Reactome | BACE1 [endoplasmic reticulum lumen]

BACE1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-6783326

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Beta-secretase 1 ecNumber3.4.23.46/ecNumber, BACE1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9Y287 ITM2B

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External Reference Information

External Reference

UniProt:P56817 BACE1

Gene Names

BACE1, BACE, KIAA1149

Chain

signal peptide:1-21, propeptide:22-45, chain:46-501

Reference Genes

COSMIC (genes):BACE1 BACE1

dbSNP Gene:23621 BACE1

ENSEMBL:ENSG00000186318 BACE1

Participates

as an input of

NAT8,8B acetylate BACE1 (Homo sapiens)

Other forms of this molecule

7K-BACE1 [endoplasmic reticulum lumen]

BACE1(22-45) [Golgi-associated vesicle lumen]

7K-BACE1 [Golgi-associated vesicle lumen]

7K-BACE1(46-501) [Golgi-associated vesicle lumen]

BACE1(46-501) [Golgi-associated vesicle lumen]

BACE1(46-501) [plasma membrane]

BACE1 [endosome membrane]

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.865	11
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.668	4
UniProt:P49768 PSEN1	6	PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.639	6
UniProt:P10997 IAPP	2	IAPP(34-70) [extracellular region] (R-HSA-420076) IAPP(1-89) [cytosol] (R-HSA-186631)	0.558	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.556	4
UniProt:Q9UJY4 GGA2	2	GGA2 [early endosome membrane] (R-HSA-8854140) GGA2 [endosome membrane] (R-HSA-5692937)	0.544	2
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [recycling endosome membrane] (R-HSA-8875655)	0.544	2
UniProt:Q03721 KCNC4	1	KCNC4 [plasma membrane] (R-HSA-977458)	0.524	3
UniProt:Q8BNX1	1	Clec4g [plasma membrane] (R-MMU-1472852)	0.524	2
UniProt:Q9UNH7 SNX6			0.499	2
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [specific granule membrane] (R-HSA-6799566) ADAM10 [tertiary granule membrane] (R-HSA-6800992)	0.454	3