Reactome | Ub-139-UBB(77-152) [mitochondrial outer membrane]

Ub-139-UBB(77-152) [mitochondrial outer membrane]

Stable Identifier

R-HSA-6783012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

K63 ubiquitin (UBB 2)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P0CG47 UBB

Gene Names

UBB

Chain

chain:1-76, chain:77-152, chain:153-228, propeptide:-

Reference Genes

BioGPS Gene:7314 UBB

COSMIC (genes):UBB UBB

CTD Gene:7314 UBB

dbSNP Gene:7314 UBB

ENSEMBL:ENSG00000170315 UBB

HGNC:12463 UBB

KEGG:hsa:7314 UBB

Monarch:7314 UBB

NCBI Gene:7314 UBB

OMIM:191339 UBB

UCSC:P0CG47 UBB

Reference Transcript

Other Identifiers

11732126_x_at

11744327_x_at

1323_at

16831434

200633_PM_at

200633_at

2578171

2578172

2578173

2578174

32153_s_at

3712044

3712045

3712046

3712047

3712048

3712050

3712051

3712052

3712053

3712054

3712055

3712056

3714880

3714882

3714883

3714884

3714885

3714889

7314

8005166

A_14_P126655

A_23_P27215

A_24_P113109

GE79998

GO:0005515

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005789

GO:0005829

GO:0005886

GO:0007018

GO:0007141

GO:0007144

GO:0008584

GO:0008585

GO:0010008

GO:0016567

GO:0019941

GO:0021888

GO:0022414

GO:0030666

GO:0031386

GO:0031398

GO:0031625

GO:0031982

GO:0043005

GO:0043025

GO:0043226

GO:0043229

GO:0043523

GO:0047497

GO:0048812

GO:0048856

GO:0051881

GO:0060612

GO:0060613

GO:0061136

GO:0070062

GO:0072520

GO:0097009

GO:0140013

GO:1902255

GO:1902527

HMNXSV003053727

ILMN_1762436

ILMN_2191428

PH_hs_0017263

TC17000187.hg

U49869_rna1_at

g11024713_3p_at

Participates

as a member of

K63-Ub [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

UBB(77-152) [endocytic vesicle membrane]

UBB(1-76) [endocytic vesicle membrane]

UBB(153-228) [endocytic vesicle membrane]

Ub-33-UBB(1-76) [mitochondrial outer membrane]

Ub-109-UBB(77-152) [mitochondrial outer membrane]

Ub-185-UBB(153-228) [mitochondrial outer membrane]

Ub-215-UBB(153-228) [mitochondrial outer membrane]

Ub-63-UBB(1-76) [mitochondrial outer membrane]

Ub-158-UBB(153-228) [mitochondrial outer membrane]

Ub-6-UBB(1-76) [mitochondrial outer membrane]

Ub-82-UBB(77-152) [mitochondrial outer membrane]

Ub-163-UBB(153-228) [mitochondrial outer membrane]

Ub-87-UBB(77-152) [mitochondrial outer membrane]

Ub-11-UBB(1-76) [mitochondrial outer membrane]

Ub-124-UBB(77-152) [mitochondrial outer membrane]

Ub-200-UBB(153-228) [mitochondrial outer membrane]

Ub-48-UBB(1-76) [mitochondrial outer membrane]

Ub-181-UBB(153-228) [mitochondrial outer membrane]

Ub-29-UBB(1-76) [mitochondrial outer membrane]

Ub-105-UBB(77-152) [mitochondrial outer membrane]

Ub-27-UBB(1-76) [mitochondrial outer membrane]

Ub-179-UBB(153-228) [mitochondrial outer membrane]

Ub-103-UBB(77-152) [mitochondrial outer membrane]

N6-glycyl-L-lysine-UBB(1-76) [cytosol]

N6-glycyl-L-lysine-UBB(153-228) [cytosol]

N6-glycyl-L-lysine-UBB(77-152) [cytosol]

adenylatedG152-UBB(77-152) [nucleoplasm]

adenylatedG228-UBB(153-228) [nucleoplasm]

adenylatedG76-UBB(1-76) [nucleoplasm]

UBB [cytosol]

adenylatedG76-UBB(1-76) [cytosol]

adenylatedG228-UBB(153-228) [cytosol]

adenylatedG152-UBB(77-152) [cytosol]

Ub-124-UBB(77-152) [endoplasmic reticulum membrane]

Ub-48-UBB(1-76) [endoplasmic reticulum membrane]

Ub-200-UBB(153-228) [endoplasmic reticulum membrane]

Ub-48-UBB(1-76) [lysosomal membrane]

