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PolyUb-CDC25A [cytosol]
Stable Identifier
R-HSA-6782810
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CDC25A, Cdc25A
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
PolyUb-CDC25A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30304 CDC25A
Gene Names
CDC25A
Chain
chain:1-524
Reference Genes
BioGPS Gene:993 CDC25A
COSMIC (genes):CDC25A CDC25A
CTD Gene:993 CDC25A
dbSNP Gene:993 CDC25A
ENSEMBL:ENSG00000164045 CDC25A
ENSEMBL_homo_sapiens_GENE:ENSG00000164045.12 CDC25A
HGNC:1725 CDC25A
KEGG Gene (Homo sapiens):993 CDC25A
Monarch:993 CDC25A
NCBI Gene:993 CDC25A
OMIM:116947 CDC25A
UCSC:P30304 CDC25A
Reference Transcript
RefSeq:NM_201567.1 CDC25A
RefSeq:NM_001789.2 CDC25A
RefSeq:XM_011534316.1 CDC25A
Other Identifiers
11726756_a_at
11726757_s_at
11726758_a_at
1555772_PM_a_at
1555772_a_at
16953279
1738_at
204695_PM_at
204695_at
204696_PM_s_at
204696_s_at
2673086
2673087
2673088
2673089
2673091
2673092
2673093
2673094
2673096
2673097
2673098
2673100
2673102
2673104
2673105
2673106
2673107
2673108
35407_at
54538_at
8086880
993
A_23_P121423
A_24_P397107
GE58099
GO:0000079
GO:0000082
GO:0000086
GO:0000278
GO:0003824
GO:0004721
GO:0004725
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006260
GO:0006470
GO:0007049
GO:0008283
GO:0009314
GO:0010971
GO:0016787
GO:0019901
GO:0022414
GO:0034644
GO:0036211
GO:0043226
GO:0045740
GO:0051087
GO:0051301
GO:0110032
GO:0140096
GO:1902751
HMNXSV003034851
HMNXSV003053919
Hs.1634.0.S2_3p_at
Hs2.1634.2.S1_3p_s_at
ILMN_1711005
ILMN_1733396
M81933_at
PH_hs_0000223
TC03001374.hg
g4502704_3p_a_at
Participates
as a member of
PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
Other forms of this molecule
CDC25A [nucleoplasm]
CDC25A [cytosol]
p-S124-CDC25A [nucleoplasm]
p-S124-CDC25A [cytosol]
p-S40,S116,S261-CDC25A [nucleoplasm]
Inferred To
cdc25a [cytosol]
(Xenopus tropicalis)
cdc25 [cytosol]
(Dictyostelium discoideum)
cdc25 [cytosol]
(Schizosaccharomyces pombe)
twe [cytosol]
(Drosophila melanogaster)
MIH1 [cytosol]
(Saccharomyces cerevisiae)
cdc-25.1 [cytosol]
(Caenorhabditis elegans)
CDC25A [cytosol]
(Bos taurus)
CDC25A [cytosol]
(Canis familiaris)
CDC25A [cytosol]
(Sus scrofa)
cdc25b [cytosol]
(Xenopus tropicalis)
Cdc25a [cytosol]
(Mus musculus)
Cdc25a [cytosol]
(Rattus norvegicus)
cdc-25.4 [cytosol]
(Caenorhabditis elegans)
cdc-25.3 [cytosol]
(Caenorhabditis elegans)
stg [cytosol]
(Drosophila melanogaster)
Homologues of PolyUb-CDC25A [cytosol]
(Caenorhabditis elegans)
Homologues of PolyUb-CDC25A [cytosol]
(Drosophila melanogaster)
Homologues of PolyUb-CDC25A [cytosol]
(Xenopus tropicalis)
cdc-25.2 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [cytosol]) at unknown position
Modification
PolyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_011532618.1
,
NP_963861.1
,
NP_001780.2
ZINC - World Drugs
MPIP1_HUMAN
OpenTargets
ENSG00000164045
ZINC - FDA approved
MPIP1_HUMAN
ZINC - Substances
MPIP1_HUMAN
ZINC - Biogenic
MPIP1_HUMAN
ZINC target
P30304
PRO
P30304
PDB
1C25
ZINC - Metabolites
MPIP1_HUMAN
IntEnz
3.1.3.48
GeneCards
P30304
HPA
ENSG00000164045-CDC25A
Ensembl
ENSP00000303706
,
ENSP00000343166
,
ENST00000351231
,
ENST00000302506
,
ENSG00000164045
Pharos - Targets
P30304
ZINC - Predictions - Purchasable
MPIP1_HUMAN
HMDB Protein
HMDBP08919
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.817
8
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.816
7
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.76
6
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.701
10
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.671
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.656
3
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
0.623
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.569
3
UniProt:Q9BSU3 NAA11
0.556
3
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