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BACE1 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-6783326
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9UJY5 GGA1
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
NAT8,8B acetylate BACE1 (Homo sapiens)
BACE1 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P56817 BACE1
Gene Names
BACE1, BACE, KIAA1149
Chain
signal peptide:1-21, propeptide:22-45, chain:46-501
Reference Genes
BioGPS Gene:23621 BACE1
COSMIC (genes):BACE1 BACE1
CTD Gene:23621 BACE1
dbSNP Gene:23621 BACE1
ENSEMBL:ENSG00000186318 BACE1
ENSEMBL_homo_sapiens_GENE:ENSG00000186318.18 BACE1
HGNC:933 BACE1
KEGG Gene (Homo sapiens):23621 BACE1
Monarch:23621 BACE1
NCBI Gene:23621 BACE1
OMIM:604252 BACE1
UCSC:P56817 BACE1
Reference Transcript
RefSeq:NM_138973.3 BACE1
RefSeq:NM_012104.4 BACE1
RefSeq:NM_138972.3 BACE1
RefSeq:NM_001207049.1 BACE1
RefSeq:NM_138971.3 BACE1
Other Identifiers
11716390_a_at
11716391_a_at
11749940_a_at
11753657_a_at
11753658_x_at
11754653_a_at
16744822
217904_PM_s_at
217904_s_at
222462_PM_s_at
222462_s_at
222463_PM_s_at
222463_s_at
224335_PM_s_at
224335_s_at
23621
3393256
3393258
3393259
3393260
3393261
3393262
3393263
3393264
3393265
3393267
3393268
3393270
3393273
3393276
3393277
3393279
3393280
3393281
3393282
3393284
3393295
3393296
3393297
3393298
44849_at
45790_at
7951910
A_33_P3240936
A_33_P3240941
GE58458
GO:0001540
GO:0003824
GO:0004175
GO:0004190
GO:0005515
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005771
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005802
GO:0005886
GO:0006508
GO:0006509
GO:0008021
GO:0008233
GO:0008798
GO:0009986
GO:0010008
GO:0010288
GO:0012501
GO:0016020
GO:0016485
GO:0016787
GO:0019899
GO:0023052
GO:0030424
GO:0030425
GO:0030659
GO:0031410
GO:0034205
GO:0042987
GO:0042995
GO:0043025
GO:0043226
GO:0043525
GO:0045121
GO:0050435
GO:0050804
GO:0050877
GO:0050966
GO:0051604
GO:0055037
GO:0060134
GO:0070931
GO:0071280
GO:0071287
GO:0098686
GO:0098793
GO:0099171
GO:0140096
GO:0140448
GO:1904646
GO:1990000
HMNXSV003025985
HMNXSV003046053
Hs.49349.0.S3_3p_a_at
ILMN_1797804
ILMN_2320349
PH_hs_0003439
TC11002335.hg
TC11003367.hg
TC11003368.hg
g13568406_3p_s_at
g6118538_3p_a_at
g6912265_3p_a_at
p2517
Participates
as an input of
NAT8,8B acetylate BACE1 (Homo sapiens)
Other forms of this molecule
7K-BACE1 [endoplasmic reticulum lumen]
BACE1(22-45) [Golgi-associated vesicle lumen]
7K-BACE1 [Golgi-associated vesicle lumen]
7K-BACE1(46-501) [Golgi-associated vesicle lumen]
BACE1(46-501) [Golgi-associated vesicle lumen]
BACE1(46-501) [plasma membrane]
BACE1 [endosome membrane]
Cross References
RefSeq
NP_620427.1
