Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PolyUb-CCNA2 [nucleoplasm]
Stable Identifier
R-HSA-6783099
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CCNA2, Cyclin A2, Cyclin A
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)
USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2 [nucleoplasm] (Homo sapiens)
PolyUb-CCNA [nucleoplasm] (Homo sapiens)
PolyUb-CCNA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20248 CCNA2
Gene Names
CCNA2, CCN1, CCNA
Chain
chain:1-432
Reference Genes
BioGPS Gene:890 CCNA2
COSMIC (genes):CCNA2 CCNA2
CTD Gene:890 CCNA2
dbSNP Gene:890 CCNA2
ENSEMBL:ENSG00000145386 CCNA2
ENSEMBL_homo_sapiens_GENE:ENSG00000145386.11 CCNA2
HGNC:1578 CCNA2
KEGG Gene (Homo sapiens):890 CCNA2
Monarch:890 CCNA2
NCBI Gene:890 CCNA2
OMIM:123835 CCNA2
UCSC:P20248 CCNA2
Reference Transcript
RefSeq:NM_001237.4 CCNA2
Other Identifiers
11722571_at
11722572_at
16979515
1943_at
203418_PM_at
203418_at
213226_PM_at
213226_at
2784114
2784115
2784116
2784117
2784119
2784120
2784121
2784122
2784123
2784125
2784128
2784129
2784130
40697_at
8102643
890
A_23_P58321
GE59759
GO:0000082
GO:0000086
GO:0000278
GO:0000307
GO:0001939
GO:0001940
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006260
GO:0006275
GO:0006351
GO:0006355
GO:0007049
GO:0007265
GO:0016538
GO:0019901
GO:0019904
GO:0023052
GO:0031100
GO:0032355
GO:0033762
GO:0036120
GO:0036211
GO:0043226
GO:0043687
GO:0044320
GO:0044772
GO:0044843
GO:0045893
GO:0048146
GO:0048856
GO:0051301
GO:0071314
GO:0071373
GO:0071392
GO:0071407
GO:0071456
GO:0071732
GO:0090102
GO:0097122
GO:0097124
GO:0098772
GO:1990314
GO:2000573
HMNXSV003001266
Hs.91728.1.A1_3p_at
ILMN_1786125
PH_hs_0004815
TC04001516.hg
X51688_at
g4502612_3p_at
Participates
as a member of
PolyUb-CCNA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CCNA2 [cytosol]
CCNA2 [nucleoplasm]
Inferred To
CCNA2 [nucleoplasm]
(Bos taurus)
CCNA2 [nucleoplasm]
(Canis familiaris)
CCNA2 [nucleoplasm]
(Gallus gallus)
CCNA2 [nucleoplasm]
(Sus scrofa)
ccna2 [nucleoplasm]
(Danio rerio)
ccna2 [nucleoplasm]
(Xenopus tropicalis)
Ccna2 [nucleoplasm]
(Mus musculus)
Ccna2 [nucleoplasm]
(Rattus norvegicus)
CycA [nucleoplasm]
(Drosophila melanogaster)
crs1 [nucleoplasm]
(Schizosaccharomyces pombe)
cya-1 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position
Modification
PolyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001228.1
OpenTargets
ENSG00000145386
GeneCards
P20248
HPA
ENSG00000145386-CCNA2
ZINC - Substances
CCNA2_HUMAN
Ensembl
ENST00000274026
,
ENSP00000274026
,
ENSG00000145386
ZINC target
P20248
PRO
P20248
Pharos - Targets
P20248
ZINC - Predictions - Purchasable
CCNA2_HUMAN
PDB
2WFY
,
6ATH
,
4EOP
,
2UZL
,
2WMA
,
2UUE
,
1H26
,
1H28
,
1GY3
,
1FVV
,
1H27
,
1H1P
,
1OIU
,
7B7S
,
2CCH
,
1OGU
,
2I40
,
6Q6H
,
1H1R
,
4CFW
,
7B5L
,
1H1Q
,
1H1S
,
4EON
,
2C4G
,
4EOM
,
6Q6G
,
1JST
,
2WPA
,
1OKW
,
4EOQ
,
1OL1
,
1JSU
,
1OL2
,
4EOO
,
