Reactome: A Curated Pathway Database

APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region

Stable Identifier
R-HSA-6783332
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The Abeta peptides 42 and 40 (APP(672-713) and APP(673-711) respectively) are thought to be the main fibril-forming peptides implicated in neurodegenerative disorders. They translocate from the endosomal lumen to the extracellular region by an unknown mechanism (Qui et al. 2015, Baranello et al. 2015).

Literature References
Participants
Participant Of