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OTUB1 [nucleoplasm]
Stable Identifier
R-HSA-6783242
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin thioesterase OTUB1, OTUB1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Homo sapiens)
OTUB1,(OTUB2) [nucleoplasm] (Homo sapiens)
OTUB1 [nucleoplasm] (Homo sapiens)
OTUB1,(OTUB2):UBE2D1,ESR1 [nucleoplasm] (Homo sapiens)
OTUB1,(OTUB2) [nucleoplasm] (Homo sapiens)
OTUB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96FW1 OTUB1
Gene Names
OTUB1, OTB1, OTU1, HSPC263
Chain
initiator methionine:1, chain:2-271
Reference Genes
BioGPS Gene:55611 OTUB1
COSMIC (genes):OTUB1 OTUB1
CTD Gene:55611 OTUB1
dbSNP Gene:55611 OTUB1
ENSEMBL:ENSG00000167770 OTUB1
HGNC:23077 OTUB1
KEGG Gene (Homo sapiens):55611 OTUB1
Monarch:55611 OTUB1
NCBI Gene:55611 OTUB1
OMIM:608337 OTUB1
UCSC:Q96FW1 OTUB1
Reference Transcript
RefSeq:NM_017670.2 OTUB1
Other Identifiers
0007100672
11717771_a_at
11717772_a_at
16726188
201245_3p_s_at
201245_s_at
201246_s_at
3334138
3334139
3334141
3334142
3334145
3334148
3334151
3334153
3334154
3334156
3334159
3334160
3334161
3334162
3334163
3334164
3334166
38710_at
55611
7940840
A_14_P129860
A_23_P24375
A_32_P58816
GE56373
GO:0002250
GO:0002376
GO:0003674
GO:0004843
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006281
GO:0006464
GO:0006508
GO:0006950
GO:0006974
GO:0008150
GO:0008233
GO:0008234
GO:0016579
GO:0016787
GO:0019784
GO:0019899
GO:0031625
GO:0032182
GO:0034641
GO:0036459
GO:0043130
GO:0043226
GO:0051276
GO:0070062
GO:0071108
GO:0071347
GO:1901315
GO:2000780
Hs.108504.0.S1_3p_a_at
Hs.108504.0.S1_3p_s_at
ILMN_1723871
ILMN_1778017
ILMN_2354855
PH_hs_0026447
TC11002711.hg
g8923113_3p_s_at
Participant Of
hasMember
OTUB1,(OTUB2) [nucleoplasm]
Other forms of this molecule
OTUB1 [cytosol]
Inferred To
otub-1 [nucleoplasm] (Caenorhabditis elegans)
OTUB1 [nucleoplasm] (Bos taurus)
OTUB1 [nucleoplasm] (Canis familiaris)
OTUB1 [nucleoplasm] (Drosophila melanogaster)
OTUB1 [nucleoplasm] (Gallus gallus)
OTUB1 [nucleoplasm] (Plasmodium falciparum)
OTUB1 [nucleoplasm] (Sus scrofa)
otub1a [nucleoplasm] (Danio rerio)
Otub1 [nucleoplasm] (Mus musculus)
Otub1 [nucleoplasm] (Rattus norvegicus)
Cross References
RefSeq
NP_060140.2
OpenTargets
ENSG00000167770
GeneCards
Q96FW1
HPA
ENSG00000167770-OTUB1
Ensembl
ENSP00000444357
,
ENSP00000402551
,
ENST00000538426
,
ENST00000428192
,
ENSG00000167770
PRO
Q96FW1
PDB
4DDI
,
4LDT
,
4DDG
,
2ZFY
,
4DHZ
,
3VON
,
4I6L
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61088 UBE2N
5
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
UBE2N [nucleoplasm]
(R-HSA-5682541)
UBE2N [cytosol]
(R-HSA-206072)
0.74
5
UniProt:P22314 UBA1
2
UBA1 [nucleoplasm]
(R-HSA-8852116)
UBA1 [cytosol]
(R-HSA-947698)
0.666
4
UniProt:Q99497 PARK7
7
PARK7 [nucleoplasm]
(R-HSA-3900141)
SUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
0.666
4
UniProt:Q00987 MDM2
11
SUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.632
5
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.632
8
UniProt:P43246 MSH2
3
MSH2 GLN601TER [nucleoplasm]
(R-HSA-5577243)
MSH2 [nucleoplasm]
(R-HSA-5357525)
MSH2 R406* [nucleoplasm]
(R-HSA-5575594)
0.564
3
UniProt:P14136 GFAP
3
GFAP [lysosomal membrane]
(R-HSA-9625195)
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:P0CG47 UBB
109
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-110-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-186-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-182-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
Ub-106-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783103)
Ub-27-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783038)
Ub-180-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783114)
Ub-104-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783149)
N6-glycyl-L-lysine-UBB(1-76) [cytosol]
(R-HSA-8869049)
N6-glycyl-L-lysine-UBB(153-228) [cytosol]
(R-HSA-8869046)
N6-glycyl-L-lysine-UBB(77-152) [cytosol]
(R-HSA-8869047)
adenylatedG152-UBB(77-152) [nucleoplasm]
(R-HSA-8852094)
adenylatedG228-UBB(153-228) [nucleoplasm]
(R-HSA-8852104)
adenylatedG76-UBB(1-76) [nucleoplasm]
(R-HSA-8852101)
UBB [cytosol]
(R-HSA-8853516)
adenylatedG76-UBB(1-76) [cytosol]
(R-HSA-8852121)
adenylatedG228-UBB(153-228) [cytosol]
(R-HSA-8852049)
adenylatedG152-UBB(77-152) [cytosol]
(R-HSA-8852113)
Ub-124-UBB(77-152) [endoplasmic reticulum membrane]
(R-HSA-8943100)
Ub-48-UBB(1-76) [endoplasmic reticulum membrane]
(R-HSA-8943138)
Ub-200-UBB(153-228) [endoplasmic reticulum membrane]
(R-HSA-8943117)
UBB(153-228) [plasma membrane]
(R-HSA-3149455)
UBB(1-76) [plasma membrane]
(R-HSA-3149453)
UBB(77-152) [plasma membrane]
(R-HSA-3149463)
UBB(77-152) [endosome membrane]
(R-HSA-939251)
UBB(1-76) [endosome membrane]
(R-HSA-939240)
UBB(153-228) [endosome membrane]
(R-HSA-939247)
UBB(153-228) [endoplasmic reticulum membrane]
(R-HSA-8943098)
UBB(77-152) [endoplasmic reticulum membrane]
(R-HSA-8943111)
UBB(1-76) [endoplasmic reticulum membrane]
(R-HSA-8943078)
Ub-106-UBB(77-152) [cytosol]
(R-HSA-5689191)
Ub-182-UBB(153-228) [cytosol]
(R-HSA-5689214)
Ub-29-UBB(1-76) [cytosol]
(R-HSA-5689207)
Ub-158-UBB(153-228) [cytosol]
(R-HSA-5689099)
Ub-82-UBB(77-152) [cytosol]
(R-HSA-5689080)
Ub-6-UBB(1-76) [cytosol]
(R-HSA-5689075)
Ub-33-UBB(1-76) [cytosol]
(R-HSA-5689198)
Ub-186-UBB(153-228) [cytosol]
(R-HSA-5689146)
Ub-110-UBB(77-152) [cytosol]
(R-HSA-5689203)
Ub-27-UBB(1-76) [cytosol]
(R-HSA-5689161)
Ub-104-UBB(77-152) [cytosol]
(R-HSA-5689139)
Ub-180-UBB(153-228) [cytosol]
(R-HSA-5689138)
Ub-11-UBB(1-76) [cytosol]
(R-HSA-3095929)
Ub-163-UBB(153-228) [cytosol]
(R-HSA-3095932)