7QHL
,
1P5E
,
7MKX
,
2CJM
,
3EOC
,
4CFN
,
2BPM
,
4CFM
,
2IW6
,
4BCN
,
2C5O
,
2WEV
,
2V22
,
2WIH
,
2C5N
,
1OKV
,
7LUO
,
1URC
,
2WHB
,
2CCI
,
2WIP
,
4BCP
,
4EOR
,
5LMK
,
1PKD
,
2UZD
,
4FX3
,
4EOJ
,
4EOI
,
3F5X
,
4CFU
,
2WMB
,
5CYI
,
2C6T
,
2X1N
,
1QMZ
,
2WXV
,
1VYW
,
6SG4
,
2C5V
,
2UZB
,
2C5X
,
1E9H
,
4CFV
,
7B5R
,
1OIY
,
1OI9
,
2UZE
,
6GVA
,
1H24
,
8B54
,
7ACK
,
5IF1
,
1H25
,
4CFX
,
2BKZ
,
6P3W
,
8BYA
,
3EID
,
4BCK
,
4EOS
,
6RIJ
,
3EJ1
,
5NEV
,
4EOL
,
8BZO
,
4BCM
,
4EOK
,
2IW9
,
2IW8
,
1FIN
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.977
33
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.967
21
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.837
9
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.802
8
UniProt:Q9BY12 SCAPE
0.744
6
UniProt:Q13415 ORC1
5
ORC1 [nucleoplasm]
(R-HSA-68522)
ORC1 [cytosol]
(R-HSA-113840)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
0.725
5
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.725
6
UniProt:Q99640 PKMYT1
3
PKMYT1 [cytosol]
(R-HSA-157457)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [nucleoplasm]
(R-HSA-74386)
0.725
6
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.725
6
UniProt:Q9H211 CDT1
1
CDT1 [nucleoplasm]
(R-HSA-68536)
0.725
7
UniProt:Q08999 RBL2
2
RBL2 [nucleoplasm]
(R-HSA-389102)
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
0.69
7
UniProt:Q00526 CDK3
0.643
5
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.643
5
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.643
3
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.643
4
UniProt:Q9H147 TDIF1
0.643
4
UniProt:Q6PJG2 MDEAS
0.643
5
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.643
6
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.643
4
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.623
4
UniProt:P03129 VE7
0.564
2
UniProt:Q8NG08 HELB
0.527
3
UniProt:Q9Y3Z3 SAMHD1
1
SAMHD1 [nucleoplasm]
(R-HSA-5624198)
0.527
2
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.527
3
UniProt:P50613 CDK7
1
CDK7 [nucleoplasm]
(R-HSA-69218)
0.527
2
UniProt:P49918-2 CDKN1C
0.527
2
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.527
4
UniProt:Q9Y463 DYR1B
0.527
2
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.527
3
UniProt:P09681 GIP
6
GIP(22-153) [endoplasmic reticulum lumen]
(R-HSA-400512)
GIP(22-153) [secretory granule lumen]
(R-HSA-400526)
GIP(52-93) [secretory granule lumen]
(R-HSA-400483)
GIP(54-93) [extracellular region]
(R-HSA-400542)
GIP(1-153) [endoplasmic reticulum lumen]
(R-HSA-400470)
GIP(52-93) [extracellular region]
(R-HSA-400540)
0.527
2
UniProt:P33552 CKS2
0.527
4
UniProt:P19525 EIF2AK2
5
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
EIF2AK2 [cytosol]
(R-HSA-168699)
0.527
2
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.527
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.524
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text