Ub-124-UBB(77-152) [lysosomal membrane]

Ub-200-UBB(153-228) [lysosomal membrane]

Ub-48-UBB(1-76) [endocytic vesicle membrane]

Ub-200-UBB(153-228) [endocytic vesicle membrane]

Ub-124-UBB(77-152) [endocytic vesicle membrane]

UBB(77-152) [endosome membrane]

UBB(1-76) [endosome membrane]

UBB(153-228) [endosome membrane]

UBB(153-228) [plasma membrane]

UBB(1-76) [plasma membrane]

UBB(77-152) [plasma membrane]

Ub-105-UBB(77-152) [cytosol]

Ub-181-UBB(153-228) [cytosol]

Ub-29-UBB(1-76) [cytosol]

Ub-158-UBB(153-228) [cytosol]

Ub-82-UBB(77-152) [cytosol]

Ub-6-UBB(1-76) [cytosol]

Ub-27-UBB(1-76) [cytosol]

Ub-103-UBB(77-152) [cytosol]

Ub-179-UBB(153-228) [cytosol]

Ub-33-UBB(1-76) [cytosol]

Ub-185-UBB(153-228) [cytosol]

Ub-109-UBB(77-152) [cytosol]

M1-UBB(153-228) [cytosol]

M1-UBB(1-76) [cytosol]

M1-UBB(77-152) [cytosol]

UBB(153-228) [endoplasmic reticulum membrane]

UBB(77-152) [endoplasmic reticulum membrane]

UBB(1-76) [endoplasmic reticulum membrane]

Ub-27-UBB(1-76) [nucleoplasm]

Ub-179-UBB(153-228) [nucleoplasm]

Ub-103-UBB(77-152) [nucleoplasm]

Ub-105-UBB(77-152) [nucleoplasm]

Ub-181-UBB(153-228) [nucleoplasm]

Ub-29-UBB(1-76) [nucleoplasm]

Ub-185-UBB(153-228) [nucleoplasm]

Ub-109-UBB(77-152) [nucleoplasm]

Ub-33-UBB(1-76) [nucleoplasm]

Ub-11-UBB(1-76) [nucleoplasm]

Ub-87-UBB(77-152) [nucleoplasm]

Ub-163-UBB(153-228) [nucleoplasm]

Ub-139-UBB(77-152) [endosome membrane]

Ub-215-UBB(153-228) [endosome membrane]

Ub-63-UBB(1-76) [endosome membrane]

Ub-139-UBB(77-152) [plasma membrane]

Ub-63-UBB(1-76) [plasma membrane]

Ub-215-UBB(153-228) [plasma membrane]

Ub-11-UBB(1-76) [cytosol]

Ub-163-UBB(153-228) [cytosol]

Ub-87-UBB(77-152) [cytosol]

Ub-139-UBB(77-152) [cytosol]

Ub-215-UBB(153-228) [cytosol]

Ub-63-UBB(1-76) [cytosol]

UBB(153-228) [lysosomal lumen]

UBB(1-76) [lysosomal lumen]

UBB(77-152) [lysosomal lumen]

UBB(1-76) [cytosol]

UBB(77-152) [cytosol]

UBB(153-228) [cytosol]

p-S65-UBB(1-76) [mitochondrial outer membrane]

p-S217-UBB(153-228) [mitochondrial outer membrane]

p-S141-UBB(77-152) [mitochondrial outer membrane]

Ub-200-UBB(153-228) [cytosol]

Ub-124-UBB(77-152) [cytosol]

Ub-48-UBB(1-76) [cytosol]

UBB(1-76) [mitochondrial outer membrane]

UBB(153-228) [mitochondrial outer membrane]

UBB(77-152) [mitochondrial outer membrane]

UBB(1-76) [late endosome lumen]

UBB(77-152) [late endosome lumen]

UBB(153-228) [late endosome lumen]

Ub-158-UBB(153-228) [nucleoplasm]

Ub-6-UBB(1-76) [nucleoplasm]

Ub-82-UBB(77-152) [nucleoplasm]

Ub-215-UBB(153-228) [nucleoplasm]

Ub-63-UBB(1-76) [nucleoplasm]

Ub-139-UBB(77-152) [nucleoplasm]

Ub-200-UBB(153-228) [nucleoplasm]

Ub-124-UBB(77-152) [nucleoplasm]

Ub-48-UBB(1-76) [nucleoplasm]

UBB(153-228) [nucleoplasm]

UBB(1-76) [nucleoplasm]

UBB(77-152) [nucleoplasm]