,
NP_620429.1
,
NP_001193978.1
,
NP_620428.1
,
NP_036236.1
ZINC - World Drugs
BACE1_HUMAN
Guide to Pharmacology - Targets
2330
OpenTargets
ENSG00000186318
ZINC - FDA approved
BACE1_HUMAN
ZINC - Substances
BACE1_HUMAN
ZINC - Biogenic
BACE1_HUMAN
ZINC target
P56817
PRO
P56817
PDB
4LXA
,
6WNY
,
4J17
,
3SKG
,
4BEK
,
3L5F
,
3RU1
,
7D36
,
5QDC
,
1XS7
,
2FDP
,
2QU3
,
4B00
,
4I0J
,
4WY1
,
3S2O
,
3INF
,
3OHH
,
1YM4
,
2Q11
,
2VNN
,
5QD8
,
3UDH
,
4PZW
,
5EZZ
,
7F1D
,
6NV7
,
6DHC
,
1TQF
,
2VJ6
,
4ACU
,
2VA7
,
5MXD
,
6UWP
,
4FS4
,
6NW3
,
4JPC
,
4J0Z
,
4GMI
,
6JSN
,
4B78
,
3R1G
,
5HDZ
,
3UQP
,
5CLM
,
4J1E
,
5QDA
,
2QMD
,
2VJ9
,
4LXM
,
4I10
,
5QCY
,
2ZJJ
,
5QD7
,
3U6A
,
3MSJ
,
3UDR
,
2P4J
,
4H3J
,
7DCZ
,
4IVT
,
5T1W
,
4R5N
,
4FGX
,
5QCW
,
5QD5
,
2WF0
,
4DH6
,
2NTR
,
2VA5
,
4DPF
,
5ENK
,
5QCT
,
3VF3
,
4AZY
,
4X2L
,
1M4H
,
4ZPE
,
3UDM
,
1UJK
,
6BFX
,
4TRZ
,
5I3X
,
5YGY
,
4H3G
,
6JSF
,
3LPJ
,
3OOZ
,
4R95
,
2IRZ
,
3EXO
,
2XFK
,
4XKX
,
4RRN
,
2OHN
,
4J1I
,
5QCV
,
6BFD
,
4KE0
,
3FKT
,
2OHQ
,
3UDP
,
2VIY
,
3HW1
,
4YBI
,
4K9H
,
4FRI
,
5MCQ
,
2ZHT
,
5HDV
,
3L5C
,
4JOO
,
4ZPG
,
4B72
,
4J0V
,
3IND
,
6DMI
,
1W50
,
6UWV
,
6JT3
,
4D88
,
5V0N
,
5F01
,
3RSX
,
4DV9
,
3INH
,
2PH6
,
5QD3
,
4EWO
,
4I1C
,
2QP8
,
4XXS
,
5HE7
,
3WB5
,
5QCR
,
3DV1
,
4LC7
,
2VKM
,
2VIE
,
3LNK
,
5HD0
,
3UQW
,
6UVP
,
5KR8
,
2G94
,
2ZJH
,
2HIZ
,
3S7L
,
7B1Q
,
4L7J
,
3TPP
,
4I0H
,
6C2I
,
4RCF
,
4TRW
,
3RTM
,
3N4L
,
4D8C
,
4B1C
,
4J1F
,
2ZE1
,
5MBW
,
3CKR
,
3BUG
,
2F3F
,
2QZK
,
3L59
,
6EJ2
,
2WF3
,
4DJV
,
7MYI
,
7N66
,
3IN4
,
2XFI
,
3CID
,
5QDD
,
5HU0
,
5QCO
,
4DJX
,
3H0B
,
3L5D
,
2VJ7
,
6NV9
,
3TPJ
,
3UDJ
,
2ZHR
,
4B05
,
5QCP
,
4I0D
,
4D83
,
4B1E
,
3IXJ
,
4I0F
,
4RCD
,
3UQR
,
7D5A
,
3L38
,
5QDB
,
2OHT
,
5I3V
,
3RVI
,
5QD1
,
4H1E
,
2Q15
,
4FM7
,
3K5F
,
4ZSQ
,
2ZJM
,
2OHL
,
4BFD
,
5HE4
,
3MSK
,
2P8H
,
4L7G
,
2OAH
,
4KE1
,
2OHR
,
4FRS
,
3QBH
,
5QD6
,
4PZX
,
7D2V
,
3IVH
,
4LXK
,
3VV6
,
4DPI
,
3CIB
,
6FGY
,
3RTN
,
3VEU
,
4ZSM
,
4FRJ
,
3LPK
,
4J0P
,
3KYR
,
3UDY
,
2HM1
,
3ZMG
,
4R8Y
,
3VG1
,
2VIZ
,
3OHF
,
2QU2
,
4WY6
,
5I3Y
,
6BFE
,
3VV8
,
4I11
,
4ACX
,
2ZHU
,
2WF1
,
3SKF
,
6E3Z
,
4J1C
,
3KN0
,
5TOL
,
3L5E
,
4JPE
,
3KMX
,
2QMF
,
3R2F
,
3INE
,
4FSE
,
5ENM
,
1XN2
,
3BRA
,
4H3I
,
3K5C
,
4IVS
,
4X7I
,
5HDX
,
5QD9
,
2ZJK
,
4J0Y
,
5QCZ
,
2VNM
,
5QCX
,
4RRO
,
4D89
,
4ZPF
,
4HZT
,
5QD4
,
2QK5
,
1W51
,
3BUH
,
5EZX
,
2QZL
,
6EJ3
,
4H3F
,
2PH8
,
5I3W
,
2OHP
,
4J1K
,
3RTH
,
2VA6
,
4R92
,
3UDQ
,
3DM6
,
4K8S
,
2ZJI
,
1PY1
,
7B1E
,
6JSG
,
1YM2
,
6PZ4
,
2VIJ
,
5UYU
,
1FKN
,
4J0T
,
3IGB
,
6UVV
,
2WF4
,
3L5B
,
3WB4
,
5HDU
,
4DI2
,
2B8L
,
4JP9
,
3LPI
,
6JT4
,
2OF0
,
5T1U
,
4R91
,
2IS0
,
4I0Z
,
4B77
,
4I12
,
4D85
,
2WJO
,
5HU1
,
2XFJ
,
2IQG
,
3DV5
,
3RSV
,
3KMY
,
3HVG
,
1XN3
,
6JSE
,
