TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-HSA-6782893
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasm
ReviewStatus
5/5
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TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)
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As inferred from homologs in Saccharomyces cerevisiae, TRM12 transfers an aminocarboxypropyl group from S-adenosymethionine to yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe), yielding yW-86 (7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine) and S-methyl-5'-thioadenosine.
Literature References
PubMed ID Title Journal Year
22761755 Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA

Rodriguez, V, Vasudevan, S, Noma, A, Carlson, BA, Green, JE, Suzuki, T, Chandrasekharappa, SC

PLoS ONE 2012
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

transferase activity, transferring alkyl or aryl (other than methyl) groups of TRMT12 [cytoplasm]

Physical Entity
TRMT12 [cytoplasm] (Homo sapiens)
Activity
transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765)
Inferred From
TRM12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-08)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-09)
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