Inferred To

UBC [mitochondrial outer membrane] (Sus scrofa)

Ubc [mitochondrial outer membrane] (Mus musculus)

ubq-2 [mitochondrial outer membrane] (Caenorhabditis elegans)

Ubi-p5E5 [mitochondrial outer membrane] (Drosophila melanogaster)

UBB [mitochondrial outer membrane] (Bos taurus)

UBB [mitochondrial outer membrane] (Canis familiaris)

Ubb [mitochondrial outer membrane] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine at 139

Coordinate

139

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_061828.1, NP_001268647.1, NP_001268648.1, NP_001268645.1, NP_001268646.1, NP_001268649.1

OpenTargets

ENSG00000170315

ENSEMBL

ENST00000395837, ENST00000395839, ENSP00000379178, ENSP00000379180, ENST00000614404, ENST00000302182, ENSP00000478771, ENSP00000304697

HPA

ENSG00000170315-UBB

PRO

P0CG47

Pharos - Targets

P0CG47

GlyGen

P0CG47

Orphanet

UBB

PDB

5XK5, 5JBY, 7MYH, 5L8H, 7UV5, 5ULK, 5BNB, 7YQK, 7JMS, 4ZFR, 5O44, 8G6S, 5GOH, 7W3I, 7W3K, 6JMA, 2MSG, 7AY2, 5YIK, 8SN6, 5OHL, 7OJX, 5D0K, 5YDR, 8A67, 8BS9, 6K9P, 6XQC, 8DMQ, 5XK4, 7NBB, 6NJ9, 7M2K, 8CMR, 8TXV, 6H4H, 4XOF, 7LYC, 5GOG, 7W39, 8WG5, 7RBR, 6MSD, 5KGF, 8SN3, 7OJE, 6BVA, 5VNZ, 5JG6, 5D0M, 8GRM, 8J1P, 8IC9, 4ZPZ, 6OAM, 6FYH, 6C16, 7W3B, 5UJN, 5H7S, 5ULH, 8XEP, 5GOK, 6FDK, 8EFW, 6PZV, 5JTJ, 6XZ1, 6QK9, 6GLC, 7MYF, 5XPK, 6K4I, 7W3F, 5VZW, 5KYE, 5N2W, 5OHK, 8C07, 4UF6, 5VF0, 5V1Z, 6FX4, 6ISU, 7CAP, 6CP2, 5GOD, 7QO4, 6GZS, 5ZBU, 7W3C, 6JB6, 5ZD0, 6XAA, 8SN5, 6PGV, 7W3M, 4WLR, 5YIJ, 6DGF, 7UD5, 5VO0, 5N38, 5LRW, 4UEL, 5XBO, 5NVG, 8EFX, 6FGE, 8DMS, 6QF8, 5MNJ, 5L8W, 2N13, 4WHV, 5GOI, 8H1T, 5GOB, 7W38, 7W3H, 2MRO, 8SN8, 5CVN, 5EMZ, 8TXX, 4WUR, 7MEY, 7DNJ, 5YT6, 5EDV, 7W54, 5JTV, 5GO7, 5ULF, 7BU0, 5KYF, 6O96, 5X3O, 8OYP, 6BYH, 6QML, 5VEY, 5TOF, 8HQY, 5DK8, 6UH5, 4ZUX, 7W3A, 8SN9, 5LN1, 6FTX, 6HEI, 5YMY, 5GJQ, 6MSE, 6JB7, 5IBK, 5TUT, 5NLJ, 5OHP, 5IFR, 8G6Q, 5LRX, 7NPO, 7US1, 5X3N, 5V1Y, 6TBM, 7BBD, 7QO5, 8Q00, 8SN7, 8ITP, 5M93, 6HEK, 7W3J, 8DU4, 7RMA, 5JP3, 5TXK, 5O6T, 5CVM, 8G6G, 6MSG, 7F7X, 5CAW, 6KOW, 5GOJ, 6NJG, 5UJL, 6IF1, 5WFI, 7W3U, 5X3M, 5DFL, 5KHY, 5NL5, 5W46, 6ASR, 2KHW, 6LP2, 5TOG, 7XCT, 5KYD, 6EI1, 8SNA, 6MSB, 6KOX, 5XDP, 5CRA, 5GOC, 6N13, 7MC9, 5CVO, 8TXW, 8G6H, 8SN4, 7W3G, 5GO8, 5L9T, 5OHN, 7DNI, 4ZFT, 5E6J, 5VZM, 7E8I, 2MBB, 5LRV, 5EYA, 5K9P, 7XCR, 8EHO, 5KYC

