LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-HSA-6783473
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasm
ReviewStatus
5/5
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LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)
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LCMT2 (TYW4) methoxycarbonylates OHyW-72 (7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine) at nucleotide 37 of tRNA(Phe), yielding OHyW (hydroxywybutosine) (Noma et al. 2010).
Literature References
PubMed ID Title Journal Year
20739293 Expanding role of the jumonji C domain as an RNA hydroxylase

Noma, A, Ishitani, R, Kato, M, Nagao, A, Nureki, O, Suzuki, T

J. Biol. Chem. 2010
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA methyltransferase activity of LCMT2 [cytoplasm]

Physical Entity
LCMT2 [cytoplasm] (Homo sapiens)
Activity
tRNA methyltransferase activity (GO:0008175)
Authored
May, B  (2015-06-15)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-15)
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