-HSA-8950711)
JAK1 [cytosol]
(R-HSA-451898)
p-Y-JAK1 [cytosol]
(R-HSA-451921)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
0.502
2
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.463
2
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