Interactors (110)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15038 DAZP2			0.742	7
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.742	5
UniProt:Q9Y3C5 RNF11			0.728	4
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.683	4
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.669	3
UniProt:P54727 RAD23B	2	RAD23B [cytosol] (R-HSA-8850589) RAD23B [nucleoplasm] (R-HSA-62590)	0.666	5
UniProt:P0C0S8 H2AC11	11	Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311) HIST1H2AG [nucleoplasm] (R-HSA-212084) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237)	0.65	14
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.643	4
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [early endosome membrane] (R-HSA-2029032) RABGEF1 [cytosol] (R-HSA-8875419)	0.632	6
UniProt:Q9HAU4 SMURF2	2	SMURF2 [nucleoplasm] (R-HSA-178202) SMURF2 [cytosol] (R-HSA-173537)	0.623	4
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.59	2
UniProt:Q9UKT6 FBXL21P	1	FBXL21 [cytosol] (R-HSA-8862606)	0.589	2
UniProt:A0PJX0 CIB4			0.589	2
UniProt:Q60592 MAST2			0.589	2
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.581	3
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)	0.564	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.564	2
UniProt:Q6ZTR5 CFA47			0.564	2
UniProt:O75881 CYP7B1	10	CYP7B1 Y275* [endoplasmic reticulum membrane] (R-HSA-5602888) CYP7B1 T297A [endoplasmic reticulum membrane] (R-HSA-5602952) CYP7B1 F216S [endoplasmic reticulum membrane] (R-HSA-5602926) CYP7B1 G87V [endoplasmic reticulum membrane] (R-HSA-5603020) CYP7B1 F470I [endoplasmic reticulum membrane] (R-HSA-5602893) CYP7B1 S363F [endoplasmic reticulum membrane] (R-HSA-5603011) CYP7B1 G57R [endoplasmic reticulum membrane] (R-HSA-5602867) CYP7B1 R417H [endoplasmic reticulum membrane] (R-HSA-5602944) CYP7B1 R388* [endoplasmic reticulum membrane] (R-HSA-5602900) CYP7B1 [endoplasmic reticulum membrane] (R-HSA-192117)	0.564	2
UniProt:Q9NRQ2 PLS4			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:O60260-5 PRKN			0.556	6
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.556	3
UniProt:Q8NA23-2 Q8NA232			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.556	3
UniProt:Q9H305 CDIP1			0.556	3
UniProt:P45974-2 USP5			0.556	3
UniProt:P00441 SOD1	5	2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [extracellular region] (R-HSA-350705)	0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q6ICB0 DESI1			0.556	3
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.544	2
UniProt:Q9UBU6 FA8A1			0.527	2
UniProt:Q99679 GPR21			0.527	2
UniProt:Q9NS26 SPNXA			0.527	2
UniProt:P56539 CAV3	1	CAV3 [plasma membrane] (R-HSA-1368135)	0.527	2
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.527	2
UniProt:Q13137 CACO2			0.527	2
UniProt:Q9UHP6 RSP14			0.527	2
UniProt:Q8NI37 PPTC7			0.527	2
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.527	2
UniProt:Q9Y6B2 EID1			0.527	2
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	2
UniProt:Q9BQ31 KCNS3	1	KCNS3 [plasma membrane] (R-HSA-381709)	0.527	2
UniProt:Q9NQP4 PFDN4	1	PFDN4 [cytosol] (R-HSA-379542)	0.527	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	2
UniProt:P53673 CRBA4			0.527	2
UniProt:Q15382 RHEB	2	RHEB [endosome membrane] (R-HSA-5656350) RHEB [lysosomal membrane] (R-HSA-165190)	0.527	2
UniProt:Q7L4E1 MIGA2	1	MIGA2 [mitochondrial outer membrane] (R-HSA-8954402)	0.527	2
UniProt:Q96S79 RSLAB			0.527	2
UniProt:Q9H8M7 MINY3			0.527	2
UniProt:Q9UHF4 IL20RA	1	IL20RA [plasma membrane] (R-HSA-448713)	0.527	2
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.527	3
UniProt:Q9UHV8 PP13			0.527	2
UniProt:Q6P158 DHX57			0.527	2