Ub-87-UBB(77-152) [cytosol]
(R-HSA-3095917)
Ub-139-UBB(77-152) [endosome membrane]
(R-HSA-939217)
Ub-215-UBB(153-228) [endosome membrane]
(R-HSA-939193)
Ub-63-UBB(1-76) [endosome membrane]
(R-HSA-939167)
Ub-139-UBB(77-152) [plasma membrane]
(R-HSA-939867)
Ub-63-UBB(1-76) [plasma membrane]
(R-HSA-939872)
Ub-215-UBB(153-228) [plasma membrane]
(R-HSA-939852)
Ub-27-UBB(1-76) [nucleoplasm]
(R-HSA-6782673)
Ub-180-UBB(153-228) [nucleoplasm]
(R-HSA-6782604)
Ub-104-UBB(77-152) [nucleoplasm]
(R-HSA-6782627)
Ub-106-UBB(77-152) [nucleoplasm]
(R-HSA-6782652)
Ub-182-UBB(153-228) [nucleoplasm]
(R-HSA-6782665)
Ub-29-UBB(1-76) [nucleoplasm]
(R-HSA-6782595)
Ub-124-UBB(77-152) [nucleoplasm]
(R-HSA-6782527)
Ub-48-UBB(1-76) [nucleoplasm]
(R-HSA-6782505)
Ub-200-UBB(153-228) [nucleoplasm]
(R-HSA-6782478)
Ub-11-UBB(1-76) [nucleoplasm]
(R-HSA-6782649)
Ub-87-UBB(77-152) [nucleoplasm]
(R-HSA-6782607)
Ub-163-UBB(153-228) [nucleoplasm]
(R-HSA-6782598)
Ub-186-UBB(153-228) [nucleoplasm]
(R-HSA-6782655)
Ub-110-UBB(77-152) [nucleoplasm]
(R-HSA-6782591)
Ub-33-UBB(1-76) [nucleoplasm]
(R-HSA-6782601)
UBB(77-152) [nucleoplasm]
(R-HSA-939870)
UBB(1-76) [nucleoplasm]
(R-HSA-939847)
UBB(153-228) [nucleoplasm]
(R-HSA-939854)
Ub-48-UBB(1-76) [nucleoplasm]
(R-HSA-5683040)
Ub-124-UBB(77-152) [nucleoplasm]
(R-HSA-5683036)
Ub-200-UBB(153-228) [nucleoplasm]
(R-HSA-5683038)
Ub-139-UBB(77-152) [nucleoplasm]
(R-HSA-6782488)
Ub-63-UBB(1-76) [nucleoplasm]
(R-HSA-6782489)
Ub-215-UBB(153-228) [nucleoplasm]
(R-HSA-6782475)
Ub-82-UBB(77-152) [nucleoplasm]
(R-HSA-6782683)
Ub-6-UBB(1-76) [nucleoplasm]
(R-HSA-6782600)
Ub-158-UBB(153-228) [nucleoplasm]
(R-HSA-6782639)
UBB(153-228) [late endosome lumen]
(R-HSA-9660014)
UBB(77-152) [late endosome lumen]
(R-HSA-9660021)
UBB(1-76) [late endosome lumen]
(R-HSA-9660017)
Ub-48-UBB(1-76) [cytosol]
(R-HSA-939249)
Ub-124-UBB(77-152) [cytosol]
(R-HSA-939225)
Ub-200-UBB(153-228) [cytosol]
(R-HSA-939197)
UBB(153-228) [cytosol]
(R-HSA-939230)
UBB(77-152) [cytosol]
(R-HSA-939213)
UBB(1-76) [cytosol]
(R-HSA-939214)
UBB(77-152) [lysosomal lumen]
(R-HSA-9660011)
UBB(1-76) [lysosomal lumen]
(R-HSA-9660024)
UBB(153-228) [lysosomal lumen]
(R-HSA-9660025)
Ub-63-UBB(1-76) [cytosol]
(R-HSA-939224)
Ub-215-UBB(153-228) [cytosol]
(R-HSA-939168)
Ub-139-UBB(77-152) [cytosol]
(R-HSA-939235)
0.556
3
UniProt:O76024 WFS1
3
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:O14773 TPP1
1
TPP1 [lysosomal lumen]
(R-HSA-535504)
0.556
3
UniProt:P00441 SOD1
5
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [extracellular region]
(R-HSA-350705)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
0.556
3
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:Q13490 BIRC2
5
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2 [cytosol]
(R-HSA-50847)
0.499
3
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