Reactome | OTUB1 [nucleoplasm]

OTUB1 [nucleoplasm]

Stable Identifier

R-HSA-6783242

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin thioesterase OTUB1, OTUB1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96FW1 OTUB1

Gene Names

OTUB1, OTB1, OTU1, HSPC263

Chain

initiator methionine:1, chain:2-271

Reference Genes

BioGPS Gene:55611 OTUB1

COSMIC (genes):OTUB1 OTUB1

CTD Gene:55611 OTUB1

dbSNP Gene:55611 OTUB1

ENSEMBL:ENSG00000167770 OTUB1

HGNC:23077 OTUB1

KEGG Gene (Homo sapiens):55611 OTUB1

Monarch:55611 OTUB1

NCBI Gene:55611 OTUB1

OMIM:608337 OTUB1

UCSC:Q96FW1 OTUB1

Reference Transcript

RefSeq:NM_017670.2 OTUB1

Other Identifiers

0007100672

11717771_a_at

11717772_a_at

16726188

201245_3p_s_at

201245_s_at

201246_s_at

3334138

3334139

3334141

3334142

3334145

3334148

3334151

3334153

3334154

3334156

3334159

3334160

3334161

3334162

3334163

3334164

3334166

38710_at

55611

7940840

A_14_P129860

A_23_P24375

A_32_P58816

GE56373

GO:0002250

GO:0002376

GO:0003674

GO:0004843

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006464

GO:0006508

GO:0006950

GO:0006974

GO:0008150

GO:0008233

GO:0008234

GO:0016579

GO:0016787

GO:0019784

GO:0019899

GO:0031625

GO:0032182

GO:0034641

GO:0036459

GO:0043130

GO:0043226

GO:0051276

GO:0070062

GO:0071108

GO:0071347

GO:1901315

GO:2000780

Hs.108504.0.S1_3p_a_at

Hs.108504.0.S1_3p_s_at

ILMN_1723871

ILMN_1778017

ILMN_2354855

PH_hs_0026447

TC11002711.hg

g8923113_3p_s_at

Participant Of

hasMember

OTUB1,(OTUB2) [nucleoplasm]

Other forms of this molecule

OTUB1 [cytosol]

Inferred To

otub-1 [nucleoplasm] (Caenorhabditis elegans)

OTUB1 [nucleoplasm] (Bos taurus)

OTUB1 [nucleoplasm] (Canis familiaris)

OTUB1 [nucleoplasm] (Drosophila melanogaster)

OTUB1 [nucleoplasm] (Gallus gallus)

OTUB1 [nucleoplasm] (Plasmodium falciparum)

OTUB1 [nucleoplasm] (Sus scrofa)

otub1a [nucleoplasm] (Danio rerio)

Otub1 [nucleoplasm] (Mus musculus)

Otub1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_060140.2

OpenTargets

ENSG00000167770

HPA

ENSG00000167770-OTUB1

GeneCards

Q96FW1

Ensembl

ENSP00000402551, ENST00000538426, ENSG00000167770, ENST00000428192, ENSP00000444357

PRO

Q96FW1

PDB

2ZFY, 4LDT, 4DHZ, 4DDG, 3VON, 4DDI, 4I6L

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [cytosol] (R-HSA-8864210) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.74	5
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.632	5
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.632	8
UniProt:P43246 MSH2	3	MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243) MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 R406* [nucleoplasm] (R-HSA-5575594)	0.564	3
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2 [cytosol] (R-HSA-50847)	0.499	3

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