Reactome: A Curated Pathway Database

tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol

Stable Identifier
R-HSA-6783483
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The nuclear export receptor XPOT (Exportin-t) interacts with both tRNA (Li and Sprinzl 2006) and RAN:GTP and the complex is translocated from the nucleus to the cytosol through the nuclear pore (Arts et al. 1998, Kutay et al. 1998, Kuersten et al. 2002, reviewed in Leisegang et al. 2012). RAN:GTP-dependent interactions of XPOT with components of the nuclear pore may increase the efficiency of the transport cycle (Kuersten et al. 2002).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
nucleocytoplasmic transporter activity of Nuclear Pore Complex (NPC) [nuclear envelope] Nuclear Pore Complex (NPC) [nuclear envelope] nucleocytoplasmic transporter activity (0005487)