UniProt:Q9H9Q2 COPS7B	2	COPS7B [nucleoplasm] (R-HSA-5697023) COPS7B [cytosol] (R-HSA-416966)	0.527	2
UniProt:P31751 AKT2	7	p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087) p-T309,S474-AKT2 [cytosol] (R-HSA-202062) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) AKT2 [plasma membrane] (R-HSA-202053) AKT2 [cytosol] (R-HSA-49859) p-T309-AKT2 [cytosol] (R-HSA-202066) p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056)	0.527	2
UniProt:Q96S82 UBL7			0.527	2
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.527	2
UniProt:Q9NYS7 WSB2	1	WSB2 [cytosol] (R-HSA-8863349)	0.527	2
UniProt:Q9NX08 COMMD8	2	COMMD8 [nucleoplasm] (R-HSA-8955102) COMMD8 [cytosol] (R-HSA-8955107)	0.527	2
UniProt:P49770 EIF2B2	1	EIF2B2 [cytosol] (R-HSA-72519)	0.527	2
UniProt:Q9BV87 CNPD1			0.527	2
UniProt:O95704 APBB3			0.527	2
UniProt:Q6NVH7 SWAP1			0.527	2
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.527	3
UniProt:Q9UBH0 IL36RN	1	IL36RN [extracellular region] (R-HSA-8940995)	0.527	2
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.527	2
UniProt:Q969T4 UBE2E3	4	UBE2E3 [cytosol] (R-HSA-947633) UBE2E3 [nucleoplasm] (R-HSA-8852108) Ub-C145-UBE2E3 [nucleoplasm] (R-HSA-8864208) Ub-C145-UBE2E3 [cytosol] (R-HSA-8864162)	0.527	2
UniProt:Q8N461 FBXL16	1	FBXL16 [cytosol] (R-HSA-8862609)	0.527	2
UniProt:Q15771 RAB30	3	RAB30 [Golgi membrane] (R-HSA-8849598) GGC-RAB30 [cytosol] (R-HSA-8873972) RAB30 [cytosol] (R-HSA-8873677)	0.527	2
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.527	2
UniProt:Q86VN1 VPS36	1	VPS36 [cytosol] (R-HSA-917709)	0.527	2
UniProt:O43548 TGM5	1	TGM5 [plasma membrane] (R-HSA-6814176)	0.527	2
UniProt:Q9H7B7 CG069			0.527	2
UniProt:Q9NYQ3 HAO2	2	HAO2 [cytosol] (R-HSA-9033093) HAO2 [peroxisomal matrix] (R-HSA-6787806)	0.527	2
UniProt:Q8N4T0 CBPA6			0.527	2
UniProt:Q99732 LITAF			0.527	2
UniProt:P52758 HRSP12	1	HRSP12 [cytosol] (R-HSA-9014634)	0.527	2
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.527	2
UniProt:O94832 MYO1D			0.527	2
UniProt:Q9BSH3 NICN1	1	NICN1 [cytosol] (R-HSA-8955331)	0.527	2
UniProt:P55345 ANM2			0.527	3
UniProt:Q9Y5Q0 FADS3			0.527	2
UniProt:Q86UW1 SLC51A	1	SLC51A [plasma membrane] (R-HSA-9733981)	0.527	2
UniProt:P53680 AP2S1	4	AP2S1 [endolysosome membrane] (R-HSA-6784821) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [cytosol] (R-HSA-182197) AP2S1 [plasma membrane] (R-HSA-389382)	0.527	2
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.527	2
UniProt:Q9NRD1 FBXO6	1	FBXO6 [cytosol] (R-HSA-391296)	0.527	2
UniProt:O00220 TNFRSF10A	1	TNFRSF10A [plasma membrane] (R-HSA-5633393)	0.527	3
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.527	3
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.527	2
UniProt:P49356 FNTB	1	FNTB [cytosol] (R-HSA-2530482)	0.527	2
UniProt:Q9BV68 RNF126	1	RNF126 [cytosol] (R-HSA-8851642)	0.527	2
UniProt:Q9BQE5 APOL2			0.527	2
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) UBE2D2 [cytosol] (R-HSA-934628) UBE2D2 [nucleoplasm] (R-HSA-8852067) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153)	0.527	2
UniProt:P22612 PRKACG	3	PRKACG [ciliary base] (R-HSA-5610405) PRKACG [cytosol] (R-HSA-57848) PRKACG [nucleoplasm] (R-HSA-111938)	0.527	2
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.527	2
UniProt:P58062 ISK7			0.527	2
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.527	2
UniProt:O76075 DFFB	2	DFFB [cytosol] (R-HSA-211211) DFFB [nucleoplasm] (R-HSA-211195)	0.527	2
UniProt:Q9DLK6 Q9DLK6			0.524	2
UniProt:P24610	1	Pax3 [nucleoplasm] (R-MMU-5603237)	0.524	2
UniProt:Q8IVM0 CCD50			0.508	2
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [recycling endosome membrane] (R-HSA-8875655)	0.508	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2