6EQM
,
2OHM
,
4J1H
,
4WTU
,
3NSH
,
5QCS
,
2OHU
,
3UQX
,
4FCO
,
2WF2
,
6BFW
,
5YGX
,
4RRS
,
3L58
,
3TPR
,
5IE1
,
3IXK
,
5MCO
,
3UDN
,
2ZJN
,
2ZHS
,
4RCE
,
4I0I
,
5QCU
,
3K5G
,
5QD2
,
4ZSR
,
2F3E
,
4TRY
,
4B70
,
2ZDZ
,
4EXG
,
7MYR
,
3CKP
,
3BUF
,
3L3A
,
4R93
,
4GID
,
3S7M
,
4DUS
,
2B8V
,
3PI5
,
3VV7
,
4B0Q
,
2P83
,
2OHK
,
4ZSP
,
7D2X
,
2OHS
,
3IVI
,
3CIC
,
3IN3
,
2QMG
,
3ZOV
,
4HA5
,
4FRK
,
5F00
,
4B1D
,
4DJU
,
5QCQ
,
3LHG
,
3UQU
,
4I0E
,
5DQC
,
7B1P
,
3QI1
,
5HE5
,
6OD6
,
2ZHV
,
5HTZ
,
4DJW
,
4I0G
,
1SGZ
,
2WEZ
,
3I25
,
5KQF
,
3TPL
,
4DJY
,
3UDK
,
2ZJL
,
4DVF
,
3MSL
,
4FM8
,
6UVY
,
4FSL
,
3DUY
,
1UJJ
,
3K5D
,
4N00
,
3UFL
,
4L7H
,
5QD0
,
7MYU
ZINC - Investigational
BACE1_HUMAN
ZINC - Metabolites
BACE1_HUMAN
HPA
ENSG00000186318-BACE1
GeneCards
P56817
Ensembl
ENSG00000186318
,
ENSP00000422461
,
ENST00000513780
,
ENSP00000424536
,
ENSP00000318585
,
ENST00000428381
,
ENST00000510630
,
ENSP00000402228
,
ENST00000392937
,
ENSP00000475405
,
ENST00000313005
,
ENST00000445823
,
ENSP00000403685
Pharos - Targets
P56817
ZINC - Predictions - Purchasable
BACE1_HUMAN
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.865
11
UniProt:Q9UJY5 GGA1
2
GGA1 [early endosome membrane]
(R-HSA-8854136)
GGA1 [endosome membrane]
(R-HSA-5692930)
0.668
4
UniProt:P49768 PSEN1
6
PSEN1(1-467) [plasma membrane]
(R-HSA-201606)
PSEN1(299-467) [azurophil granule membrane]
(R-HSA-6799234)
PSEN1(1-467) [azurophil granule membrane]
(R-HSA-6799235)
PSEN1(1-298) [azurophil granule membrane]
(R-HSA-6799209)
PSEN1(1-298) [plasma membrane]
(R-HSA-2534298)
PSEN1(299-467) [plasma membrane]
(R-HSA-2534245)
0.639
6
UniProt:P10997 IAPP
2
IAPP(1-89) [cytosol]
(R-HSA-186631)
IAPP(34-70) [extracellular region]
(R-HSA-420076)
0.558
2
UniProt:Q9Y287 ITM2B
1
ITM2B(244-266) [extracellular region]
(R-HSA-976878)
0.556
4
UniProt:Q9UJY4 GGA2
2
GGA2 [early endosome membrane]
(R-HSA-8854140)
GGA2 [endosome membrane]
(R-HSA-5692937)
0.544
2
UniProt:Q9NZ52 GGA3
3
GGA3 [endosome membrane]
(R-HSA-5692936)
GGA3 [recycling endosome membrane]
(R-HSA-8875655)
GGA3 [early endosome membrane]
(R-HSA-8854137)
0.544
2
UniProt:Q03721 KCNC4
1
KCNC4 [plasma membrane]
(R-HSA-977458)
0.524
3
UniProt:Q8BNX1
1
Clec4g [plasma membrane]
(R-MMU-1472852)
0.524
2
UniProt:Q9UNH7 SNX6
0.499
2
UniProt:O14672 ADAM10
6
ADAM10(215-824) [plasma membrane]
(R-HSA-179885)
ADAM10 [plasma membrane]
(R-HSA-157237)
ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956768)
p-ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956999)
ADAM10 [tertiary granule membrane]
(R-HSA-6800992)
ADAM10 [specific granule membrane]
(R-HSA-6799566)
0.454
3
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