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K63polyUb-RNF123 [cytosol]
Stable Identifier
R-HSA-6783055
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase RNF123, RN123_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP19 deubiquitinates RNF123 (Homo sapiens)
USP19:K63polyUb-RNF123 [cytosol] (Homo sapiens)
K63polyUb-RNF123 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5XPI4 RNF123
Gene Names
RNF123, KPC1, FP1477
Chain
initiator methionine:, chain:2-1314
Reference Genes
BioGPS Gene:63891 RNF123
COSMIC (genes):RNF123 RNF123
CTD Gene:63891 RNF123
dbSNP Gene:63891 RNF123
ENSEMBL:ENSG00000164068 RNF123
HGNC:21148 RNF123
KEGG:hsa:63891 RNF123
Monarch:63891 RNF123
NCBI Gene:63891 RNF123
OMIM:614472 RNF123
UCSC:Q5XPI4 RNF123
Reference Transcript
RefSeq:XM_006713285.1 RNF123
RefSeq:NM_022064.4 RNF123
RefSeq:XM_011533995.1 RNF123
RefSeq:XM_017007018.1 RNF123
Other Identifiers
11741002_a_at
11744979_a_at
16940766
221063_PM_x_at
221063_x_at
224186_PM_s_at
224186_s_at
2398408
2622241
2622242
2622244
2622245
2622246
2622247
2622249
2622250
2622251
2622252
2622253
2622254
2622255
2622256
2622258
2622259
2622260
2622261
2622262
2622263
2622265
2622266
2622267
2622268
2622269
2622270
2622271
2622273
2622274
2622275
2622276
2622277
2622278
2622280
2622282
2622283
2622284
2622285
2622286
2622287
2622288
2622289
2622290
2622291
2622292
2622293
2622294
2622295
2622296
2622299
2622300
2622301
2622302
2622303
2622304
2622305
2622306
2622307
2622308
2622309
54629_at
63891
8079796
A_14_P131061
A_14_P133902
A_14_P200092
A_23_P250054
GE56894
GE82644
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005829
GO:0006511
GO:0016567
GO:0016740
GO:0031965
GO:0046872
GO:0051603
GO:0051604
GO:0061630
GO:0140096
HMNXSV003013112
ILMN_1663605
PH_hs_0030702
TC03000298.hg
TC03002331.hg
g11545772_3p_a_at
g11545772_3p_s_at
Participates
as a component of
USP19:K63polyUb-RNF123 [cytosol] (Homo sapiens)
Other forms of this molecule
RNF123 [cytosol]
Inferred To
RNF123 [cytosol]
(Bos taurus)
RNF123 [cytosol]
(Canis familiaris)
RNF123 [cytosol]
(Sus scrofa)
K63polyUb-RNF123 [cytosol]
(Dictyostelium discoideum)
K63polyUb-RNF123 [cytosol]
(Gallus gallus)
K63polyUb-RNF123 [cytosol]
(Mus musculus)
K63polyUb-RNF123 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ENSEMBL
ENST00000327697
,
ENSP00000328287
,
ENSG00000164068
OpenTargets
ENSG00000164068
IntEnz
2.3.2.27
GeneCards
RNF123
HPA
ENSG00000164068-RNF123
PRO
Q5XPI4
Pharos - Targets
Q5XPI4
GlyGen
Q5XPI4
PDB
2MA6
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.553
2
UniProt:Q96NR8 RDH12
6
RDH12 [photoreceptor inner segment membrane]
(R-HSA-2464787)
RDH12 Ala269Glyfs*2 [photoreceptor inner segment membrane]
(R-HSA-2471748)
RDH12 H151N [photoreceptor inner segment membrane]
(R-HSA-2471751)
RDH12 Y226C [photoreceptor inner segment membrane]
(R-HSA-2471697)
RDH12 Q189* [photoreceptor inner segment membrane]
(R-HSA-2471667)
RDH12 A126V [photoreceptor inner segment membrane]
(R-HSA-2471753)
0.527
2
UniProt:Q9BQ52 ELAC2
3
ELAC2 [mitochondrial matrix]
(R-HSA-6786837)
ELAC2 [nucleoplasm]
(R-HSA-5696766)
ELAC2 [cytosol]
(R-HSA-9708824)
0.527
3
UniProt:O60294 LCMT2
1
LCMT2 [cytoplasm]
(R-HSA-6782869)
0.527
3
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