Reactome | K63polyUb-USP10 [cytosol]

K63polyUb-USP10 [cytosol]

Stable Identifier

R-HSA-6782986

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

USP10, Ubiquitin carboxyl-terminal hydrolase 10, Deubiquitinating enzyme 10, Ubiquitin thioesterase 10, Ubiquitin-specific-processing protease 10, KIAA0190

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP13 deubiquitinates BECN1,USP10 (Homo sapiens)
        
        USP13:K63polyUb-BECN1,K63polyUb-USP10 [cytosol] (Homo sapiens)
        
        K63polyUb-BECN1,K63polyUb-USP10 [cytosol] (Homo sapiens)
        
        K63polyUb-USP10 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14694 USP10

Gene Names

USP10, KIAA0190

Chain

initiator methionine:, chain:2-798

Reference Genes

BioGPS Gene:9100 USP10

COSMIC (genes):USP10 USP10

CTD Gene:9100 USP10

dbSNP Gene:9100 USP10

ENSEMBL:ENSG00000103194 USP10

ENSEMBL_homo_sapiens_GENE:ENSG00000103194.16 USP10

HGNC:12608 USP10

KEGG Gene (Homo sapiens):9100 USP10

Monarch:9100 USP10

NCBI Gene:9100 USP10

OMIM:609818 USP10

UCSC:Q14694 USP10

Reference Transcript

Other Identifiers

11732118_a_at

11732119_a_at

11747824_a_at

16821519

209136_PM_s_at

209136_s_at

209137_PM_s_at

209137_s_at

3527120

3527121

3527128

3527129

3527131

3527133

3527135

3527139

3527141

3527143

3527147

3527149

3527153

3671874

3671875

3671887

3671888

3671890

3671901

3671904

3671905

3671906

3671908

3671911

3671914

3671916

3671917

3671919

3671920

3671921

37683_at

3935735

3935736

3935737

3935738

3935740

3935743

3935744

3935745

3935747

3935750

3935751

3935753

3935754

3935757

7997633

9100

A_23_P100196

D80012_at

GE56867

GO:0002039

GO:0003723

GO:0003824

GO:0004197

GO:0004843

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005840

GO:0005856

GO:0006281

GO:0006508

GO:0006914

GO:0006974

GO:0008233

GO:0008234

GO:0010506

GO:0016579

GO:0016787

GO:0019985

GO:0022626

GO:0023052

GO:0030330

GO:0031410

GO:0032991

GO:0035520

GO:0036211

GO:0043124

GO:0043226

GO:0044325

GO:0045111

GO:0062030

GO:0071347

GO:0072344

GO:0098772

GO:0140096

GO:0140678

HMNXSV003037632

Hs.78829.0.A1_3p_a_at

ILMN_1721116

PH_hs_0027697

PH_hs_0031346

TC16000659.hg

g12653004_3p_a_at

Participates

as a member of

K63polyUb-BECN1,K63polyUb-USP10 [cytosol] (Homo sapiens)

Other forms of this molecule

USP10 [nucleoplasm]

USP10 [cytosol]

Inferred To

ubp3 [cytosol] (Schizosaccharomyces pombe)

K63polyUb-USP10 [cytosol] (Gallus gallus)

Usp10 [cytosol] (Mus musculus)

Usp10 [cytosol] (Rattus norvegicus)

USP10 [cytosol] (Canis familiaris)

USP10 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_005144.2, NP_001259004.1

OpenTargets

ENSG00000103194

ZINC - Substances

UBP10_HUMAN

ZINC target

Q14694

PRO

Q14694

PDB

8TH6, 7XHF

IntEnz

3.4.19.12

GeneCards

Q14694

HPA

ENSG00000103194-USP10

Ensembl

ENST00000570191, ENSP00000219473, ENSG00000103194, ENST00000219473, ENSP00000457411

Pharos - Targets

Q14694

ZINC - Predictions - Purchasable

UBP10_HUMAN

HMDB Protein

HMDBP10135

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.941	16
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.936	13
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.666	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.665	7
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.564	2
UniProt:Q5D1E8 ZC3H12A	1	ZC3H12A [nucleoplasm] (R-HSA-9774235)	0.558	5
UniProt:Q9UN86-2 G3BP2			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	2
UniProt:O75821 EIF3G	1	EIF3G [cytosol] (R-HSA-72538)	0.483	2
UniProt:O15084 ANKRD28	2	ANKRD28 [cytosol] (R-HSA-5685714) ANKRD28 [nucleoplasm] (R-HSA-9686571)	0.483	3
UniProt:Q9UPN7 PPP6R1	1	PPP6R1 [cytosol] (R-HSA-5685721)	0.483	2

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